Stc1 stanniocalcin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stc1provided by MGI
Official Full Name: stanniocalcin 1provided by MGI
Primary source: MGI:MGI:109131
See related: Ensembl:ENSMUSG00000014813 AllianceGenome:MGI:109131
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Stc
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including chondrocyte proliferation; endothelial cell morphogenesis; and regulation of monoatomic ion transport. Predicted to act upstream of with a positive effect on negative regulation of cell migration. Predicted to act upstream of or within intracellular monoatomic anion homeostasis. Located in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; limb; musculoskeletal system; and nervous system. Orthologous to human STC1 (stanniocalcin 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in bladder adult (RPKM 6.1), ovary adult (RPKM 5.7) and 14 other tissues See more
Orthologs: all
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Genomic context

Location:: 14 D2; 14 35.98 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (69266738..69278850)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (69029289..69041401)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exosomes from Adipose Mesenchymal Stem Cells Overexpressing Stanniocalcin-1 Promote Reendothelialization After Carotid Endarterium Mechanical Injury.
Title: Exosomes from Adipose Mesenchymal Stem Cells Overexpressing Stanniocalcin-1 Promote Reendothelialization After Carotid Endarterium Mechanical Injury.
Stanniocalcin 1 is a serum biomarker and potential therapeutic target for HBV-associated liver fibrosis.
Title: Stanniocalcin 1 is a serum biomarker and potential therapeutic target for HBV-associated liver fibrosis.
STAT3 induces breast cancer growth via ANGPTL4, MMP13 and STC1 secretion by cancer associated fibroblasts.
Title: STAT3 induces breast cancer growth via ANGPTL4, MMP13 and STC1 secretion by cancer associated fibroblasts.
Stanniocalcin-1 Protected Astrocytes from Hypoxic Damage Through the AMPK Pathway.
Title: Stanniocalcin-1 Protected Astrocytes from Hypoxic Damage Through the AMPK Pathway.
Stanniocalcin 1 is a phagocytosis checkpoint driving tumor immune resistance.
Title: Stanniocalcin 1 is a phagocytosis checkpoint driving tumor immune resistance.
Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development.
Title: Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development.
STC-1 is a downstream effector molecule in latanoprost signaling that is independent of the F2a receptor, equivalent and non-additive in the early intraocular pressure response in wild-type mice
Title: Stanniocalcin-1 (STC-1), a downstream effector molecule in latanoprost signaling, acts independent of the FP receptor for intraocular pressure reduction.
The results suggest that Stc1 may be a downstream candidate of Gpnmb, and that both genes interact with other genes in a network to develop glaucoma through mechanisms such as apoptosis and oxidative stress.
Title: Investigating a downstream gene of Gpnmb using the systems genetics method.
Latanoprost-induced reduction of intraocular pressure is mediated through the downstream signaling molecule STC-1. When used by itself, STC-1 exhibits ocular hypotensive properties.
Title: Stanniocalcin-1 Is an Ocular Hypotensive Agent and a Downstream Effector Molecule That Is Necessary for the Intraocular Pressure-Lowering Effects of Latanoprost.
STC-1 maybe improve anti-inflammation, anti-oxidant and anti-apoptosis activities by affecting reactive oxygen species -mediated pathways, especially the phospho-modifications of the respective proteins, resulting in the increase of Superoxide dismutase and reduce of capase-3, p53, IL-6 and IFN-gamma.
Title: Stanniocalcin-1 Protects a Mouse Model from Renal Ischemia-Reperfusion Injury by Affecting ROS-Mediated Multiple Signaling Pathways.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1) 1 citation

General gene information

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Markers

D15Got53 (e-PCR)
- UniSTS:111616

PMC179881P1 (e-PCR)
- UniSTS:271662

Stc1 (e-PCR), detects polymorphism
- UniSTS:472922

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bone development	IEA Inferred from Electronic Annotation more info
involved_in bone development	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucocorticoid stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in chondrocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in chondrocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in decidualization	IEA Inferred from Electronic Annotation more info
involved_in embryo implantation	IEA Inferred from Electronic Annotation more info
involved_in endothelial cell morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in endothelial cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in growth plate cartilage axis specification	IEA Inferred from Electronic Annotation more info
involved_in growth plate cartilage axis specification	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within intracellular monoatomic anion homeostasis	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of renal phosphate excretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of renal phosphate excretion	ISO Inferred from Sequence Orthology more info
involved_in ossification	IEA Inferred from Electronic Annotation more info
involved_in ossification	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion import	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle cell contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of cardiac muscle cell contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of monoatomic anion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of monoatomic anion transport	ISO Inferred from Sequence Orthology more info
involved_in response to vitamin D	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: stanniocalcin-1

Names: STC-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.