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    Agtpbp1 ATP/GTP binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 67269, updated on 9-Mar-2019

    Summary

    Official Symbol
    Agtpbp1provided by MGI
    Official Full Name
    ATP/GTP binding protein 1provided by MGI
    Primary source
    MGI:MGI:2159437
    See related
    Ensembl:ENSMUSG00000021557
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    pcd; CCP1; Nna1; nmf243; 1700020N17Rik; 2310001G17Rik; 2900054O13Rik; 4930445M19Rik; 5730402G09Rik
    Expression
    Broad expression in cerebellum adult (RPKM 16.1), cortex adult (RPKM 14.6) and 21 other tissues See more
    Orthologs

    Genomic context

    See Agtpbp1 in Genome Data Viewer
    Location:
    13 B2; 13 31.87 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (59449534..59557366, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (59550896..59658680, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 34721 Neighboring gene predicted gene, 34788 Neighboring gene RIKEN cDNA A230056J06 gene Neighboring gene N(alpha)-acetyltransferase 35, NatC auxiliary subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Clone Names

    • MGC90651, mKIAA1035, 1700020N17Rik, 2310001G17Rik, 2900054O13Rik, 4930445M19Rik, 5730402G09Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metallocarboxypeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    C-terminal protein deglutamylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adult walking behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebellar Purkinje cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebellar Purkinje cell layer development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebellum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    eye photoreceptor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuromuscular process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuromuscular process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neurotransmitter metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    olfactory bulb development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein side chain deglutamylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cytosolic carboxypeptidase 1
    Names
    Purkinje cell degeneration
    nervous system nuclear protein induced by axotomy protein 1
    nuclear ATP/GTP-binding protein
    NP_001041473.1
    NP_001271147.1
    NP_001271148.1
    NP_001271150.1
    NP_075817.2
    XP_006517398.1
    XP_006517399.1
    XP_006517400.1
    XP_006517401.1
    XP_006517402.1
    XP_006517403.1
    XP_006517405.1
    XP_011242857.1
    XP_011242858.1
    XP_011242859.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048008.2NP_001041473.1  cytosolic carboxypeptidase 1 isoform 2

      See identical proteins and their annotated locations for NP_001041473.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons, and uses an alternate 3'-terminal exon, compared to variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK132695, BB707303, CA528796
      Consensus CDS
      CCDS36687.1
      UniProtKB/Swiss-Prot
      Q641K1
      Related
      ENSMUSP00000105456.2, ENSMUST00000109830.8
    2. NM_001284218.1NP_001271147.1  cytosolic carboxypeptidase 1 isoform 2

      See identical proteins and their annotated locations for NP_001271147.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks several exons, and uses an alternate 3'-terminal exon, compared to variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK132695, AK133215, BB707303, CA528796
      Consensus CDS
      CCDS36687.1
      UniProtKB/Swiss-Prot
      Q641K1
      Related
      ENSMUSP00000132697.1, ENSMUST00000171606.8
      Conserved Domains (1) summary
      pfam15576
      Location:451516
      DUF4661; Domain of unknown function (DUF4661)
    3. NM_001284219.1NP_001271148.1  cytosolic carboxypeptidase 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC135469, AK013688, BC060633, BC082335, BY597236
      UniProtKB/Swiss-Prot
      Q641K1
      Conserved Domains (1) summary
      cd06906
      Location:586863
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
    4. NM_001284221.1NP_001271150.1  cytosolic carboxypeptidase 1 isoform 4

      See identical proteins and their annotated locations for NP_001271150.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has a shorter 5' UTR and uses an alternate 3'-terminal exon, compared to variant 1. The encoded isoform (4) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK006181, BC082335
      Consensus CDS
      CCDS70470.1
      UniProtKB/Swiss-Prot
      Q641K1
      UniProtKB/TrEMBL
      Q8C1R2
      Related
      ENSMUSP00000130939.1, ENSMUST00000164215.7
      Conserved Domains (1) summary
      cd06906
      Location:8511128
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
    5. NM_023328.3NP_075817.2  cytosolic carboxypeptidase 1 isoform 1

      See identical proteins and their annotated locations for NP_075817.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK013688, AK015394, BC060633, BC082335, BY597236, CA528796
      Consensus CDS
      CCDS36686.1
      UniProtKB/Swiss-Prot
      Q641K1
      Related
      ENSMUSP00000022040.6, ENSMUST00000022040.13
      Conserved Domains (1) summary
      cd06906
      Location:8511128
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      59449534..59557366 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244557.2XP_011242859.1  cytosolic carboxypeptidase 1 isoform X5

      Conserved Domains (1) summary
      cd06906
      Location:8511110
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
    2. XM_011244555.2XP_011242857.1  cytosolic carboxypeptidase 1 isoform X2

      See identical proteins and their annotated locations for XP_011242857.1

      UniProtKB/Swiss-Prot
      Q641K1
      Conserved Domains (1) summary
      cd06906
      Location:8511128
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
    3. XM_006517339.2XP_006517402.1  cytosolic carboxypeptidase 1 isoform X3

      See identical proteins and their annotated locations for XP_006517402.1

      Conserved Domains (1) summary
      cd06906
      Location:8021079
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
    4. XM_011244556.2XP_011242858.1  cytosolic carboxypeptidase 1 isoform X3

      See identical proteins and their annotated locations for XP_011242858.1

      Conserved Domains (1) summary
      cd06906
      Location:8021079
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
    5. XM_006517335.2XP_006517398.1  cytosolic carboxypeptidase 1 isoform X1

      See identical proteins and their annotated locations for XP_006517398.1

      UniProtKB/Swiss-Prot
      Q641K1
      Conserved Domains (1) summary
      cd06906
      Location:8511128
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
    6. XM_006517342.3XP_006517405.1  cytosolic carboxypeptidase 1 isoform X6

      Conserved Domains (1) summary
      cd06906
      Location:7441021
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
    7. XM_006517340.3XP_006517403.1  cytosolic carboxypeptidase 1 isoform X4

      Conserved Domains (1) summary
      cd06906
      Location:7931070
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
    8. XM_006517336.3XP_006517399.1  cytosolic carboxypeptidase 1 isoform X1

      See identical proteins and their annotated locations for XP_006517399.1

      UniProtKB/Swiss-Prot
      Q641K1
      Conserved Domains (1) summary
      cd06906
      Location:8511128
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
    9. XM_006517338.3XP_006517401.1  cytosolic carboxypeptidase 1 isoform X1

      See identical proteins and their annotated locations for XP_006517401.1

      UniProtKB/Swiss-Prot
      Q641K1
      Conserved Domains (1) summary
      cd06906
      Location:8511128
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
    10. XM_006517337.3XP_006517400.1  cytosolic carboxypeptidase 1 isoform X1

      See identical proteins and their annotated locations for XP_006517400.1

      UniProtKB/Swiss-Prot
      Q641K1
      Conserved Domains (1) summary
      cd06906
      Location:8511128
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases

    RNA

    1. XR_001780797.1 RNA Sequence

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