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    Rbm7 RNA binding motif protein 7 [ Mus musculus (house mouse) ]

    Gene ID: 67010, updated on 23-May-2018

    Summary

    Official Symbol
    Rbm7provided by MGI
    Official Full Name
    RNA binding motif protein 7provided by MGI
    Primary source
    MGI:MGI:1914260
    See related
    Ensembl:ENSMUSG00000042396 Vega:OTTMUSG00000063008
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AU041934; AW554393; 1200007M24Rik; 1500011D06Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 26.0), bladder adult (RPKM 18.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Rbm7 in Genome Data Viewer
    Location:
    9; 9 A5.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (48488697..48495330, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (48296814..48303410, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39335 Neighboring gene predicted gene, 39334 Neighboring gene RNA exonuclease 2 Neighboring gene predicted gene 5617 Neighboring gene nicotinamide N-methyltransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001326355.1NP_001313284.1  RNA-binding protein 7 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an alternate 3' splice site, compared to variant 1, which results in a frameshift and early stop codon. It encodes isoform 2 which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AA178228, AK151827, AK153504, BY087243
      UniProtKB/TrEMBL
      Q3U5M9
      Conserved Domains (2) summary
      COG0724
      Location:9101
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12592
      Location:983
      RRM_RBM7; RNA recognition motif in vertebrate RNA-binding protein 7 (RBM7)
    2. NM_001326356.1NP_001313285.1  RNA-binding protein 7 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an internal exon , compared to variant 1, which results in a frameshift and early stop codon. It encodes isoform 3 which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AA178228, AI853382, AK153504, BY087243
      UniProtKB/TrEMBL
      Q3U5M9
      Conserved Domains (2) summary
      COG0724
      Location:9101
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl17169
      Location:983
      RRM_SF; RNA recognition motif (RRM) superfamily
    3. NM_144948.5NP_659197.2  RNA-binding protein 7 isoform 1

      See identical proteins and their annotated locations for NP_659197.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
      Source sequence(s)
      AA178228, AK151056, BY087243
      Consensus CDS
      CCDS23155.1
      UniProtKB/Swiss-Prot
      Q9CQT2
      UniProtKB/TrEMBL
      Q14A95
      Related
      ENSMUSP00000126374.2, OTTMUSP00000079387, ENSMUST00000170000.3, OTTMUST00000153371
      Conserved Domains (2) summary
      COG0724
      Location:9101
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12592
      Location:983
      RRM_RBM7; RNA recognition motif in vertebrate RNA-binding protein 7 (RBM7)

    RNA

    1. NR_037589.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate exon in the 5' coding region, compared to variant 1, which results in a frameshift and early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record, however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for non-mediated mRNA decay (NMD).
      Source sequence(s)
      AA178228, AK153504, BY087243
      Related
      ENSMUST00000214923.1, OTTMUST00000153372
    2. NR_136937.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes an alternate exon in the 5' coding region, compared to variant 1, which results in a frameshift and early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record, however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for non-mediated mRNA decay (NMD).
      Source sequence(s)
      AA178228, AK005998, AK153504, BY087243

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      48488697..48495330 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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