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Pan3 PAN3 poly(A) specific ribonuclease subunit [ Mus musculus (house mouse) ]

Gene ID: 72587, updated on 26-Sep-2022

Summary

Official Symbol
Pan3provided by MGI
Official Full Name
PAN3 poly(A) specific ribonuclease subunitprovided by MGI
Primary source
MGI:MGI:1919837
See related
Ensembl:ENSMUSG00000029647 AllianceGenome:MGI:1919837
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2700050F09Rik; A430027N15Rik
Summary
Predicted to enable poly(A) binding activity. Predicted to contribute to poly(A)-specific ribonuclease activity. Acts upstream of or within deadenylation-dependent decapping of nuclear-transcribed mRNA; positive regulation of cytoplasmic mRNA processing body assembly; and protein targeting. Located in P-body. Orthologous to human PAN3 (poly(A) specific ribonuclease subunit PAN3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 13.1), bladder adult (RPKM 8.2) and 28 other tissues See more
Orthologs
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Genomic context

See Pan3 in Genome Data Viewer
Location:
5; 5 G3
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (147363018..147485311)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (147426208..147548501)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene DNA segment, Chr 5, ERATO Doi 605, expressed Neighboring gene predicted gene, 29793 Neighboring gene FMS-like tyrosine kinase 1 Neighboring gene predicted gene, 35383 Neighboring gene predicted gene, 35541

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC99847, MGC102350

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to poly(A)-specific ribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in P-body IDA
Inferred from Direct Assay
more info
PubMed 
part_of PAN complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of PAN complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
PAN2-PAN3 deadenylation complex subunit Pan3
Names
PAB-dependent poly(A)-specific ribonuclease subunit 3
PAB1P-dependent poly(A)-specific ribonuclease
PAN3 polyA specific ribonuclease subunit homolog
Pabp-dependent poly(A) nuclease 3
Pabp1-dependent poly A-specific ribonuclease subunit Pan3
poly(A)-nuclease deadenylation complex subunit 3
NP_001346362.1
NP_082567.3
XP_006504931.1
XP_006504932.1
XP_006504933.1
XP_006504934.1
XP_006504935.1
XP_006504936.1
XP_006504940.1
XP_006504941.1
XP_017176602.1
XP_030110691.1
XP_036021422.1
XP_036021423.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359433.1NP_001346362.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate internal exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC131730, AC134441, BC082547
    Conserved Domains (2) summary
    pfam18101
    Location:430567
    Pan3_PK; Pan3 Pseudokinase domain
    cl21453
    Location:181349
    PKc_like; Protein Kinases, catalytic domain
  2. NM_028291.5NP_082567.3  PAN2-PAN3 deadenylation complex subunit Pan3 isoform 1

    See identical proteins and their annotated locations for NP_082567.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC131730, AC134441
    Consensus CDS
    CCDS39401.2
    UniProtKB/Swiss-Prot
    Q640Q5, Q9CZM6
    Related
    ENSMUSP00000031651.9, ENSMUST00000031651.15
    Conserved Domains (2) summary
    pfam00642
    Location:5574
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl21453
    Location:439607
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    147363018..147485311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504872.4XP_006504935.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X5

    Conserved Domains (3) summary
    pfam00642
    Location:5574
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam18101
    Location:742852
    Pan3_PK; Pan3 Pseudokinase domain
    cl21453
    Location:493661
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006504870.5XP_006504933.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X3

    UniProtKB/TrEMBL
    H3BKF3
    Related
    ENSMUSP00000135367.2, ENSMUST00000176600.8
    Conserved Domains (3) summary
    pfam00642
    Location:5574
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam18101
    Location:742879
    Pan3_PK; Pan3 Pseudokinase domain
    cl21453
    Location:493661
    PKc_like; Protein Kinases, catalytic domain
  3. XM_006504868.4XP_006504931.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X1

    Conserved Domains (3) summary
    pfam00642
    Location:5574
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam18101
    Location:742879
    Pan3_PK; Pan3 Pseudokinase domain
    cl21453
    Location:493661
    PKc_like; Protein Kinases, catalytic domain
  4. XM_017321113.2XP_017176602.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X6

    Conserved Domains (3) summary
    pfam00642
    Location:5574
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam18101
    Location:703840
    Pan3_PK; Pan3 Pseudokinase domain
    cl21453
    Location:571694
    PKc_like; Protein Kinases, catalytic domain
  5. XM_006504869.4XP_006504932.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X2

    Conserved Domains (3) summary
    pfam00642
    Location:5574
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam18101
    Location:741878
    Pan3_PK; Pan3 Pseudokinase domain
    cl21453
    Location:492660
    PKc_like; Protein Kinases, catalytic domain
  6. XM_036165529.1XP_036021422.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X7

    Conserved Domains (3) summary
    pfam00642
    Location:5574
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam18101
    Location:649786
    Pan3_PK; Pan3 Pseudokinase domain
    cl21453
    Location:517640
    PKc_like; Protein Kinases, catalytic domain
  7. XM_036165530.1XP_036021423.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X9

    Conserved Domains (2) summary
    pfam18101
    Location:430567
    Pan3_PK; Pan3 Pseudokinase domain
    cl21453
    Location:181349
    PKc_like; Protein Kinases, catalytic domain
  8. XM_006504878.4XP_006504941.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X11

    Conserved Domains (2) summary
    pfam18101
    Location:408545
    Pan3_PK; Pan3 Pseudokinase domain
    cl21453
    Location:159327
    PKc_like; Protein Kinases, catalytic domain
  9. XM_006504873.4XP_006504936.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X8

    Conserved Domains (3) summary
    pfam00642
    Location:5574
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam18101
    Location:556693
    Pan3_PK; Pan3 Pseudokinase domain
    cl21453
    Location:307475
    PKc_like; Protein Kinases, catalytic domain
  10. XM_006504871.4XP_006504934.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X4

    Conserved Domains (3) summary
    pfam00642
    Location:5574
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam18101
    Location:718855
    Pan3_PK; Pan3 Pseudokinase domain
    cl21453
    Location:469637
    PKc_like; Protein Kinases, catalytic domain
  11. XM_006504877.4XP_006504940.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X10

    Related
    ENSMUSP00000135729.2, ENSMUST00000175807.8
    Conserved Domains (2) summary
    pfam18101
    Location:411548
    Pan3_PK; Pan3 Pseudokinase domain
    cl21453
    Location:162330
    PKc_like; Protein Kinases, catalytic domain
  12. XM_030254831.2XP_030110691.1  PAN2-PAN3 deadenylation complex subunit Pan3 isoform X9

    Conserved Domains (2) summary
    pfam18101
    Location:430567
    Pan3_PK; Pan3 Pseudokinase domain
    cl21453
    Location:181349
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_004942572.1 RNA Sequence

  2. XR_004942573.1 RNA Sequence

  3. XR_004942570.1 RNA Sequence

  4. XR_004942571.1 RNA Sequence

  5. XR_004942574.1 RNA Sequence

  6. XR_004942575.1 RNA Sequence

    Related
    ENSMUST00000176596.8