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RAB14 RAB14, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 51552, updated on 17-Jun-2019

Summary

Official Symbol
RAB14provided by HGNC
Official Full Name
RAB14, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:16524
See related
Ensembl:ENSG00000119396 MIM:612673
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBP; RAB-14
Summary
RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]).[supplied by OMIM, Mar 2009]
Expression
Ubiquitous expression in brain (RPKM 33.7), lung (RPKM 31.9) and 25 other tissues See more
Orthologs

Genomic context

See RAB14 in Genome Data Viewer
Location:
9q33.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (121178133..121201869, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (123940415..123964365, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene C5 3' UTR overlapping transcript 1 Neighboring gene complement C5 Neighboring gene centriolin Neighboring gene RNA, 7SL, cytoplasmic 181, pseudogene Neighboring gene gelsolin Neighboring gene ATPase H+ transporting V1 subunit B2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The interaction of RAB11-FIP1C with RAB14 is required for incorporation of HIV-1 Env (gp120/gp41) into virions PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with RAB14; predicted interaction to be relevant to vesicular transport/membrane trafficking PubMed
Envelope transmembrane glycoprotein gp41 env The interaction of RAB11-FIP1C with RAB14 is required for incorporation of HIV-1 Env (gp120/gp41) into virions PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • PI Metabolism, organism-specific biosystem (from REACTOME)
    PI Metabolism, organism-specific biosystemPhosphatidylinositol (PI), a membrane phospholipid, can be reversibly phosphorylated at the 3, 4, and 5 positions of the inositol ring to generate seven phosphoinositides: phosphatidylinositol 3-phos...
  • Phospholipid metabolism, organism-specific biosystem (from REACTOME)
    Phospholipid metabolism, organism-specific biosystemPhospholipids contain a polar head group and two long-chain fatty acyl moieties, one of which is generally unsaturated. The head group is a glycerol or serine phosphate attached to a polar group such...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • RAB GEFs exchange GTP for GDP on RABs, organism-specific biosystem (from REACTOME)
    RAB GEFs exchange GTP for GDP on RABs, organism-specific biosystemHuman cells have more than 60 RAB proteins that are key regulators of intracellular membrane trafficking. These small GTPases contribute to trafficking specificity by localizing to the membranes of d...
  • RAB geranylgeranylation, organism-specific biosystem (from REACTOME)
    RAB geranylgeranylation, organism-specific biosystemHuman cells have more than 60 RAB proteins that are involved in trafficking of proteins in the endolysosomal system. These small GTPases contribute to trafficking specificity by localizing to the mem...
  • Synthesis of PIPs at the plasma membrane, organism-specific biosystem (from REACTOME)
    Synthesis of PIPs at the plasma membrane, organism-specific biosystemAt the plasma membrane, subsequent phosphorylation of phosphatidylinositol 4-phosphate (PI4P) produces phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (...
  • Translocation of GLUT4 to the plasma membrane, organism-specific biosystem (from REACTOME)
    Translocation of GLUT4 to the plasma membrane, organism-specific biosystemIn adipocytes and myocytes insulin signaling causes intracellular vesicles carrying the GLUT4 (SLC2A4) glucose transporter to translocate to the plasma membrane, allowing the cells to take up glucose...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activity NAS
Non-traceable Author Statement
more info
PubMed 
myosin V binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Golgi to endosome transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi to endosome transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Golgi to endosome transport TAS
Traceable Author Statement
more info
PubMed 
Rab protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
endocytic recycling IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular transport NAS
Non-traceable Author Statement
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
phagolysosome assembly involved in apoptotic cell clearance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol biosynthetic process TAS
Traceable Author Statement
more info
 
regulation of embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein localization IDA
Inferred from Direct Assay
more info
PubMed 
vesicle-mediated transport NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
Golgi stack ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT cilium IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
early endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
early endosome membrane TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
late endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
lysosomal membrane HDA PubMed 
lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear outer membrane-endoplasmic reticulum membrane network ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
phagocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
recycling endosome membrane TAS
Traceable Author Statement
more info
 
rough endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
tertiary granule membrane TAS
Traceable Author Statement
more info
 
trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 
trans-Golgi network transport vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
ras-related protein Rab-14
Names
F protein-binding protein 1
bA165P4.3 (member RAS oncogene family)
small GTP binding protein RAB14

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016322.4NP_057406.2  ras-related protein Rab-14

    See identical proteins and their annotated locations for NP_057406.2

    Status: VALIDATED

    Source sequence(s)
    AL137068, AL162081, BC006081, DA404780
    Consensus CDS
    CCDS6827.1
    UniProtKB/Swiss-Prot
    P61106
    UniProtKB/TrEMBL
    A0A024R845
    Related
    ENSP00000362946.4, ENST00000373840.9
    Conserved Domains (1) summary
    cd04122
    Location:10175
    Rab14; Rab GTPase family 14 (Rab14)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    121178133..121201869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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