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GCC2 GRIP and coiled-coil domain containing 2 [ Homo sapiens (human) ]

Gene ID: 9648, updated on 22-Mar-2020

Summary

Official Symbol
GCC2provided by HGNC
Official Full Name
GRIP and coiled-coil domain containing 2provided by HGNC
Primary source
HGNC:HGNC:23218
See related
Ensembl:ENSG00000135968 MIM:612711
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
REN53; GCC185; RANBP2L4
Summary
The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
Expression
Ubiquitous expression in gall bladder (RPKM 11.9), thyroid (RPKM 11.7) and 25 other tissues See more
Orthologs

Genomic context

See GCC2 in Genome Data Viewer
Location:
2q12.3
Exon count:
25
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (108448561..108509415)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (109065577..109125854)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene sulfotransferase family 1C member 4 Neighboring gene small integral membrane protein 12 pseudogene 1 Neighboring gene 2q12.3 distal recombination region Neighboring gene GCC2 antisense RNA 1 Neighboring gene LIM zinc finger domain containing 1 Neighboring gene Sharpr-MPRA regulatory region 6630

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef binds GCC2 (GCC185); the N-terminal EEEE65 acidic domain of Nef as the key region for interaction PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0336

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Golgi ribbon formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi ribbon formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT Golgi to plasma membrane protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
late endosome to Golgi transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
late endosome to Golgi transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule anchoring IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule organizing center organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule organizing center organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to Golgi apparatus IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein targeting to lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein targeting to lysosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
recycling endosome to Golgi transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
recycling endosome to Golgi transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein exit from endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of protein exit from endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
PubMed 
retrograde transport, endosome to Golgi IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
GRIP and coiled-coil domain-containing protein 2
Names
185 kDa Golgi coiled-coil protein
CLL-associated antigen KW-11
CTCL tumor antigen se1-1
GCC protein, 185-kD
Golgi coiled-coil protein GCC185
Ran-binding protein 2-like 4
renal carcinoma antigen NY-REN-53

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181453.4NP_852118.2  GRIP and coiled-coil domain-containing protein 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AC012487, AC068941
    Consensus CDS
    CCDS33268.1
    Related
    ENSP00000307939.5, ENST00000309863.11

RNA

  1. NR_028063.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC012487, AC068941
    Related
    ENST00000482325.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    108448561..108509415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712870.3XP_006712933.1  GRIP and coiled-coil domain-containing protein 2 isoform X1

    Conserved Domains (4) summary
    COG1196
    Location:44956
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:7031481
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01465
    Location:16171659
    GRIP; GRIP domain
    pfam16704
    Location:15511615
    Rab_bind; Rab binding domain
  2. XM_006712872.3XP_006712935.1  GRIP and coiled-coil domain-containing protein 2 isoform X4

    Related
    ENSP00000386997.1, ENST00000409896.1
    Conserved Domains (1) summary
    COG1196
    Location:44956
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  3. XM_006712871.1XP_006712934.1  GRIP and coiled-coil domain-containing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006712934.1

    UniProtKB/Swiss-Prot
    Q8IWJ2
    Conserved Domains (4) summary
    COG1196
    Location:17852
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:5991377
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01465
    Location:15131555
    GRIP; GRIP domain
    pfam16704
    Location:14471511
    Rab_bind; Rab binding domain
  4. XM_011512213.2XP_011510515.1  GRIP and coiled-coil domain-containing protein 2 isoform X3

    Conserved Domains (4) summary
    COG1196
    Location:6841
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:5881366
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01465
    Location:15021544
    GRIP; GRIP domain
    pfam16704
    Location:14361500
    Rab_bind; Rab binding domain

RNA

  1. XR_923067.2 RNA Sequence

  2. XR_001739078.1 RNA Sequence

  3. XR_001739079.1 RNA Sequence

  4. XR_001739080.1 RNA Sequence

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