Rab14 RAB14, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab14provided by MGI
Official Full Name: RAB14, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:1915615
See related: Ensembl:ENSMUSG00000026878 Vega:OTTMUSG00000012919
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AI314285; AI649155; 0610030G24Rik; 2810475J17Rik; A830021G03Rik; D030017L14Rik
Expression: Ubiquitous expression in adrenal adult (RPKM 151.4), stomach adult (RPKM 60.7) and 28 other tissues See more
Orthologs: human all

Genomic context

Location:: 2; 2 B

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCm38.p4 (GCF_000001635.24)	2	NC_000068.7 (35180205..35201120, complement)
Build 37.2	previous assembly	MGSCv37 (GCF_000001635.18)	2	NC_000068.6 (35035725..35056640, complement)

Chromosome 2 - NC_000068.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

clear effect of subcutaneous zoledronic acid administration in vivo on the prenylation of Rab1A, Rab5B, Rab7A and Rab14 in mouse peritoneal macrophages, confirming that systemic treatment with bisphosphonate drug can inhibit prenylation in myeloid cells in vivo outside the skeleton.
Title: A highly sensitive prenylation assay reveals in vivo effects of bisphosphonate drug on the Rab prenylome of macrophages outside the skeleton.
Rab14 limits the sorting of Glut4 from endosomes into insulin-sensitive regulated secretory compartments in adipocytes.(
Title: Rab14 limits the sorting of Glut4 from endosomes into insulin-sensitive regulated secretory compartments in adipocytes.
Rab14 activity promotes phagosome maturation during C. albicans infection but is dysregulated on the phagosome in the presence of the invasive hyphal form, which favors fungal survival and escape.
Title: Rab14 regulates maturation of macrophage phagosomes containing the fungal pathogen Candida albicans and outcome of the host-pathogen interaction.
RAB14 functions upstream of RAB10 in the sorting of GLUT4 to the specialized transport vesicles that ferry GLUT4 to the plasma membrane.
Title: Specialized sorting of GLUT4 and its recruitment to the cell surface are independently regulated by distinct Rabs.
the primary role of Rab14 in GLUT4 trafficking is to control the transit of internalised GLUT4 from early endosomes into the Golgi complex, rather than direct GLUT4 translocation to the plasma membrane.
Title: A role for Rab14 in the endocytic trafficking of GLUT4 in 3T3-L1 adipocytes.
The kinesin-3 motor KIF16B/Rab14 complex acts in biosynthetic Golgi-to-endosome traffic of the fibroblast growth factor receptor (FGFR) during early embryonic development.
Title: KIF16B/Rab14 molecular motor complex is critical for early embryonic development by transporting FGF receptor.
Rab14 enables mycobacterial phagosomes to maintain early endosomal characteristics and avoid late endosomal/lysosomal degradative components.
Title: Rab14 is critical for maintenance of Mycobacterium tuberculosis phagosome maturation arrest.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)

Pathways from BioSystems

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AMPK signaling pathway, organism-specific biosystem (from KEGG)
AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
AMPK signaling pathway, conserved biosystem (from KEGG)
AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystem (from WikiPathways)
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Membrane Trafficking, organism-specific biosystem (from REACTOME)
Membrane Trafficking, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
Metabolism of lipids and lipoproteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Neutrophil degranulation, organism-specific biosystem (from REACTOME)
Neutrophil degranulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI Metabolism, organism-specific biosystem (from REACTOME)
PI Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Phospholipid metabolism, organism-specific biosystem (from REACTOME)
Phospholipid metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RAB GEFs exchange GTP for GDP on RABs, organism-specific biosystem (from REACTOME)
RAB GEFs exchange GTP for GDP on RABs, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Synthesis of PIPs at the plasma membrane, organism-specific biosystem (from REACTOME)
Synthesis of PIPs at the plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Translocation of GLUT4 to the plasma membrane, organism-specific biosystem (from REACTOME)
Translocation of GLUT4 to the plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
Vesicle-mediated transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125833 (e-PCR)
- UniSTS:162577

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

AI649155 (e-PCR)
- UniSTS:178615

AA409087 (e-PCR)
- UniSTS:158958

AI314285 (e-PCR)
- UniSTS:158960

Homology

Homologs of the Rab14 gene: The Rab14 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, M.oryzae, N.crassa, and frog.
Orthologs from Annotation Pipeline: 222 organisms have orthologs with human gene Rab14
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
GDP binding	ISO Inferred from Sequence Orthology more info
GTP binding	ISO Inferred from Sequence Orthology more info
GTPase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
GTPase activity	ISO Inferred from Sequence Orthology more info
myosin V binding	ISO Inferred from Sequence Orthology more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
Golgi to endosome transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
Golgi to endosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
Rab protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info	PubMed
apical protein localization	ISO Inferred from Sequence Orthology more info
body fluid secretion	ISO Inferred from Sequence Orthology more info
defense response to bacterium	IEA Inferred from Electronic Annotation more info
endocytic recycling	ISO Inferred from Sequence Orthology more info
fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
phagolysosome assembly involved in apoptotic cell clearance	IBA Inferred from Biological aspect of Ancestor more info	PubMed
phagosome maturation	IEA Inferred from Electronic Annotation more info
protein transport	IEA Inferred from Electronic Annotation more info
regulation of embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of protein localization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
Golgi apparatus	IEA Inferred from Electronic Annotation more info
Golgi stack	ISO Inferred from Sequence Orthology more info
alveolar lamellar body	ISO Inferred from Sequence Orthology more info
anchored component of synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
apical plasma membrane	ISO Inferred from Sequence Orthology more info
cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
cytosol	ISO Inferred from Sequence Orthology more info
early endosome	IBA Inferred from Biological aspect of Ancestor more info	PubMed
early endosome	ISO Inferred from Sequence Orthology more info
endosome	IEA Inferred from Electronic Annotation more info
intracellular	ISO Inferred from Sequence Orthology more info
intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
late endosome	ISO Inferred from Sequence Orthology more info
lysosome	ISO Inferred from Sequence Orthology more info
membrane	IEA Inferred from Electronic Annotation more info
nuclear outer membrane-endoplasmic reticulum membrane network	ISO Inferred from Sequence Orthology more info
perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
phagocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info	PubMed
phagocytic vesicle	ISO Inferred from Sequence Orthology more info
plasma membrane	ISO Inferred from Sequence Orthology more info
recycling endosome	ISO Inferred from Sequence Orthology more info
rough endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
trans-Golgi network	IEA Inferred from Electronic Annotation more info
trans-Golgi network transport vesicle	ISO Inferred from Sequence Orthology more info
transport vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras-related protein Rab-14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.