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AGTPBP1 ATP/GTP binding carboxypeptidase 1 [ Homo sapiens (human) ]

Gene ID: 23287, updated on 27-Nov-2024

Summary

Official Symbol
AGTPBP1provided by HGNC
Official Full Name
ATP/GTP binding carboxypeptidase 1provided by HGNC
Primary source
HGNC:HGNC:17258
See related
Ensembl:ENSG00000135049 MIM:606830; AllianceGenome:HGNC:17258
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCP1; NNA1; CONDCA
Summary
NNA1 is a zinc carboxypeptidase that contains nuclear localization signals and an ATP/GTP-binding motif that was initially cloned from regenerating spinal cord neurons of the mouse.[supplied by OMIM, Jul 2002]
Expression
Broad expression in bone marrow (RPKM 7.2), brain (RPKM 4.8) and 23 other tissues See more
Orthologs
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Genomic context

See AGTPBP1 in Genome Data Viewer
Location:
9q21.33
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (85546539..85805483, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (97697026..97955976, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (88161454..88356944, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 33 pseudogene 1 Neighboring gene uncharacterized LOC101927603 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:88215278-88216090 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:88337736-88338412 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:88338413-88339088 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19988 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19987 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28513 Neighboring gene kinesin family member 27 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19989 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19990 Neighboring gene NANOG hESC enhancer GRCh37_chr9:88433900-88434401 Neighboring gene kinesin family member 27 pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:88494220-88494782 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:88513172-88514371 Neighboring gene PHB1 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA1035, DKFZp686M20191

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metallocarboxypeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metallocarboxypeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in C-terminal protein deglutamylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in C-terminal protein deglutamylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in adult walking behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in anterograde axonal transport of mitochondrion IEA
Inferred from Electronic Annotation
more info
 
involved_in central nervous system neuron development IEA
Inferred from Electronic Annotation
more info
 
involved_in cerebellar Purkinje cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in eye photoreceptor cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mitochondrion organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in neuromuscular process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in olfactory bulb development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein deglutamylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein side chain deglutamylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein side chain deglutamylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in retina development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
involved_in retrograde axonal transport of mitochondrion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytosolic carboxypeptidase 1
Names
ATP/GTP binding protein 1
carboxypeptidase-tubulin
nervous system nuclear protein induced by axotomy protein 1 homolog
protein deglutamylase CCP1
soluble carboxypeptidase
tubulinyl-Tyr carboxypeptidase
tyrosine carboxypeptidase
NP_001273644.1
NP_001273646.1
NP_001317630.1
NP_056054.2
XP_005251905.1
XP_011516720.1
XP_011516722.1
XP_011516723.1
XP_016870034.1
XP_047279042.1
XP_047279043.1
XP_047279044.1
XP_047279045.1
XP_047279046.1
XP_047279047.1
XP_047279048.1
XP_047279049.1
XP_047279050.1
XP_047279051.1
XP_047279052.1
XP_047279053.1
XP_047279054.1
XP_047279055.1
XP_047279056.1
XP_047279057.1
XP_054218489.1
XP_054218490.1
XP_054218491.1
XP_054218492.1
XP_054218493.1
XP_054218494.1
XP_054218495.1
XP_054218496.1
XP_054218497.1
XP_054218498.1
XP_054218499.1
XP_054218500.1
XP_054218501.1
XP_054218502.1
XP_054218503.1
XP_054218504.1
XP_054218505.1
XP_054218506.1
XP_054218507.1
XP_054218508.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286715.1NP_001273644.1  cytosolic carboxypeptidase 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AB028958, AK295774, CA449535
    Consensus CDS
    CCDS75854.1
    UniProtKB/TrEMBL
    J3KNS1
    Related
    ENSP00000338512.5, ENST00000337006.8
    Conserved Domains (1) summary
    cd06906
    Location:9111188
    M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
  2. NM_001286717.1NP_001273646.1  cytosolic carboxypeptidase 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
    Source sequence(s)
    AK295774, AL157882, AL451131, CA449535
    Consensus CDS
    CCDS69615.1
    UniProtKB/Swiss-Prot
    Q9UPW5
    Related
    ENSP00000487074.1, ENST00000628899.1
    Conserved Domains (1) summary
    cd06906
    Location:8711148
    M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
  3. NM_001330701.2NP_001317630.1  cytosolic carboxypeptidase 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AK295774, AL157882, AL833359, CA449535, CN354118, CN354120, DA326833, DB078109
    Consensus CDS
    CCDS83382.1
    UniProtKB/Swiss-Prot
    B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
    Related
    ENSP00000349592.3, ENST00000357081.8
  4. NM_015239.3NP_056054.2  cytosolic carboxypeptidase 1 isoform b

    See identical proteins and their annotated locations for NP_056054.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an additional exon in the 5' region and thus differs in its 5' UTR and initiates translation from an alternate start codon, and it also uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    BC060815, CA449535
    Consensus CDS
    CCDS6672.1
    Related
    ENSP00000365251.3, ENST00000376083.7
    Conserved Domains (1) summary
    cd06906
    Location:8191096
    M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    85546539..85805483 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423094.1XP_047279050.1  cytosolic carboxypeptidase 1 isoform X1

    UniProtKB/Swiss-Prot
    B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
  2. XM_047423090.1XP_047279046.1  cytosolic carboxypeptidase 1 isoform X1

