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RAB14 RAB14, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 51552, updated on 6-Oct-2024

Summary

Official Symbol
RAB14provided by HGNC
Official Full Name
RAB14, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:16524
See related
Ensembl:ENSG00000119396 MIM:612673; AllianceGenome:HGNC:16524
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBP; RAB-14
Summary
RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]).[supplied by OMIM, Mar 2009]
Expression
Ubiquitous expression in brain (RPKM 33.7), lung (RPKM 31.9) and 25 other tissues See more
Orthologs
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Genomic context

See RAB14 in Genome Data Viewer
Location:
9q33.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (121178133..121201869, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (133374160..133397896, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (123940411..123964147, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene complement C5 Neighboring gene uncharacterized LOC124902261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28914 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:123836497-123836693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28915 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20229 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20230 Neighboring gene centriolin Neighboring gene NANOG hESC enhancer GRCh37_chr9:123883693-123884194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28917 Neighboring gene uncharacterized LOC124902357 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20231 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:123963761-123964260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28920 Neighboring gene RNA, 7SL, cytoplasmic 181, pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:123983210-123983860 Neighboring gene gelsolin Neighboring gene ATPase H+ transporting V1 subunit B2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The interaction of RAB11-FIP1C with RAB14 is required for incorporation of HIV-1 Env (gp120/gp41) into virions PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with RAB14; predicted interaction to be relevant to vesicular transport/membrane trafficking PubMed
Envelope transmembrane glycoprotein gp41 env The interaction of RAB11-FIP1C with RAB14 is required for incorporation of HIV-1 Env (gp120/gp41) into virions PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables myosin V binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Golgi to endosome transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in Golgi to endosome transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in Golgi to endosome transport TAS
Traceable Author Statement
more info
PubMed 
involved_in defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in early endosome to Golgi transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in endocytic recycling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in endosomal vesicle fusion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fibroblast growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular transport NAS
Non-traceable Author Statement
more info
PubMed 
involved_in phagolysosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phagosome maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of protein localization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vesicle-mediated transport NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi stack ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in early endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in early endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome membrane TAS
Traceable Author Statement
more info
 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular exosome HDA PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in late endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in lysosomal membrane HDA PubMed 
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nuclear outer membrane-endoplasmic reticulum membrane network ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in phagocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in recycling endosome membrane TAS
Traceable Author Statement
more info
 
located_in rough endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in tertiary granule membrane TAS
Traceable Author Statement
more info
 
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 
located_in trans-Golgi network transport vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
ras-related protein Rab-14
Names
F protein-binding protein 1
bA165P4.3 (member RAS oncogene family)
small GTP binding protein RAB14
NP_057406.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016322.4NP_057406.2  ras-related protein Rab-14

    See identical proteins and their annotated locations for NP_057406.2

    Status: VALIDATED

    Source sequence(s)
    AL137068, AL162081, BC006081, DA404780
    Consensus CDS
    CCDS6827.1
    UniProtKB/Swiss-Prot
    B3KR31, P35287, P61106, Q5JVD4, Q6Q7K5, Q969L0, Q9UI11
    Related
    ENSP00000362946.4, ENST00000373840.9
    Conserved Domains (1) summary
    cd04122
    Location:10175
    Rab14; Rab GTPase family 14 (Rab14)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    121178133..121201869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    133374160..133397896 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)