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    Mif4gd MIF4G domain containing [ Mus musculus (house mouse) ]

    Gene ID: 69674, updated on 26-Sep-2022

    Summary

    Official Symbol
    Mif4gdprovided by MGI
    Official Full Name
    MIF4G domain containingprovided by MGI
    Primary source
    MGI:MGI:1916924
    See related
    Ensembl:ENSMUSG00000020743 AllianceGenome:MGI:1916924
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110014L05Rik; 2310075G12Rik
    Summary
    Predicted to enable identical protein binding activity; protein C-terminus binding activity; and translation activator activity. Predicted to be involved in regulation of translational initiation. Predicted to act upstream of or within regulation of translation. Predicted to be located in Golgi apparatus and nucleolus. Predicted to be active in cytosol. Is expressed in several structures, including brain; connective tissue; endocrine gland; genitourinary system; and trachea. Orthologous to human MIF4GD (MIF4G domain containing). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 121.7), adrenal adult (RPKM 65.9) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Mif4gd in Genome Data Viewer
    Location:
    11; 11 E2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115498744..115503795, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115607918..115612969, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene nucleoporin 85 Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 3 Neighboring gene predicted gene, 25364 Neighboring gene mitchondrial ribosomal protein S7 Neighboring gene solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 Neighboring gene growth factor receptor bound protein 2

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cap-dependent translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IC
    Inferred by Curator
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone mRNA stem-loop binding complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    MIF4G domain-containing protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243584.1NP_001230513.1  MIF4G domain-containing protein isoform 1

      See identical proteins and their annotated locations for NP_001230513.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK150749, AL645470, BQ174854
      Consensus CDS
      CCDS25643.1
      UniProtKB/Swiss-Prot
      Q3UBZ5, Q8R333
      UniProtKB/TrEMBL
      A0A8C6ICH1
      Related
      ENSMUSP00000021087.8, ENSMUST00000021087.14
      Conserved Domains (1) summary
      cl02652
      Location:13179
      MIF4G; MIF4G domain
    2. NM_001243586.1NP_001230515.1  MIF4G domain-containing protein isoform 2

      See identical proteins and their annotated locations for NP_001230515.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. Variants 3 and 4 encode isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AL645470
      Consensus CDS
      CCDS56818.1
      UniProtKB/TrEMBL
      A2A9W3
    3. NM_001243587.1NP_001230516.1  MIF4G domain-containing protein isoform 2

      See identical proteins and their annotated locations for NP_001230516.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. Variants 3 and 4 encode isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AL645470
      Consensus CDS
      CCDS56818.1
      UniProtKB/TrEMBL
      A2A9W3
      Related
      ENSMUSP00000102115.2, ENSMUST00000106506.8
      Conserved Domains (1) summary
      cl02652
      Location:13160
      MIF4G; MIF4G domain
    4. NM_027162.4NP_081438.4  MIF4G domain-containing protein isoform 1

      See identical proteins and their annotated locations for NP_081438.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AK150749, AL645470, BQ174854
      Consensus CDS
      CCDS25643.1
      UniProtKB/Swiss-Prot
      Q3UBZ5, Q8R333
      UniProtKB/TrEMBL
      A0A8C6ICH1
      Related
      ENSMUSP00000102116.3, ENSMUST00000106507.9
      Conserved Domains (1) summary
      cl02652
      Location:13179
      MIF4G; MIF4G domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      115498744..115503795 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249229.4XP_011247531.1  MIF4G domain-containing protein isoform X3

      See identical proteins and their annotated locations for XP_011247531.1

      UniProtKB/TrEMBL
      Q8BTE1
      Conserved Domains (1) summary
      cl02652
      Location:16122
      MIF4G; MIF4G domain
    2. XM_036156963.1XP_036012856.1  MIF4G domain-containing protein isoform X2

      UniProtKB/TrEMBL
      A2A9W3
    3. XM_036156962.1XP_036012855.1  MIF4G domain-containing protein isoform X1

      UniProtKB/Swiss-Prot
      Q8R333
      UniProtKB/TrEMBL
      A0A8C6ICH1
      Conserved Domains (1) summary
      cl02652
      Location:13179
      MIF4G; MIF4G domain