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Adipor1 adiponectin receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 72674, updated on 26-Jun-2024

Summary

Official Symbol
Adipor1provided by MGI
Official Full Name
adiponectin receptor 1provided by MGI
Primary source
MGI:MGI:1919924
See related
Ensembl:ENSMUSG00000026457 AllianceGenome:MGI:1919924
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Paqr1; ACDCR1; CGI-45; 2810031L11Rik
Summary
This gene encodes a receptor for the fat-derived hormone adiponectin. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. Homozygous knockout mice for this gene exhibit elevated plasma glucose and insulin levels as well as impaired glucose tolerance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression
Ubiquitous expression in adrenal adult (RPKM 87.2), colon adult (RPKM 63.6) and 28 other tissues See more
Orthologs
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Genomic context

See Adipor1 in Genome Data Viewer
Location:
1 E4; 1 58.22 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (134343116..134361089)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (134415378..134433351)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02326 Neighboring gene MGAT4 family, member F Neighboring gene STARR-seq mESC enhancer starr_02328 Neighboring gene cytochrome b5 reductase 1 Neighboring gene STARR-seq mESC enhancer starr_02333 Neighboring gene kelch-like 12 Neighboring gene STARR-positive B cell enhancer ABC_E3304 Neighboring gene RAB interacting factor Neighboring gene predicted gene, 25612

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables adipokinetic hormone receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables adiponectin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables adiponectin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in adiponectin-activated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within adiponectin-activated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adiponectin-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adiponectin-activated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid oxidation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hormone-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in hormone-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in leptin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
adiponectin receptor protein 1
Names
progestin and adipoQ receptor family member 1
progestin and adipoQ receptor family member I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306069.1NP_001292998.1  adiponectin receptor protein 1

    See identical proteins and their annotated locations for NP_001292998.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC131592, AK143680, AW047193, AY424290, CK623806
    Consensus CDS
    CCDS15309.1
    UniProtKB/Swiss-Prot
    Q91VH1, Q9CZA0
    UniProtKB/TrEMBL
    Q3TI02, Q3UPA4, Q53YY4
    Related
    ENSMUSP00000107856.2, ENSMUST00000112237.2
    Conserved Domains (1) summary
    pfam03006
    Location:129352
    HlyIII; Haemolysin-III related
  2. NM_028320.4NP_082596.2  adiponectin receptor protein 1

    See identical proteins and their annotated locations for NP_082596.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC131592, AK143680, AW047193, AY424290, CA945374
    Consensus CDS
    CCDS15309.1
    UniProtKB/Swiss-Prot
    Q91VH1, Q9CZA0
    UniProtKB/TrEMBL
    Q3TI02, Q3UPA4, Q53YY4
    Related
    ENSMUSP00000027727.9, ENSMUST00000027727.15
    Conserved Domains (1) summary
    pfam03006
    Location:129352
    HlyIII; Haemolysin-III related

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    134343116..134361089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)