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    Pan3 PAN3 poly(A) specific ribonuclease subunit [ Mus musculus (house mouse) ]

    Gene ID: 72587, updated on 11-Apr-2024

    Summary

    Official Symbol
    Pan3provided by MGI
    Official Full Name
    PAN3 poly(A) specific ribonuclease subunitprovided by MGI
    Primary source
    MGI:MGI:1919837
    See related
    Ensembl:ENSMUSG00000029647 AllianceGenome:MGI:1919837
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2700050F09Rik; A430027N15Rik
    Summary
    Predicted to enable poly(A) binding activity. Predicted to contribute to poly(A)-specific ribonuclease activity. Acts upstream of or within deadenylation-dependent decapping of nuclear-transcribed mRNA; positive regulation of cytoplasmic mRNA processing body assembly; and protein targeting. Located in P-body. Orthologous to human PAN3 (poly(A) specific ribonuclease subunit PAN3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 13.1), bladder adult (RPKM 8.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pan3 in Genome Data Viewer
    Location:
    5 G3; 5 86.93 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (147363018..147485310)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (147426208..147548501)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14874 Neighboring gene STARR-seq mESC enhancer starr_14875 Neighboring gene STARR-positive B cell enhancer ABC_E8093 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:148238101-148238295 Neighboring gene DNA segment, Chr 5, ERATO Doi 605, expressed Neighboring gene predicted gene, 29793 Neighboring gene STARR-positive B cell enhancer ABC_E2773 Neighboring gene FMS-like tyrosine kinase 1 Neighboring gene predicted gene, 35383 Neighboring gene STARR-seq mESC enhancer starr_14879 Neighboring gene predicted gene, 35541

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC99847, MGC102350

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to poly(A)-specific ribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of PAN complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of PAN complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    PAN2-PAN3 deadenylation complex subunit Pan3
    Names
    PAB-dependent poly(A)-specific ribonuclease subunit 3
    PAB1P-dependent poly(A)-specific ribonuclease
    PAN3 polyA specific ribonuclease subunit homolog
    Pabp-dependent poly(A) nuclease 3
    Pabp1-dependent poly A-specific ribonuclease subunit Pan3
    poly(A)-nuclease deadenylation complex subunit 3
    NP_001346362.1
    NP_001406711.1
    NP_001406712.1
    NP_001406713.1
    NP_001406714.1
    NP_001406715.1
    NP_001406716.1
    NP_082567.3
    XP_006504932.1
    XP_006504934.1
    XP_006504935.1
    XP_006504940.1
    XP_006504941.1
    XP_017176602.1
    XP_030110691.1
    XP_036021422.1
    XP_036021423.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359433.2NP_001346362.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC131730, AC134441
      UniProtKB/TrEMBL
      H3BJH6
      Conserved Domains (2) summary
      pfam18101
      Location:430567
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:181349
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001419782.1NP_001406711.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC131730, AC134441
    3. NM_001419783.1NP_001406712.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC131730, AC134441
      UniProtKB/Swiss-Prot
      H3BKF3, Q3U5F2, Q640Q5, Q8CE75, Q9CZM6
    4. NM_001419784.1NP_001406713.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC131730, AC134441
    5. NM_001419785.1NP_001406714.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC131730, AC134441
    6. NM_001419786.1NP_001406715.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC131730, AC134441
    7. NM_001419787.1NP_001406716.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC131730, AC134441
    8. NM_028291.6NP_082567.3  PAN2-PAN3 deadenylation complex subunit Pan3 isoform 1

      See identical proteins and their annotated locations for NP_082567.3

      Status: VALIDATED

      Source sequence(s)
      AC131730, AC134441
      Consensus CDS
      CCDS39401.2
      UniProtKB/TrEMBL
      H3BJH6
      Related
      ENSMUSP00000031651.9, ENSMUST00000031651.15
      Conserved Domains (2) summary
      pfam00642
      Location:5574
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      cl21453
      Location:439607
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      147363018..147485310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504872.4XP_006504935.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X5

      Conserved Domains (3) summary
      pfam00642
      Location:5574
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam18101
      Location:742852
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:493661
      PKc_like; Protein Kinases, catalytic domain
    2. XM_017321113.2XP_017176602.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X6

      Conserved Domains (3) summary
      pfam00642
      Location:5574
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam18101
      Location:703840
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:571694
      PKc_like; Protein Kinases, catalytic domain
    3. XM_006504869.4XP_006504932.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X2

      Conserved Domains (3) summary
      pfam00642
      Location:5574
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam18101
      Location:741878
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:492660
      PKc_like; Protein Kinases, catalytic domain
    4. XM_036165529.1XP_036021422.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X7

      UniProtKB/TrEMBL
      H3BJH6
      Conserved Domains (3) summary
      pfam00642
      Location:5574
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam18101
      Location:649786
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:517640
      PKc_like; Protein Kinases, catalytic domain
    5. XM_036165530.1XP_036021423.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X9

      UniProtKB/TrEMBL
      H3BJH6
      Conserved Domains (2) summary
      pfam18101
      Location:430567
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:181349
      PKc_like; Protein Kinases, catalytic domain
    6. XM_006504878.4XP_006504941.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X11

      UniProtKB/TrEMBL
      H3BLB9
      Conserved Domains (2) summary
      pfam18101
      Location:408545
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:159327
      PKc_like; Protein Kinases, catalytic domain
    7. XM_006504871.4XP_006504934.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X4

      Conserved Domains (3) summary
      pfam00642
      Location:5574
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam18101
      Location:718855
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:469637
      PKc_like; Protein Kinases, catalytic domain
    8. XM_006504877.4XP_006504940.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X10

      UniProtKB/TrEMBL
      H3BLB9
      Related
      ENSMUSP00000135729.2, ENSMUST00000175807.8
      Conserved Domains (2) summary
      pfam18101
      Location:411548
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:162330
      PKc_like; Protein Kinases, catalytic domain
    9. XM_030254831.2XP_030110691.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X9

      UniProtKB/TrEMBL
      H3BJH6
      Conserved Domains (2) summary
      pfam18101
      Location:430567
      Pan3_PK; Pan3 Pseudokinase domain
      cl21453
      Location:181349
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_004942572.1 RNA Sequence

    2. XR_004942573.1 RNA Sequence

    3. XR_004942570.1 RNA Sequence

    4. XR_004942571.1 RNA Sequence

    5. XR_004942574.1 RNA Sequence

    6. XR_004942575.1 RNA Sequence

      Related
      ENSMUST00000176596.8