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TRAK2 trafficking kinesin protein 2 [ Homo sapiens (human) ]

Gene ID: 66008, updated on 5-Aug-2022

Summary

Official Symbol
TRAK2provided by HGNC
Official Full Name
trafficking kinesin protein 2provided by HGNC
Primary source
HGNC:HGNC:13206
See related
Ensembl:ENSG00000115993 MIM:607334; AllianceGenome:HGNC:13206
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRIF1; MILT2; OIP98; CALS-C; GRIF-1; ALS2CR3
Summary
Predicted to enable GABA receptor binding activity and myosin binding activity. Predicted to be involved in several processes, including mitochondrion distribution; organelle transport along microtubule; and protein targeting. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytoplasmic vesicle; dendrite; and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart (RPKM 26.1), thyroid (RPKM 23.5) and 25 other tissues See more
Orthologs
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Genomic context

See TRAK2 in Genome Data Viewer
Location:
2q33.1
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (201377207..201451458, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (201857884..201932241, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (202241930..202316181, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene caspase 8 Neighboring gene flagellum associated containing coiled-coil domains 1 Neighboring gene SCYL2 pseudogene 1 Neighboring gene STE20 related adaptor beta Neighboring gene uncharacterized LOC124906113 Neighboring gene C2 calcium dependent domain containing 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0549

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GABA receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GABA receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
enables myosin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in anterograde axonal transport of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in anterograde dendritic transport of mitochondrion IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrion distribution IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein targeting IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
trafficking kinesin-binding protein 2
Names
O-linked N-acetylglucosamine transferase interacting protein 98
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3
amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein
gamma-aminobutyric acid(A) receptor-interacting factor
milton homolog 2
trafficking protein, kinesin binding 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015049.3NP_055864.2  trafficking kinesin-binding protein 2

    See identical proteins and their annotated locations for NP_055864.2

    Status: VALIDATED

    Source sequence(s)
    AB011121, AB038951, AC007256, CA396280, DA314514, DA414989, DA575492
    Consensus CDS
    CCDS2347.1
    UniProtKB/Swiss-Prot
    O60296, Q9C0K6
    Related
    ENSP00000328875.3, ENST00000332624.8
    Conserved Domains (2) summary
    pfam04849
    Location:50353
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:427567
    Milton; Kinesin associated protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    201377207..201451458 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445578.1XP_047301534.1  trafficking kinesin-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9C0K6
  2. XM_047445579.1XP_047301535.1  trafficking kinesin-binding protein 2 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    201857884..201932241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)