    UniProtKB/Swiss-Prot
    B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
  3. XM_047423089.1XP_047279045.1  cytosolic carboxypeptidase 1 isoform X1

    UniProtKB/Swiss-Prot
    B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
  4. XM_047423088.1XP_047279044.1  cytosolic carboxypeptidase 1 isoform X1

    UniProtKB/Swiss-Prot
    B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
  5. XM_047423087.1XP_047279043.1  cytosolic carboxypeptidase 1 isoform X1

    UniProtKB/Swiss-Prot
    B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
  6. XM_047423086.1XP_047279042.1  cytosolic carboxypeptidase 1 isoform X1

    UniProtKB/Swiss-Prot
    B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
  7. XM_047423092.1XP_047279048.1  cytosolic carboxypeptidase 1 isoform X1

    UniProtKB/Swiss-Prot
    B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
  8. XM_047423093.1XP_047279049.1  cytosolic carboxypeptidase 1 isoform X1

    UniProtKB/Swiss-Prot
    B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
  9. XM_047423091.1XP_047279047.1  cytosolic carboxypeptidase 1 isoform X1

    UniProtKB/Swiss-Prot
    B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
  10. XM_005251848.3XP_005251905.1  cytosolic carboxypeptidase 1 isoform X1

    See identical proteins and their annotated locations for XP_005251905.1

    UniProtKB/Swiss-Prot
    B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
    Conserved Domains (1) summary
    cd06906
    Location:8591136
    M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
  11. XM_047423097.1XP_047279053.1  cytosolic carboxypeptidase 1 isoform X2

  12. XM_047423095.1XP_047279051.1  cytosolic carboxypeptidase 1 isoform X1

    UniProtKB/Swiss-Prot
    B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
  13. XM_047423096.1XP_047279052.1  cytosolic carboxypeptidase 1 isoform X2

  14. XM_047423100.1XP_047279056.1  cytosolic carboxypeptidase 1 isoform X6

  15. XM_047423099.1XP_047279055.1  cytosolic carboxypeptidase 1 isoform X5

  16. XM_011518420.3XP_011516722.1  cytosolic carboxypeptidase 1 isoform X8

    Conserved Domains (1) summary
    cd06906
    Location:504781
    M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
  17. XM_017014545.2XP_016870034.1  cytosolic carboxypeptidase 1 isoform X4

  18. XM_011518418.3XP_011516720.1  cytosolic carboxypeptidase 1 isoform X3

    Conserved Domains (1) summary
    cd06906
    Location:8591136
    M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
  19. XM_047423098.1XP_047279054.1  cytosolic carboxypeptidase 1 isoform X3

  20. XM_047423101.1XP_047279057.1  cytosolic carboxypeptidase 1 isoform X7

  21. XM_011518421.3XP_011516723.1  cytosolic carboxypeptidase 1 isoform X9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    97697026..97955976 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362522.1XP_054218497.1  cytosolic carboxypeptidase 1 isoform X1

    UniProtKB/Swiss-Prot
    B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
  2. XM_054362520.1XP_054218495.1  cytosolic carboxypeptidase 1 isoform X1

    UniProtKB/Swiss-Prot
    B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
  3. XM_054362521.1XP_054218496.1  cytosolic carboxypeptidase 1 isoform X1

    UniProtKB/Swiss-Prot
    B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
  4. XM_054362519.1XP_054218494.1  cytosolic carboxypeptidase 1 isoform X1

    UniProtKB/Swiss-Prot
    B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
  5. XM_054362518.1XP_054218493.1  cytosolic carboxypeptidase 1 isoform X1

    UniProtKB/Swiss-Prot
    B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
  6. XM_054362517.1XP_054218492.1  cytosolic carboxypeptidase 1 isoform X1

    UniProtKB/Swiss-Prot
    B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
  7. XM_054362516.1XP_054218491.1  cytosolic carboxypeptidase 1 isoform X1

    UniProtKB/Swiss-Prot
    B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
  8. XM_054362515.1XP_054218490.1  cytosolic carboxypeptidase 1 isoform X1

    UniProtKB/Swiss-Prot
    B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
  9. XM_054362514.1XP_054218489.1  cytosolic carboxypeptidase 1 isoform X1

    UniProtKB/Swiss-Prot
    B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
  10. XM_054362525.1XP_054218500.1  cytosolic carboxypeptidase 1 isoform X2

  11. XM_054362523.1XP_054218498.1  cytosolic carboxypeptidase 1 isoform X1

    UniProtKB/Swiss-Prot
    B4DIT6, B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1, Q9UPW5
  12. XM_054362524.1XP_054218499.1  cytosolic carboxypeptidase 1 isoform X2

  13. XM_054362530.1XP_054218505.1  cytosolic carboxypeptidase 1 isoform X6

  14. XM_054362529.1XP_054218504.1  cytosolic carboxypeptidase 1 isoform X5

  15. XM_054362532.1XP_054218507.1  cytosolic carboxypeptidase 1 isoform X8

  16. XM_054362528.1XP_054218503.1  cytosolic carboxypeptidase 1 isoform X4

  17. XM_054362526.1XP_054218501.1  cytosolic carboxypeptidase 1 isoform X3

  18. XM_054362527.1XP_054218502.1  cytosolic carboxypeptidase 1 isoform X3

  19. XM_054362531.1XP_054218506.1  cytosolic carboxypeptidase 1 isoform X7

  20. XM_054362533.1XP_054218508.1  cytosolic carboxypeptidase 1 isoform X9