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    Adipor1 adiponectin receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 72674, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Adipor1provided by MGI
    Official Full Name
    adiponectin receptor 1provided by MGI
    Primary source
    MGI:MGI:1919924
    See related
    Ensembl:ENSMUSG00000026457 AllianceGenome:MGI:1919924
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Paqr1; ACDCR1; CGI-45; 2810031L11Rik
    Summary
    This gene encodes a receptor for the fat-derived hormone adiponectin. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. Homozygous knockout mice for this gene exhibit elevated plasma glucose and insulin levels as well as impaired glucose tolerance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 87.2), colon adult (RPKM 63.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adipor1 in Genome Data Viewer
    Location:
    1 E4; 1 58.22 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (134343116..134361089)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (134415378..134433351)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02326 Neighboring gene MGAT4 family, member F Neighboring gene STARR-seq mESC enhancer starr_02328 Neighboring gene cytochrome b5 reductase 1 Neighboring gene STARR-seq mESC enhancer starr_02333 Neighboring gene kelch-like 12 Neighboring gene STARR-positive B cell enhancer ABC_E3304 Neighboring gene RAB interacting factor Neighboring gene predicted gene, 25612

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Restoring retinal polyunsaturated fatty acid balance and retina function by targeting ceramide in AdipoR1-deficient mice. Lewandowski D, et al. J Biol Chem, 2024 May. PMID 38636661, Free PMC Article
    2. Weight Gain Alters Adiponectin Receptor 1 Expression on Adipose Tissue-Resident Helios+ Regulatory T Cells. Ramos-Ramírez P, et al. Scand J Immunol, 2016 Apr. PMID 26900653
    3. Adiponectin receptor 1 conserves docosahexaenoic acid and promotes photoreceptor cell survival. Rice DS, et al. Nat Commun, 2015 Mar 4. PMID 25736573, Free PMC Article
    4. Effects of obesity on severity of colitis and cytokine expression in mouse mesenteric fat. Potential role of adiponectin receptor 1. Sideri A, et al. Am J Physiol Gastrointest Liver Physiol, 2015 Apr 1. PMID 25591865, Free PMC Article
    5. Suppression of adiponectin receptor 1 promotes memory dysfunction and Alzheimer's disease-like pathologies. Kim MW, et al. Sci Rep, 2017 Sep 29. PMID 28963462, Free PMC Article

    See all (135) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Decreased AdipoR1 signaling and its implications for obesity-induced male infertility.
      Title: Decreased AdipoR1 signaling and its implications for obesity-induced male infertility.
    2. Adiponectin receptor 1-mediated stimulation of Cav3.2 channels in trigeminal ganglion neurons induces nociceptive behaviors in mice.
      Title: Adiponectin receptor 1-mediated stimulation of Cav3.2 channels in trigeminal ganglion neurons induces nociceptive behaviors in mice.
    3. Targeting Adiponectin Receptor 1 Phosphorylation Against Ischemic Heart Failure.
      Title: Targeting Adiponectin Receptor 1 Phosphorylation Against Ischemic Heart Failure.
    4. Estradiol overcomes adiponectin-resistance in diabetic mice by regulating skeletal muscle adiponectin receptor 1 expression.
      Title: Estradiol overcomes adiponectin-resistance in diabetic mice by regulating skeletal muscle adiponectin receptor 1 expression.
    5. Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision.
      Title: Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision.
    6. Genetic Interaction between Mfrp and Adipor1 Mutations Affect Retinal Disease Phenotypes.
      Title: Genetic Interaction between Mfrp and Adipor1 Mutations Affect Retinal Disease Phenotypes.
    7. Modulation of depression-related behaviors by adiponectin AdipoR1 receptors in 5-HT neurons.
      Title: Modulation of depression-related behaviors by adiponectin AdipoR1 receptors in 5-HT neurons.
    8. Adiponectin inhibits Dgalinduced cardiomyocyte senescence via AdipoR1/APPL1.
      Title: Adiponectin inhibits D‑gal‑induced cardiomyocyte senescence via AdipoR1/APPL1.
    9. ADIPOR1 deficiency-induced suppression of retinal ELOVL2 and docosahexaenoic acid levels during photoreceptor degeneration and visual loss.
      Title: ADIPOR1 deficiency-induced suppression of retinal ELOVL2 and docosahexaenoic acid levels during photoreceptor degeneration and visual loss.
    10. Adiponectin exacerbates influenza infection in elderly individuals via IL-18.
      Title: Adiponectin exacerbates influenza infection in elderly individuals via IL-18.
    Submit: New GeneRIF Correction See all GeneRIFs (84)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables adipokinetic hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adipokinetic hormone receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables adiponectin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables adiponectin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adiponectin-activated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within adiponectin-activated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adiponectin-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in adiponectin-activated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hormone-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hormone-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in leptin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in leptin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of epithelial cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of epithelial to mesenchymal transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of non-canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    adiponectin receptor protein 1
    Names
    progestin and adipoQ receptor family member 1
    progestin and adipoQ receptor family member I

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001306069.1 → NP_001292998.1  adiponectin receptor protein 1

      See identical proteins and their annotated locations for NP_001292998.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC131592, AK143680, AW047193, AY424290, CK623806
      Consensus CDS
      CCDS15309.1
      UniProtKB/Swiss-Prot
      Q91VH1, Q9CZA0
      UniProtKB/TrEMBL
      Q3TI02, Q3UPA4, Q53YY4
      Related
      ENSMUSP00000107856.2, ENSMUST00000112237.2
      Conserved Domains (1) summary
      pfam03006
      Location:129 → 352
      HlyIII; Haemolysin-III related

    2. NM_028320.4 → NP_082596.2  adiponectin receptor protein 1

      See identical proteins and their annotated locations for NP_082596.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC131592, AK143680, AW047193, AY424290, CA945374
      Consensus CDS
      CCDS15309.1
      UniProtKB/Swiss-Prot
      Q91VH1, Q9CZA0
      UniProtKB/TrEMBL
      Q3TI02, Q3UPA4, Q53YY4
      Related
      ENSMUSP00000027727.9, ENSMUST00000027727.15
      Conserved Domains (1) summary
      pfam03006
      Location:129 → 352
      HlyIII; Haemolysin-III related

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      134343116..134361089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91VH1.1 GenPept UniProtKB/Swiss-Prot:Q91VH1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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