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ADIPOR1 adiponectin receptor 1 [ Homo sapiens (human) ]

Gene ID: 51094, updated on 8-Jul-2021

Summary

Official Symbol
ADIPOR1provided by HGNC
Official Full Name
adiponectin receptor 1provided by HGNC
Primary source
HGNC:HGNC:24040
See related
Ensembl:ENSG00000159346 MIM:607945
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI45; PAQR1; ACDCR1; CGI-45; TESBP1A
Summary
This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014]
Expression
Ubiquitous expression in bone marrow (RPKM 58.7), placenta (RPKM 45.4) and 25 other tissues See more
Orthologs
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Genomic context

See ADIPOR1 in Genome Data Viewer
Location:
1q32.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (202940825..202958572, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (202909953..202927700, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RAB interacting factor Neighboring gene kelch like family member 12 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 59 Neighboring gene Sharpr-MPRA regulatory region 11793 Neighboring gene cytochrome b5 reductase 1 Neighboring gene MGAT4 family member F, pseudogene Neighboring gene ribosomal protein S20 pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25385, FLJ42464

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables adipokinetic hormone receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables adiponectin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in adiponectin-activated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adiponectin-activated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fatty acid oxidation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in hormone-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in leptin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of receptor signaling pathway via JAK-STAT IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of glucose metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intrinsic component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
adiponectin receptor protein 1
Names
progestin and adipoQ receptor family member 1
progestin and adipoQ receptor family member I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052860.1 RefSeqGene

    Range
    5001..22748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001290553.2NP_001277482.1  adiponectin receptor protein 1

    See identical proteins and their annotated locations for NP_001277482.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as R1T2) has an alternate 5' UTR exon, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AI251444, BC010743, DA523648
    Consensus CDS
    CCDS1430.1
    UniProtKB/Swiss-Prot
    Q96A54
    Conserved Domains (1) summary
    pfam03006
    Location:129352
    HlyIII; Haemolysin-III related
  2. NM_001290557.1NP_001277486.1  adiponectin receptor protein 1

    See identical proteins and their annotated locations for NP_001277486.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as R1T3) has an additional internal exon in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AC096632, AI251444, BC010743, BI597715
    Consensus CDS
    CCDS1430.1
    UniProtKB/Swiss-Prot
    Q96A54
    Conserved Domains (1) summary
    pfam03006
    Location:129352
    HlyIII; Haemolysin-III related
  3. NM_001290629.1NP_001277558.1  adiponectin receptor protein 1

    See identical proteins and their annotated locations for NP_001277558.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as R1T4) has an alternate 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AI251444, BC010743, BI597715, BX461217
    Consensus CDS
    CCDS1430.1
    UniProtKB/Swiss-Prot
    Q96A54
    Conserved Domains (1) summary
    pfam03006
    Location:129352
    HlyIII; Haemolysin-III related
  4. NM_015999.6NP_057083.2  adiponectin receptor protein 1

    See identical proteins and their annotated locations for NP_057083.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as R1T1) is a predominant transcript. All variants encode the same protein.
    Source sequence(s)
    AC096632, AI251444, BC010743
    Consensus CDS
    CCDS1430.1
    UniProtKB/Swiss-Prot
    Q96A54
    Related
    ENSP00000341785.5, ENST00000340990.10
    Conserved Domains (1) summary
    pfam03006
    Location:129352
    HlyIII; Haemolysin-III related

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    202940825..202958572 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447427.1XP_024303195.1  adiponectin receptor protein 1 isoform X1

    Conserved Domains (1) summary
    pfam03006
    Location:11197
    HlyIII; Haemolysin-III related
  2. XM_017001407.1XP_016856896.1  adiponectin receptor protein 1 isoform X1

    Conserved Domains (1) summary
    pfam03006
    Location:11197
    HlyIII; Haemolysin-III related

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_046083.1: Suppressed sequence

    Description
    NR_046083.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
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