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    Pan3 PAN3 poly(A) specific ribonuclease subunit [ Mus musculus (house mouse) ]

    Gene ID: 72587, updated on 22-Aug-2021

    Summary

    Official Symbol
    Pan3provided by MGI
    Official Full Name
    PAN3 poly(A) specific ribonuclease subunitprovided by MGI
    Primary source
    MGI:MGI:1919837
    See related
    Ensembl:ENSMUSG00000029647
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AU014670; 2700050F09Rik; A430027N15Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 13.1), bladder adult (RPKM 8.2) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pan3 in Genome Data Viewer
    Location:
    5; 5 G3
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (147363018..147485311)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (147426208..147548501)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (148242156..148360077)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene DNA segment, Chr 5, ERATO Doi 605, expressed Neighboring gene predicted gene, 29793 Neighboring gene FMS-like tyrosine kinase 1 Neighboring gene predicted gene, 35383 Neighboring gene predicted gene, 35541

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC99847, MGC102350

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to poly(A)-specific ribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of PAN complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of PAN complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    PAN2-PAN3 deadenylation complex subunit Pan3
    Names
    PAB-dependent poly(A)-specific ribonuclease subunit 3
    PAB1P-dependent poly(A)-specific ribonuclease
    PAN3 polyA specific ribonuclease subunit homolog
    Pabp-dependent poly(A) nuclease 3
    Pabp1-dependent poly A-specific ribonuclease subunit Pan3
    poly(A)-nuclease deadenylation complex subunit 3
    NP_001346362.1
    NP_082567.3
    XP_006504931.1
    XP_006504932.1
    XP_006504933.1
    XP_006504934.1
    XP_006504935.1
    XP_006504936.1
    XP_006504940.1
    XP_006504941.1
    XP_017176602.1
    XP_030110691.1
    XP_036021422.1
    XP_036021423.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359433.1NP_001346362.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate internal exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC131730, AC134441, BC082547
      Conserved Domains (2) summary
      pfam18101
      Location:430567
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:181349
      PKc_like; Protein Kinases, catalytic domain
    2. NM_028291.5NP_082567.3  PAN2-PAN3 deadenylation complex subunit Pan3 isoform 1

      See identical proteins and their annotated locations for NP_082567.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC131730, AC134441
      Consensus CDS
      CCDS39401.2
      UniProtKB/Swiss-Prot
      Q640Q5
      Related
      ENSMUSP00000031651.9, ENSMUST00000031651.15
      Conserved Domains (2) summary
      pfam00642
      Location:5574
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      cl21453
      Location:439607
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      147363018..147485311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504872.4XP_006504935.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X5

      Conserved Domains (3) summary
      pfam00642
      Location:5574
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam18101
      Location:742852
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:493661
      PKc_like; Protein Kinases, catalytic domain
    2. XM_006504870.5XP_006504933.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X3

      UniProtKB/TrEMBL
      H3BKF3
      Related
      ENSMUSP00000135367.2, ENSMUST00000176600.8
      Conserved Domains (3) summary
      pfam00642
      Location:5574
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam18101
      Location:742879
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:493661
      PKc_like; Protein Kinases, catalytic domain
    3. XM_006504868.4XP_006504931.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X1

      Conserved Domains (3) summary
      pfam00642
      Location:5574
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam18101
      Location:742879
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:493661
      PKc_like; Protein Kinases, catalytic domain
    4. XM_017321113.2XP_017176602.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X6

      Conserved Domains (3) summary
      pfam00642
      Location:5574
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam18101
      Location:703840
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:571694
      PKc_like; Protein Kinases, catalytic domain
    5. XM_006504869.4XP_006504932.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X2

      Conserved Domains (3) summary
      pfam00642
      Location:5574
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam18101
      Location:741878
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:492660
      PKc_like; Protein Kinases, catalytic domain
    6. XM_036165529.1XP_036021422.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X7

      Conserved Domains (3) summary
      pfam00642
      Location:5574
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam18101
      Location:649786
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:517640
      PKc_like; Protein Kinases, catalytic domain
    7. XM_036165530.1XP_036021423.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X9

      Conserved Domains (2) summary
      pfam18101
      Location:430567
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:181349
      PKc_like; Protein Kinases, catalytic domain
    8. XM_006504878.4XP_006504941.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X11

      Conserved Domains (2) summary
      pfam18101
      Location:408545
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:159327
      PKc_like; Protein Kinases, catalytic domain
    9. XM_006504873.4XP_006504936.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X8

      Conserved Domains (3) summary
      pfam00642
      Location:5574
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam18101
      Location:556693
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:307475
      PKc_like; Protein Kinases, catalytic domain
    10. XM_006504871.4XP_006504934.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X4

      Conserved Domains (3) summary
      pfam00642
      Location:5574
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam18101
      Location:718855
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:469637
      PKc_like; Protein Kinases, catalytic domain
    11. XM_006504877.4XP_006504940.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X10

      Related
      ENSMUSP00000135729.2, ENSMUST00000175807.8
      Conserved Domains (2) summary
      pfam18101
      Location:411548
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:162330
      PKc_like; Protein Kinases, catalytic domain
    12. XM_030254831.2XP_030110691.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X9

      Conserved Domains (2) summary
      pfam18101
      Location:430567
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:181349
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_004942572.1 RNA Sequence

    2. XR_004942573.1 RNA Sequence

    3. XR_004942570.1 RNA Sequence

    4. XR_004942571.1 RNA Sequence

    5. XR_004942574.1 RNA Sequence

    6. XR_004942575.1 RNA Sequence

      Related
      ENSMUST00000176596.8
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