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    C3AR1 complement C3a receptor 1 [ Homo sapiens (human) ]

    Gene ID: 719, updated on 2-Nov-2024

    Summary

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    Official Symbol
    C3AR1provided by HGNC
    Official Full Name
    complement C3a receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:1319
    See related
    Ensembl:ENSG00000171860 MIM:605246; AllianceGenome:HGNC:1319
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AZ3B; C3AR; HNFAG09
    Summary
    C3a is an anaphylatoxin released during activation of the complement system. The protein encoded by this gene is an orphan G protein-coupled receptor for C3a. Binding of C3a by the encoded receptor activates chemotaxis, granule enzyme release, superoxide anion production, and bacterial opsonization. [provided by RefSeq, May 2016]
    Expression
    Broad expression in appendix (RPKM 43.3), placenta (RPKM 19.2) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See C3AR1 in Genome Data Viewer
    Location:
    12p13.31
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (8056844..8066359, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (8070449..8079963, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (8209440..8218955, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5924 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4206 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5926 Neighboring gene forkhead box J2 Neighboring gene NANOG hESC enhancer GRCh37_chr12:8229725-8230226 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:8234132-8235331 Neighboring gene NECAP endocytosis associated 1 Neighboring gene C-type lectin domain family 4 member A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5929 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:8286281-8287059 Neighboring gene POU class 5 homeobox 1 pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure. Roglic A, et al. Biochim Biophys Acta, 1996 Feb 7. PMID 8605247
    2. Decreased expression of complement 3a receptor (C3aR) in human placentas from severe preeclamptic pregnancies. Lim R, et al. Eur J Obstet Gynecol Reprod Biol, 2012 Dec. PMID 22901903
    3. C3aR1 gene overexpressed at initial stage of acute myeloid leukemia-M2 predicting short-term survival. Wu SY, et al. Leuk Lymphoma, 2015 Jul. PMID 25426664
    4. The TLQP-21 peptide activates the G-protein-coupled receptor C3aR1 via a folding-upon-binding mechanism. Cero C, et al. Structure, 2014 Dec 2. PMID 25456411, Free PMC Article
    5. Regulation of C3a receptor signaling in human mast cells by G protein coupled receptor kinases. Guo Q, et al. PLoS One, 2011. PMID 21799898, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Complement 3a induces the synapse loss via C3aR in mitochondria-dependent NLRP3 activating mechanisms during the development and progression of Alzheimer's disease.
      Title: Complement 3a induces the synapse loss via C3aR in mitochondria-dependent NLRP3 activating mechanisms during the development and progression of Alzheimer's disease.
    2. C3aR-initiated signaling is a critical mechanism of podocyte injury in membranous nephropathy.
      Title: C3aR-initiated signaling is a critical mechanism of podocyte injury in membranous nephropathy.
    3. Deficiency of Complement C3a and C5a receptors Does Not Prevent Angiotensin II-Induced Hypertension and Hypertensive End-Organ Damage.
      Title: Deficiency of Complement C3a and C5a receptors Does Not Prevent Angiotensin II-Induced Hypertension and Hypertensive End-Organ Damage.
    4. Molecular signatures of intrarenal complement receptors C3AR1 and C5AR1 correlate with renal outcome in human lupus nephritis.
      Title: Molecular signatures of intrarenal complement receptors C3AR1 and C5AR1 correlate with renal outcome in human lupus nephritis.
    5. The Complement C3a-C3a Receptor Axis Regulates Epithelial-to-Mesenchymal Transition by Activating the ERK Pathway in Pancreatic Ductal Adenocarcinoma.
      Title: The Complement C3a-C3a Receptor Axis Regulates Epithelial-to-Mesenchymal Transition by Activating the ERK Pathway in Pancreatic Ductal Adenocarcinoma.
    6. Identification and characterization of prognosis-related genes in the tumor microenvironment of esophageal squamous cell carcinoma.
      Title: Identification and characterization of prognosis-related genes in the tumor microenvironment of esophageal squamous cell carcinoma.
    7. Down-Regulation of C3aR/C5aR Inhibits Cell Proliferation and EMT in Hepatocellular Carcinoma.
      Title: Down-Regulation of C3aR/C5aR Inhibits Cell Proliferation and EMT in Hepatocellular Carcinoma.
    8. Mitochondrial C3a Receptor Activation in Oxidatively Stressed Epithelial Cells Reduces Mitochondrial Respiration and Metabolism.
      Title: Mitochondrial C3a Receptor Activation in Oxidatively Stressed Epithelial Cells Reduces Mitochondrial Respiration and Metabolism.
    9. Changes in VGF and C3aR1 gene expression in human adipose tissue in obesity.
      Title: Changes in VGF and C3aR1 gene expression in human adipose tissue in obesity.
    10. High Expression of the Component 3a Receptor 1 (C3AR1) Gene in Stomach Adenocarcinomas Infers a Poor Prognosis and High Immune-Infiltration Levels.
      Title: High Expression of the Component 3a Receptor 1 (C3AR1) Gene in Stomach Adenocarcinomas Infers a Poor Prognosis and High Immune-Infiltration Levels.
    Submit: New GeneRIF Correction See all GeneRIFs (49)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr upregulates the gene expression of C3AR1 in human monocyte-derived dendritic cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables complement component C3a receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables complement component C3a receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables complement component C5a receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in blood circulation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within_positive_effect calcium-mediated signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within_positive_effect calcium-mediated signaling IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in complement component C5a signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in complement receptor mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in complement receptor mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of macrophage chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of neutrophil chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of vascular endothelial growth factor production IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in azurophil granule membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in specific granule membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    C3a anaphylatoxin chemotactic receptor
    Names
    complement component 3 receptor 1
    complement component 3a receptor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050736.1 RefSeqGene

      Range
      5113..14628
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001326475.2 → NP_001313404.1  C3a anaphylatoxin chemotactic receptor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AC006511, BU074964, DB274838
      Consensus CDS
      CCDS8588.1
      UniProtKB/Swiss-Prot
      O43771, Q16581, Q92868
      UniProtKB/TrEMBL
      A8K2H7, Q53FA1
      Conserved Domains (1) summary
      cd15115
      Location:24 → 446
      7tmA_C3aR; complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001326477.2 → NP_001313406.1  C3a anaphylatoxin chemotactic receptor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AC006511, BU074964, DA351375, DB013722
      Consensus CDS
      CCDS8588.1
      UniProtKB/Swiss-Prot
      O43771, Q16581, Q92868
      UniProtKB/TrEMBL
      A8K2H7, Q53FA1
      Conserved Domains (1) summary
      cd15115
      Location:24 → 446
      7tmA_C3aR; complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_004054.4 → NP_004045.1  C3a anaphylatoxin chemotactic receptor

      See identical proteins and their annotated locations for NP_004045.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. All three variants encode the same protein.
      Source sequence(s)
      AC006511, BC020742, BU074964
      Consensus CDS
      CCDS8588.1
      UniProtKB/Swiss-Prot
      O43771, Q16581, Q92868
      UniProtKB/TrEMBL
      A8K2H7, Q53FA1
      Related
      ENSP00000302079.4, ENST00000307637.5
      Conserved Domains (1) summary
      cd15115
      Location:24 → 446
      7tmA_C3aR; complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      8056844..8066359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      8070449..8079963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q16581.2 GenPept UniProtKB/Swiss-Prot:Q16581

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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