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    STC1 stanniocalcin 1 [ Homo sapiens (human) ]

    Gene ID: 6781, updated on 27-Nov-2024

    Summary

    Official Symbol
    STC1provided by HGNC
    Official Full Name
    stanniocalcin 1provided by HGNC
    Primary source
    HGNC:HGNC:11373
    See related
    Ensembl:ENSG00000159167 MIM:601185; AllianceGenome:HGNC:11373
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    STC
    Summary
    This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in endometrium (RPKM 33.6), thyroid (RPKM 19.7) and 14 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See STC1 in Genome Data Viewer
    Location:
    8p21.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (23841929..23854806, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (24116910..24129801, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (23699442..23712319, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986930 Neighboring gene uncharacterized LOC101929258 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:23618596-23619795 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:23641595-23642178 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:23655625-23656824 Neighboring gene uncharacterized LOC124900262 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:23747587-23748786 Neighboring gene uncharacterized LOC107986931 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:23775304-23775840 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:23775841-23776377 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:23778915-23779185 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:23836477-23837459 Neighboring gene Sharpr-MPRA regulatory region 10080 Neighboring gene uncharacterized LOC105379328 Neighboring gene RNA, U1 small nuclear 148, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
    EBI GWAS Catalog
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog
    New loci associated with kidney function and chronic kidney disease.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in bone development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to cAMP IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glucocorticoid stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chondrocyte proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in decidualization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryo implantation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endothelial cell morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in growth plate cartilage axis specification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular calcium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of calcium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_positive_effect negative regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of renal phosphate excretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ossification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of calcium ion import IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cardiac muscle cell contraction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of monoatomic anion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to vitamin D IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029711.1 RefSeqGene

      Range
      5002..17879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003155.3NP_003146.1  stanniocalcin-1 precursor

      See identical proteins and their annotated locations for NP_003146.1

      Status: REVIEWED

      Source sequence(s)
      AC012119, BC029044, U25997
      Consensus CDS
      CCDS6043.1
      UniProtKB/Swiss-Prot
      B4DN22, P52823, Q71UE5
      UniProtKB/TrEMBL
      B2R6I6
      Related
      ENSP00000290271.2, ENST00000290271.7
      Conserved Domains (1) summary
      pfam03298
      Location:6206
      Stanniocalcin; Stanniocalcin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      23841929..23854806 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      24116910..24129801 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)