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    Trak2 trafficking protein, kinesin binding 2 [ Mus musculus (house mouse) ]

    Gene ID: 70827, updated on 5-Jun-2018

    Summary

    Official Symbol
    Trak2provided by MGI
    Official Full Name
    trafficking protein, kinesin binding 2provided by MGI
    Primary source
    MGI:MGI:1918077
    See related
    Ensembl:ENSMUSG00000026028 Vega:OTTMUSG00000037699
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GRIF1; OIP98; CALS-C; GRIF-1; Als2cr3; AI480836; AW046271; mKIAA0549; 2900022D04Rik; 4733401O11Rik
    Expression
    Ubiquitous expression in liver E14 (RPKM 25.9), liver E14.5 (RPKM 25.0) and 27 other tissues See more
    Orthologs

    Genomic context

    See Trak2 in Genome Data Viewer
    Location:
    1; 1 C1.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (58900449..58973482, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (58957294..59030326, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene caspase 8 Neighboring gene predicted gene 28802 Neighboring gene STE20-related kinase adaptor beta Neighboring gene C2 calcium dependent domain containing 6B Neighboring gene predicted gene 29018

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    • GABAergic synapse, organism-specific biosystem (from KEGG)
      GABAergic synapse, organism-specific biosystemGamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes o...
    • GABAergic synapse, conserved biosystem (from KEGG)
      GABAergic synapse, conserved biosystemGamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes o...
    • Metabolic pathways, organism-specific biosystem (from KEGG)
      Metabolic pathways, organism-specific biosystem
      Metabolic pathways

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GABA receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GABA receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    TPR domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinesin binding ISO
    Inferred from Sequence Orthology
    more info
     
    myosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    anterograde axonal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    anterograde axonal transport of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    anterograde dendritic transport of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic transport of mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion distribution IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein O-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein targeting IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein targeting ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    axonal growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dendrite IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dendrite cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    colocalizes_with early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    trafficking kinesin-binding protein 2
    Names
    amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172406.3NP_765994.2  trafficking kinesin-binding protein 2

      See identical proteins and their annotated locations for NP_765994.2

      Status: VALIDATED

      Source sequence(s)
      AK036650, AK053848, BC060681, CJ116609
      Consensus CDS
      CCDS14980.1
      UniProtKB/TrEMBL
      Q6P9N8, Q8BKA2, Q8BZ57
      Related
      ENSMUSP00000027186.5, OTTMUSP00000054610, ENSMUST00000027186.11, OTTMUST00000097369
      Conserved Domains (3) summary
      pfam04849
      Location:50353
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:426565
      Milton; Kinesin associated protein
      pfam15272
      Location:210353
      BBP1_C; Spindle pole body component BBP1, C-terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      58900449..58973482 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496280.2XP_006496343.1  trafficking kinesin-binding protein 2 isoform X2

      Conserved Domains (3) summary
      pfam04849
      Location:50353
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:426565
      Milton; Kinesin associated protein
      pfam15272
      Location:210353
      BBP1_C; Spindle pole body component BBP1, C-terminal
    2. XM_017312290.1XP_017167779.1  trafficking kinesin-binding protein 2 isoform X5

    3. XM_011238600.2XP_011236902.1  trafficking kinesin-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011236902.1

      UniProtKB/TrEMBL
      Q6P9N8
      Conserved Domains (3) summary
      pfam04849
      Location:50353
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:426565
      Milton; Kinesin associated protein
      pfam15272
      Location:210353
      BBP1_C; Spindle pole body component BBP1, C-terminal
    4. XM_006496281.3XP_006496344.1  trafficking kinesin-binding protein 2 isoform X3

      Conserved Domains (3) summary
      pfam12448
      Location:361500
      Milton; Kinesin associated protein
      pfam15272
      Location:145288
      BBP1_C; Spindle pole body component BBP1, C-terminal
      pfam15619
      Location:144288
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    5. XM_006496282.2XP_006496345.1  trafficking kinesin-binding protein 2 isoform X4

      UniProtKB/TrEMBL
      G3UYW9
      Related
      ENSMUSP00000134253.1, OTTMUSP00000054611, ENSMUST00000174120.1, OTTMUST00000097370
      Conserved Domains (2) summary
      pfam04849
      Location:50353
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:426565
      Milton; Kinesin associated protein
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