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AGTPBP1 ATP/GTP binding protein 1 [ Homo sapiens (human) ]

Gene ID: 23287, updated on 5-Jul-2020

Summary

Official Symbol
AGTPBP1provided by HGNC
Official Full Name
ATP/GTP binding protein 1provided by HGNC
Primary source
HGNC:HGNC:17258
See related
Ensembl:ENSG00000135049 MIM:606830
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCP1; NNA1; CONDCA
Summary
NNA1 is a zinc carboxypeptidase that contains nuclear localization signals and an ATP/GTP-binding motif that was initially cloned from regenerating spinal cord neurons of the mouse.[supplied by OMIM, Jul 2002]
Expression
Broad expression in bone marrow (RPKM 7.2), brain (RPKM 4.8) and 23 other tissues See more
Orthologs

Genomic context

See AGTPBP1 in Genome Data Viewer
Location:
9q21.33
Exon count:
30
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (85546539..85742029, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (88161454..88356944, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 33 pseudogene 1 Neighboring gene uncharacterized LOC101927603 Neighboring gene kinesin family member 27 pseudogene Neighboring gene uncharacterized LOC102724057 Neighboring gene kinesin family member 27 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1035, DKFZp686M20191

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metallocarboxypeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
C-terminal protein deglutamylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
C-terminal protein deglutamylation ISS
Inferred from Sequence or Structural Similarity
more info
 
cerebellar Purkinje cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
eye photoreceptor cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion organization ISS
Inferred from Sequence or Structural Similarity
more info
 
neuromuscular process ISS
Inferred from Sequence or Structural Similarity
more info
 
olfactory bulb development ISS
Inferred from Sequence or Structural Similarity
more info
 
protein deglutamylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein side chain deglutamylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein side chain deglutamylation ISS
Inferred from Sequence or Structural Similarity
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytosolic carboxypeptidase 1
Names
carboxypeptidase-tubulin
nervous system nuclear protein induced by axotomy protein 1 homolog
soluble carboxypeptidase
tubulinyl-Tyr carboxypeptidase
tyrosine carboxypeptidase
NP_001273644.1
NP_001273646.1
NP_001317630.1
NP_056054.2
XP_005251905.1
XP_005251906.1
XP_011516720.1
XP_011516722.1
XP_011516723.1
XP_016870034.1
XP_016870035.1
XP_016870036.1
XP_016870037.1
XP_016870038.1
XP_016870039.1
XP_024303240.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286715.1NP_001273644.1  cytosolic carboxypeptidase 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AB028958, AK295774, CA449535
    Consensus CDS
    CCDS75854.1
    UniProtKB/Swiss-Prot
    Q9UPW5
    UniProtKB/TrEMBL
    J3KNS1
    Related
    ENSP00000338512.5, ENST00000337006.8
    Conserved Domains (1) summary
    cd06906
    Location:9111188
    M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
  2. NM_001286717.1NP_001273646.1  cytosolic carboxypeptidase 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
    Source sequence(s)
    AK295774, AL157882, AL451131, CA449535
    Consensus CDS
    CCDS69615.1
    UniProtKB/Swiss-Prot
    Q9UPW5
    Related
    ENSP00000487074.1, ENST00000628899.1
    Conserved Domains (1) summary
    cd06906
    Location:8711148
    M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
  3. NM_001330701.2NP_001317630.1  cytosolic carboxypeptidase 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AK295774, AL157882, AL833359, CA449535, CN354118, CN354120, DA326833, DB078109
    Consensus CDS
    CCDS83382.1
    UniProtKB/Swiss-Prot
    Q9UPW5
    Related
    ENSP00000349592.3, ENST00000357081.7
  4. NM_015239.2NP_056054.2  cytosolic carboxypeptidase 1 isoform b

    See identical proteins and their annotated locations for NP_056054.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an additional exon in the 5' region and thus differs in its 5' UTR and initiates translation from an alternate start codon, and it also uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    BC060815, CA449535, DC334722
    Consensus CDS
    CCDS6672.1
    UniProtKB/Swiss-Prot
    Q9UPW5
    UniProtKB/TrEMBL
    A0A024R288
    Related
    ENSP00000365251.3, ENST00000376083.7
    Conserved Domains (1) summary
    cd06906
    Location:8191096
    M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    85546539..85742029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251849.3XP_005251906.1  cytosolic carboxypeptidase 1 isoform X4

    Conserved Domains (1) summary
    cd06906
    Location:7411018
    M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
  2. XM_017014546.1XP_016870035.1  cytosolic carboxypeptidase 1 isoform X5

    UniProtKB/Swiss-Prot
    Q9UPW5
    Conserved Domains (1) summary
    cd06906
    Location:701978
    M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
  3. XM_024447472.1XP_024303240.1  cytosolic carboxypeptidase 1 isoform X7

    Conserved Domains (1) summary
    cd06906
    Location:594871
    M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
  4. XM_017014548.2XP_016870037.1  cytosolic carboxypeptidase 1 isoform X7

    Conserved Domains (1) summary
    cd06906
    Location:594871
    M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
  5. XM_005251848.2XP_005251905.1  cytosolic carboxypeptidase 1 isoform X1

    See identical proteins and their annotated locations for XP_005251905.1

    UniProtKB/Swiss-Prot
    Q9UPW5
    Conserved Domains (1) summary
    cd06906
    Location:8591136
    M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
  6. XM_011518420.2XP_011516722.1  cytosolic carboxypeptidase 1 isoform X9

    Conserved Domains (1) summary
    cd06906
    Location:504781
    M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
  7. XM_011518418.2XP_011516720.1  cytosolic carboxypeptidase 1 isoform X2

    Conserved Domains (1) summary
    cd06906
    Location:8591136
    M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
  8. XM_017014545.1XP_016870034.1  cytosolic carboxypeptidase 1 isoform X3

  9. XM_017014549.1XP_016870038.1  cytosolic carboxypeptidase 1 isoform X8

  10. XM_017014547.1XP_016870036.1  cytosolic carboxypeptidase 1 isoform X6

  11. XM_011518421.2XP_011516723.1  cytosolic carboxypeptidase 1 isoform X10

  12. XM_017014550.1XP_016870039.1  cytosolic carboxypeptidase 1 isoform X10

RNA

  1. XR_001746261.1 RNA Sequence

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