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MIF4GD MIF4G domain containing [ Homo sapiens (human) ]

Gene ID: 57409, updated on 3-Oct-2020

Summary

Official Symbol
MIF4GDprovided by HGNC
Official Full Name
MIF4G domain containingprovided by HGNC
Primary source
HGNC:HGNC:24030
See related
Ensembl:ENSG00000125457 MIM:612072
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIFD; AD023; SLIP1
Summary
This gene encodes a protein which interacts with the N-terminus of the stem-loop binding protein (SLBP) and the 3' end of histone mRNA. This interaction facilitates the activation of histone mRNA translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
Expression
Ubiquitous expression in lymph node (RPKM 9.4), bone marrow (RPKM 8.3) and 25 other tissues See more
Orthologs

Genomic context

See MIF4GD in Genome Data Viewer
Location:
17q25.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (75266228..75271292, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73262309..73267373, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene small ubiquitin like modifier 2 Neighboring gene nucleoporin 85 Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 3 Neighboring gene MIF4GD divergent transcript Neighboring gene mitochondrial ribosomal protein S7 Neighboring gene solute carrier family 25 member 19 Neighboring gene growth factor receptor bound protein 2 Neighboring gene ribosomal protein L36a pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC45027

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
positive regulation of translation IEA
Inferred from Electronic Annotation
more info
 
regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
MIF4G domain-containing protein
Names
SLBP (stem loop binding protein)-interacting protein 1
SLBP-interacting protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242498.2NP_001229427.1  MIF4G domain-containing protein isoform 1

    See identical proteins and their annotated locations for NP_001229427.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), as well as variant 6, encodes the longest isoform (1).
    Source sequence(s)
    AC022211, AK300711, BC033759, BI752882
    Consensus CDS
    CCDS58598.1
    UniProtKB/Swiss-Prot
    A9UHW6
    UniProtKB/TrEMBL
    A0A0S2Z5S7
    Related
    ENSP00000462459.1, ENST00000579297.5
    Conserved Domains (1) summary
    cl02652
    Location:75220
    MIF4G; MIF4G domain
  2. NM_001242500.1NP_001229429.1  MIF4G domain-containing protein isoform 2

    See identical proteins and their annotated locations for NP_001229429.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variant 2, encodes isoform (2).
    Source sequence(s)
    AC022211, BC033759, BU190758
    Consensus CDS
    CCDS11719.1
    UniProtKB/Swiss-Prot
    A9UHW6
    UniProtKB/TrEMBL
    A0A0S2Z5T5
    Conserved Domains (1) summary
    cl02652
    Location:68213
    MIF4G; MIF4G domain
  3. NM_001242501.1NP_001229430.1  MIF4G domain-containing protein isoform 4

    See identical proteins and their annotated locations for NP_001229430.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 7-10, encodes isoform (4).
    Source sequence(s)
    BC033759, CA488406
    Consensus CDS
    CCDS56044.1
    UniProtKB/Swiss-Prot
    A9UHW6
    UniProtKB/TrEMBL
    A0A0S2Z5K9
    Related
    ENSP00000484245.1, ENST00000618645.4
    Conserved Domains (1) summary
    cl02652
    Location:8185
    MIF4G; MIF4G domain
  4. NM_001363806.2NP_001350735.1  MIF4G domain-containing protein isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC022211
    Related
    ENSP00000462412.1, ENST00000580571.5
  5. NM_001365751.1NP_001352680.1  MIF4G domain-containing protein isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variant 1, encodes the longest isoform (1).
    Source sequence(s)
    AC022211
    Conserved Domains (1) summary
    cl02652
    Location:75220
    MIF4G; MIF4G domain
  6. NM_001365752.1NP_001352681.1  MIF4G domain-containing protein isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 4 and 8-10, encodes isoform (4).
    Source sequence(s)
    AC022211
    Related
    ENSP00000464448.1, ENST00000580717.5
    Conserved Domains (1) summary
    cl02652
    Location:8185
    MIF4G; MIF4G domain
  7. NM_001365753.1NP_001352682.1  MIF4G domain-containing protein isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 4, 7, 9, and 10, encodes isoform (4).
    Source sequence(s)
    AC022211
    Conserved Domains (1) summary
    cl02652
    Location:8185
    MIF4G; MIF4G domain
  8. NM_001365754.1NP_001352683.1  MIF4G domain-containing protein isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 4, 7, 8, and 10, encodes isoform (4).
    Source sequence(s)
    AC022211
    Conserved Domains (1) summary
    cl02652
    Location:8185
    MIF4G; MIF4G domain
  9. NM_001365755.1NP_001352684.1  MIF4G domain-containing protein isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 4 and 7-9, encodes isoform (4).
    Source sequence(s)
    AC022211
    Conserved Domains (1) summary
    cl02652
    Location:8185
    MIF4G; MIF4G domain
  10. NM_001370592.1NP_001357521.1  MIF4G domain-containing protein isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC022211, AF225422, BP308696
    Related
    ENSP00000321625.8, ENST00000325102.12
    Conserved Domains (1) summary
    cl02652
    Location:8185
    MIF4G; MIF4G domain
  11. NM_020679.4NP_065730.2  MIF4G domain-containing protein isoform 2

    See identical proteins and their annotated locations for NP_065730.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variant 3, encodes isoform (2).
    Source sequence(s)
    AC022211, BC033759, BI752882, BX404175
    Consensus CDS
    CCDS11719.1
    UniProtKB/Swiss-Prot
    A9UHW6
    UniProtKB/TrEMBL
    A0A0S2Z5T5
    Related
    ENSP00000245551.5, ENST00000245551.9
    Conserved Domains (1) summary
    cl02652
    Location:68213
    MIF4G; MIF4G domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    75266228..75271292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024889.2XP_016880378.1  MIF4G domain-containing protein isoform X7

    Related
    ENSP00000498095.1, ENST00000649805.1
  2. XM_017024891.2XP_016880380.1  MIF4G domain-containing protein isoform X7

  3. XM_011525052.2XP_011523354.1  MIF4G domain-containing protein isoform X3

    Conserved Domains (1) summary
    cl02652
    Location:136281
    MIF4G; MIF4G domain
  4. XM_017024888.1XP_016880377.1  MIF4G domain-containing protein isoform X1

  5. XM_017024890.1XP_016880379.1  MIF4G domain-containing protein isoform X7

  6. XM_011525055.2XP_011523357.1  MIF4G domain-containing protein isoform X9

  7. XM_011525054.2XP_011523356.1  MIF4G domain-containing protein isoform X6

  8. XM_017024895.2XP_016880384.1  MIF4G domain-containing protein isoform X10

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