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    Trak2 trafficking protein, kinesin binding 2 [ Mus musculus (house mouse) ]

    Gene ID: 70827, updated on 23-Jun-2021

    Summary

    Official Symbol
    Trak2provided by MGI
    Official Full Name
    trafficking protein, kinesin binding 2provided by MGI
    Primary source
    MGI:MGI:1918077
    See related
    Ensembl:ENSMUSG00000026028
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OI; Als; CAL; GRI; GRIF; GRIF1; OIP98; CALS-C; GRIF-1; Als2cr3; AI480836; AW046271; mKIAA0549; 2900022D04Rik; 4733401O11Rik
    Expression
    Ubiquitous expression in liver E14 (RPKM 25.9), liver E14.5 (RPKM 25.0) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Trak2 in Genome Data Viewer
    Location:
    1; 1 C1.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58939608..59013509, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58900449..58974345, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (58957294..59030326, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene caspase 8 Neighboring gene predicted gene 28802 Neighboring gene STE20-related kinase adaptor beta Neighboring gene C2 calcium dependent domain containing 6 Neighboring gene predicted gene 29018 Neighboring gene predicted gene, 25502

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GABA receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GABA receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables TPR domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables myosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in anterograde axonal transport of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in anterograde dendritic transport of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dendritic transport of mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrion distribution IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein O-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein targeting IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein targeting ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axonal growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    trafficking kinesin-binding protein 2
    Names
    amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172406.3NP_765994.2  trafficking kinesin-binding protein 2

      See identical proteins and their annotated locations for NP_765994.2

      Status: VALIDATED

      Source sequence(s)
      AK036650, AK053848, BC060681, CJ116609
      Consensus CDS
      CCDS14980.1
      UniProtKB/TrEMBL
      Q6P9N8, Q8BKA2, Q8BZ57
      Related
      ENSMUSP00000027186.6, ENSMUST00000027186.12
      Conserved Domains (2) summary
      pfam04849
      Location:50353
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:414565
      Milton; Kinesin associated protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      58939608..59013509 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153623.1XP_036009516.1  trafficking kinesin-binding protein 2 isoform X1

      Conserved Domains (2) summary
      pfam04849
      Location:50372
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:433584
      Milton; Kinesin associated protein
    2. XM_006496280.4XP_006496343.1  trafficking kinesin-binding protein 2 isoform X4

      Conserved Domains (2) summary
      pfam04849
      Location:50353
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:414565
      Milton; Kinesin associated protein
    3. XM_036153625.1XP_036009518.1  trafficking kinesin-binding protein 2 isoform X1

      Conserved Domains (2) summary
      pfam04849
      Location:50372
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:433584
      Milton; Kinesin associated protein
    4. XM_036153639.1XP_036009532.1  trafficking kinesin-binding protein 2 isoform X7

      Conserved Domains (2) summary
      pfam04849
      Location:24288
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:349500
      Milton; Kinesin associated protein
    5. XM_006496281.5XP_006496344.1  trafficking kinesin-binding protein 2 isoform X6

      Conserved Domains (3) summary
      cl29994
      Location:694734
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
      pfam04849
      Location:24288
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:349500
      Milton; Kinesin associated protein
    6. XM_036153638.1XP_036009531.1  trafficking kinesin-binding protein 2 isoform X5

      Conserved Domains (2) summary
      pfam04849
      Location:24307
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:368519
      Milton; Kinesin associated protein
    7. XM_036153627.1XP_036009520.1  trafficking kinesin-binding protein 2 isoform X2

      Conserved Domains (2) summary
      pfam04849
      Location:50372
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:433584
      Milton; Kinesin associated protein
    8. XM_036153640.1XP_036009533.1  trafficking kinesin-binding protein 2 isoform X8

      Conserved Domains (2) summary
      pfam04849
      Location:50372
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:433584
      Milton; Kinesin associated protein
    9. XM_030242947.2XP_030098807.1  trafficking kinesin-binding protein 2 isoform X3

      Conserved Domains (2) summary
      pfam04849
      Location:50353
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:414565
      Milton; Kinesin associated protein
    10. XM_036153630.1XP_036009523.1  trafficking kinesin-binding protein 2 isoform X3

      Conserved Domains (2) summary
      pfam04849
      Location:50353
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:414565
      Milton; Kinesin associated protein
    11. XM_036153641.1XP_036009534.1  trafficking kinesin-binding protein 2 isoform X9

      Related
      ENSMUSP00000134253.2, ENSMUST00000174120.2
      Conserved Domains (2) summary
      pfam04849
      Location:50353
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:414565
      Milton; Kinesin associated protein
    12. XM_006496282.4XP_006496345.1  trafficking kinesin-binding protein 2 isoform X9

      UniProtKB/TrEMBL
      G3UYW9
      Conserved Domains (2) summary
      pfam04849
      Location:50353
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:414565
      Milton; Kinesin associated protein
    13. XM_036153642.1XP_036009535.1  trafficking kinesin-binding protein 2 isoform X10

      Conserved Domains (2) summary
      pfam04849
      Location:24288
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:349500
      Milton; Kinesin associated protein
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