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PAN3 poly(A) specific ribonuclease subunit PAN3 [ Homo sapiens (human) ]

Gene ID: 255967, updated on 1-Jun-2020

Summary

Official Symbol
PAN3provided by HGNC
Official Full Name
poly(A) specific ribonuclease subunit PAN3provided by HGNC
Primary source
HGNC:HGNC:29991
See related
Ensembl:ENSG00000152520 MIM:617448
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in bone marrow (RPKM 8.7), spleen (RPKM 8.4) and 25 other tissues See more
Orthologs

Genomic context

See PAN3 in Genome Data Viewer
Location:
13q12.2
Exon count:
25
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (28135021..28295335)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (28710997..28869475)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene fms related receptor tyrosine kinase 3 Neighboring gene katanin regulatory subunit B1 like 1 pseudogene 1 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 8 Neighboring gene Sharpr-MPRA regulatory region 11800 Neighboring gene Sharpr-MPRA regulatory region 9463 Neighboring gene PAN3 antisense RNA 1 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 3 Neighboring gene RNA, U6 small nuclear 82, pseudogene Neighboring gene fms related receptor tyrosine kinase 1 Neighboring gene uncharacterized LOC105370135

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to poly(A)-specific ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to poly(A)-specific ribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis, exonucleolytic IEA
Inferred from Electronic Annotation
more info
 
deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
nuclear-transcribed mRNA poly(A) tail shortening IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear-transcribed mRNA poly(A) tail shortening TAS
Traceable Author Statement
more info
 
positive regulation of cytoplasmic mRNA processing body assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein targeting IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
P-body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
PAN complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
PAN complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
PAN2-PAN3 deadenylation complex subunit PAN3
Names
PAB-dependent poly(A)-specific ribonuclease subunit 3
PAB-dependent poly(A)-specific ribonuclease subunit PAN3
PAB1P-dependent poly(A)-nuclease
PAB1P-dependent poly(A)-specific ribonuclease
PABP-dependent poly(A) nuclease 3
PABP1-dependent poly A-specific ribonuclease subunit PAN3
PAN deadenylation complex subunit 3
PAN3 poly(A) specific ribonuclease subunit homolog
poly(A)-nuclease deadenylation complex subunit 3
NP_787050.6
XP_005266389.1
XP_005266390.1
XP_005266391.1
XP_011533334.1
XP_011533335.1
XP_011533336.1
XP_016876017.1
XP_016876018.1
XP_016876019.1
XP_016876020.1
XP_016876021.1
XP_016876022.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175854.8NP_787050.6  PAN2-PAN3 deadenylation complex subunit PAN3

    See identical proteins and their annotated locations for NP_787050.6

    Status: VALIDATED

    Source sequence(s)
    AB109552, AK296435, AL138712, BE671612
    Consensus CDS
    CCDS9329.2
    UniProtKB/Swiss-Prot
    Q58A45
    Related
    ENSP00000370345.3, ENST00000380958.8
    Conserved Domains (2) summary
    pfam00642
    Location:4968
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl21453
    Location:493661
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    28135021..28295335
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535034.3XP_011533336.1  PAN2-PAN3 deadenylation complex subunit PAN3 isoform X5

    Conserved Domains (1) summary
    cl21453
    Location:347515
    PKc_like; Protein Kinases, catalytic domain
  2. XM_017020529.2XP_016876018.1  PAN2-PAN3 deadenylation complex subunit PAN3 isoform X7

    Conserved Domains (1) summary
    cl21453
    Location:267435
    PKc_like; Protein Kinases, catalytic domain
  3. XM_017020530.2XP_016876019.1  PAN2-PAN3 deadenylation complex subunit PAN3 isoform X8

    Related
    ENST00000503791.5
  4. XM_005266332.3XP_005266389.1  PAN2-PAN3 deadenylation complex subunit PAN3 isoform X1

    Conserved Domains (2) summary
    pfam00642
    Location:4968
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl21453
    Location:492660
    PKc_like; Protein Kinases, catalytic domain
  5. XM_011535032.3XP_011533334.1  PAN2-PAN3 deadenylation complex subunit PAN3 isoform X3

    Conserved Domains (2) summary
    pfam00642
    Location:4968
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl21453
    Location:493661
    PKc_like; Protein Kinases, catalytic domain
  6. XM_011535033.2XP_011533335.1  PAN2-PAN3 deadenylation complex subunit PAN3 isoform X4

    Conserved Domains (2) summary
    pfam00642
    Location:4968
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl21453
    Location:493661
    PKc_like; Protein Kinases, catalytic domain
  7. XM_017020528.1XP_016876017.1  PAN2-PAN3 deadenylation complex subunit PAN3 isoform X6

  8. XM_017020533.1XP_016876022.1  PAN2-PAN3 deadenylation complex subunit PAN3 isoform X11

    UniProtKB/Swiss-Prot
    Q58A45
    Conserved Domains (1) summary
    cl21453
    Location:159327
    PKc_like; Protein Kinases, catalytic domain
  9. XM_005266333.3XP_005266390.1  PAN2-PAN3 deadenylation complex subunit PAN3 isoform X2

    UniProtKB/Swiss-Prot
    Q58A45
    Related
    ENSP00000382522.1, ENST00000399613.1
    Conserved Domains (2) summary
    pfam00642
    Location:4968
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl21453
    Location:439607
    PKc_like; Protein Kinases, catalytic domain
  10. XM_017020532.1XP_016876021.1  PAN2-PAN3 deadenylation complex subunit PAN3 isoform X10

    UniProtKB/Swiss-Prot
    Q58A45
    Conserved Domains (1) summary
    cl21453
    Location:181349
    PKc_like; Protein Kinases, catalytic domain
  11. XM_005266334.1XP_005266391.1  PAN2-PAN3 deadenylation complex subunit PAN3 isoform X10

    UniProtKB/Swiss-Prot
    Q58A45
    Conserved Domains (1) summary
    cl21453
    Location:181349
    PKc_like; Protein Kinases, catalytic domain
  12. XM_017020531.1XP_016876020.1  PAN2-PAN3 deadenylation complex subunit PAN3 isoform X9

RNA

  1. XR_941549.2 RNA Sequence

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