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    Gcc2 GRIP and coiled-coil domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 70297, updated on 23-Jun-2021

    Summary

    Official Symbol
    Gcc2provided by MGI
    Official Full Name
    GRIP and coiled-coil domain containing 2provided by MGI
    Primary source
    MGI:MGI:1917547
    See related
    Ensembl:ENSMUSG00000038039
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW112121; mKIAA0336; 0610043A03Rik; 2210420P05Rik; 2600014C01Rik
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 5.2), frontal lobe adult (RPKM 5.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Gcc2 in Genome Data Viewer
    Location:
    10; 10 B4
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (58091217..58141421)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (58255408..58305599)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (57718274..57768340)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene 4981 Neighboring gene predicted gene 9919 Neighboring gene LIM and senescent cell antigen-like domains 1 Neighboring gene predicted gene, 23058 Neighboring gene RAN binding protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi ribbon formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in late endosome to Golgi transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in late endosome to Golgi transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule anchoring ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule organizing center organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein targeting to lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in recycling endosome to Golgi transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein exit from endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    GRIP and coiled-coil domain-containing protein 2
    Names
    185 kDa Golgi coiled-coil protein
    GCC185

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027375.2NP_081651.2  GRIP and coiled-coil domain-containing protein 2

      See identical proteins and their annotated locations for NP_081651.2

      Status: VALIDATED

      Source sequence(s)
      AB093232, BC065697, BY741402
      Consensus CDS
      CCDS23859.1
      UniProtKB/TrEMBL
      B2RSU7, Q6P0A4
      Related
      ENSMUSP00000054033.8, ENSMUST00000057659.14
      Conserved Domains (4) summary
      TIGR02168
      Location:6241386
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01465
      Location:16101652
      GRIP; GRIP domain
      pfam07851
      Location:104203
      TMPIT; TMPIT-like protein
      pfam16704
      Location:15441608
      Rab_bind; Rab binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      58091217..58141421
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155993.1XP_036011886.1  GRIP and coiled-coil domain-containing protein 2 isoform X1

      Related
      ENSMUSP00000124152.2, ENSMUST00000162860.8
      Conserved Domains (4) summary
      COG1196
      Location:2271044
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:6541370
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16704
      Location:14441508
      Rab_bind; Rab binding domain
      pfam01465
      Location:15101552
      GRIP; GRIP domain
    2. XM_036155994.1XP_036011887.1  GRIP and coiled-coil domain-containing protein 2 isoform X2

      Conserved Domains (4) summary
      COG1196
      Location:15274
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:165470
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16704
      Location:544608
      Rab_bind; Rab binding domain
      pfam01465
      Location:610652
      GRIP; GRIP domain

    RNA

    1. XR_004936270.1 RNA Sequence

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