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    OSGIN2 oxidative stress induced growth inhibitor family member 2 [ Homo sapiens (human) ]

    Gene ID: 734, updated on 5-Mar-2024

    Summary

    Official Symbol
    OSGIN2provided by HGNC
    Official Full Name
    oxidative stress induced growth inhibitor family member 2provided by HGNC
    Primary source
    HGNC:HGNC:1355
    See related
    Ensembl:ENSG00000164823 MIM:604598; AllianceGenome:HGNC:1355
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    hT41; C8orf1
    Summary
    Predicted to enable growth factor activity. Predicted to be involved in negative regulation of cell growth. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in fat (RPKM 10.6), brain (RPKM 9.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    8q21.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (89901868..89927888)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (91025051..91051069)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (90914096..90940116)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27606 Neighboring gene cytochrome c oxidase subunit 6B1 pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27607 Neighboring gene MPRA-validated peak7104 silencer Neighboring gene Sharpr-MPRA regulatory region 7187 Neighboring gene uncharacterized LOC124901974 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:90912677-90913442 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:90913443-90914208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19347 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:90914502-90914800 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19348 Neighboring gene RNA, U6 small nuclear 925, pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:90959982-90961181 Neighboring gene nibrin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27608 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:90996459-90997255 Neighboring gene Sharpr-MPRA regulatory region 13813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27609 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27611 Neighboring gene 2,4-dienoyl-CoA reductase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell growth IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    oxidative stress-induced growth inhibitor 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126111.3NP_001119583.1  oxidative stress-induced growth inhibitor 2 isoform 1

      See identical proteins and their annotated locations for NP_001119583.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate 5'UTR that includes a translation start site that is upstream and in-frame with that used for variant 2. The resulting protein (isoform 1) is longer and has a distinct N-terminus compared to isoform 2.
      Source sequence(s)
      AF061326, BC031054, BM764021, BU739360
      Consensus CDS
      CCDS47888.1
      UniProtKB/Swiss-Prot
      Q9Y236
      Related
      ENSP00000396445.2, ENST00000451899.7
      Conserved Domains (1) summary
      cl21454
      Location:217363
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. NM_004337.2NP_004328.1  oxidative stress-induced growth inhibitor 2 isoform 2

      See identical proteins and their annotated locations for NP_004328.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5'UTR resulting in translation initiation from an internal AUG site compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
      Source sequence(s)
      AF061326, BC031054, BU688773
      Consensus CDS
      CCDS6248.1
      UniProtKB/Swiss-Prot
      Q9Y236
      Related
      ENSP00000297438.2, ENST00000297438.6
      Conserved Domains (1) summary
      cl21454
      Location:173319
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      89901868..89927888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011517287.4XP_011515589.1  oxidative stress-induced growth inhibitor 2 isoform X1

      See identical proteins and their annotated locations for XP_011515589.1

      UniProtKB/Swiss-Prot
      Q9Y236
      Conserved Domains (1) summary
      cl21454
      Location:173319
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. XM_011517288.4XP_011515590.1  oxidative stress-induced growth inhibitor 2 isoform X2

      Conserved Domains (1) summary
      cl21454
      Location:40186
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      91025051..91051069
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361178.1XP_054217153.1  oxidative stress-induced growth inhibitor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9Y236
    2. XM_054361179.1XP_054217154.1  oxidative stress-induced growth inhibitor 2 isoform X2