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ADIPOR1 adiponectin receptor 1 [ Homo sapiens (human) ]

Gene ID: 51094, updated on 12-Aug-2018
Official Symbol
ADIPOR1provided by HGNC
Official Full Name
adiponectin receptor 1provided by HGNC
Primary source
HGNC:HGNC:24040
See related
Ensembl:ENSG00000159346 MIM:607945; Vega:OTTHUMG00000041391
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI45; PAQR1; ACDCR1; CGI-45; TESBP1A
Summary
This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014]
Expression
Ubiquitous expression in bone marrow (RPKM 58.7), placenta (RPKM 45.4) and 25 other tissues See more
Orthologs
See ADIPOR1 in Genome Data Viewer
Location:
1q32.1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (202940825..202958572, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (202909960..202927700, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RAB interacting factor Neighboring gene kelch like family member 12 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 59 Neighboring gene cytochrome b5 reductase 1 Neighboring gene alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein LOC641515 homolog Neighboring gene ribosomal protein S20 pseudogene 8

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • AMP-activated Protein Kinase (AMPK) Signaling, organism-specific biosystem (from WikiPathways)
    AMP-activated Protein Kinase (AMPK) Signaling, organism-specific biosystemAMPK signaling pathway, a fuel sensor and regulator, promotes ATP-producing and inhibits ATP-consuming pathways in various tissues. AMPK is a heterotrimer composed of alpha-catalytic and beta and gam...
  • AMPK inhibits chREBP transcriptional activation activity, organism-specific biosystem (from REACTOME)
    AMPK inhibits chREBP transcriptional activation activity, organism-specific biosystemAMP-activated protein kinase (AMPK) is a sensor of cellular energy levels. A high cellular ratio of AMP:ATP triggers the phosphorylation and activation of AMPK. Activated AMPK in turn phosphorylates ...
  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
    Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
    Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Integration of energy metabolism, organism-specific biosystem (from REACTOME)
    Integration of energy metabolism, organism-specific biosystemMany hormones that affect individual physiological processes including the regulation of appetite, absorption, transport, and oxidation of foodstuffs influence energy metabolism pathways. While insul...
  • Longevity regulating pathway, organism-specific biosystem (from KEGG)
    Longevity regulating pathway, organism-specific biosystemRegulation of longevity depends on genetic and environmental factors. Caloric restriction (CR), that is limiting food intake, is recognized in mammals as the best characterized and most reproducible ...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ25385, FLJ42464

Gene Ontology Provided by GOA

Function Evidence Code Pubs
adipokinetic hormone receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
adiponectin binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
adiponectin-activated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adiponectin-activated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid oxidation IDA
Inferred from Direct Assay
more info
PubMed 
glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
hormone-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
leptin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of JAK-STAT cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of JAK-STAT cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of fatty acid biosynthetic process TAS
Traceable Author Statement
more info
 
regulation of glucose metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intrinsic component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
adiponectin receptor protein 1
Names
progestin and adipoQ receptor family member 1
progestin and adipoQ receptor family member I

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052860.1 RefSeqGene

    Range
    5001..22748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001290553.1NP_001277482.1  adiponectin receptor protein 1

    See identical proteins and their annotated locations for NP_001277482.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as R1T2) has an alternate 5' UTR exon, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AI251444, BC010743, DA523648
    Consensus CDS
    CCDS1430.1
    UniProtKB/Swiss-Prot
    Q96A54
    Conserved Domains (1) summary
    pfam03006
    Location:129352
    HlyIII; Haemolysin-III related
  2. NM_001290557.1NP_001277486.1  adiponectin receptor protein 1

    See identical proteins and their annotated locations for NP_001277486.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as R1T3) has an additional internal exon in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AC096632, AI251444, BC010743, BI597715
    Consensus CDS
    CCDS1430.1
    UniProtKB/Swiss-Prot
    Q96A54
    Conserved Domains (1) summary
    pfam03006
    Location:129352
    HlyIII; Haemolysin-III related
  3. NM_001290629.1NP_001277558.1  adiponectin receptor protein 1

    See identical proteins and their annotated locations for NP_001277558.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as R1T4) has an alternate 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AI251444, BC010743, BI597715, BX461217
    Consensus CDS
    CCDS1430.1
    UniProtKB/Swiss-Prot
    Q96A54
    Conserved Domains (1) summary
    pfam03006
    Location:129352
    HlyIII; Haemolysin-III related
  4. NM_015999.5NP_057083.2  adiponectin receptor protein 1

    See identical proteins and their annotated locations for NP_057083.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as R1T1) is a predominant transcript. All variants encode the same protein.
    Source sequence(s)
    AC096632, AI251444, BC010743
    Consensus CDS
    CCDS1430.1
    UniProtKB/Swiss-Prot
    Q96A54
    Related
    ENSP00000341785.5, OTTHUMP00000038805, ENST00000340990.9, OTTHUMT00000099160
    Conserved Domains (1) summary
    pfam03006
    Location:129352
    HlyIII; Haemolysin-III related

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    202940825..202958572 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447427.1XP_024303195.1  adiponectin receptor protein 1 isoform X1

    Conserved Domains (1) summary
    pfam03006
    Location:11197
    HlyIII; Haemolysin-III related
  2. XM_017001407.1XP_016856896.1  adiponectin receptor protein 1 isoform X1

    Conserved Domains (1) summary
    pfam03006
    Location:11197
    HlyIII; Haemolysin-III related

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_046083.1: Suppressed sequence

    Description
    NR_046083.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
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