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    Mindy3 MINDY lysine 48 deubiquitinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 66960, updated on 23-Jun-2021

    Summary

    Official Symbol
    Mindy3provided by MGI
    Official Full Name
    MINDY lysine 48 deubiquitinase 3provided by MGI
    Primary source
    MGI:MGI:1914210
    See related
    Ensembl:ENSMUSG00000026767
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam18; Fam188a; AI447827; AW111958; 1810041E18Rik; 2310047O13Rik; 5830410F13Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 3.8), CNS E14 (RPKM 3.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mindy3 in Genome Data Viewer
    Location:
    2; 2 A1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (12352074..12424298, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (12347263..12419489, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (12268891..12341087, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene karyopherin (importin) alpha 2 pseudogene Neighboring gene integrin alpha 8 Neighboring gene RIKEN cDNA E030013I19 gene Neighboring gene predicted gene 13321 Neighboring gene phosphotriesterase related Neighboring gene predicted gene, 52597

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Lys48-specific deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables Lys48-specific deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables thiol-dependent deubiquitinase ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase MINDY-3
    Names
    caspase recruitment domain containing protein
    deubiquitinating enzyme MINDY-3
    family with sequence similarity 188, member A
    protein FAM188A
    ubiquitin carboxyl-terminal hydrolase FAM188A
    NP_001342464.1
    NP_001342465.1
    NP_001342466.1
    NP_001342467.1
    NP_001342468.1
    NP_077147.2
    XP_006497585.1
    XP_006497586.1
    XP_006497587.1
    XP_006497588.1
    XP_006497589.1
    XP_006497592.1
    XP_030107834.1
    XP_036018396.1
    XP_036018397.1
    XP_036018398.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355535.1NP_001342464.1  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform b

      Status: VALIDATED

      Source sequence(s)
      AK143250, AL772342
      Related
      ENSMUST00000130225.7
      Conserved Domains (1) summary
      pfam13898
      Location:29314
      DUF4205; Domain of unknown function (DUF4205)
    2. NM_001355536.1NP_001342465.1  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform c precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variant 4, encodes isoform c.
      Source sequence(s)
      AL772342, AL845533
      Conserved Domains (1) summary
      pfam13898
      Location:6142
      DUF4205; Domain of unknown function (DUF4205)
    3. NM_001355537.1NP_001342466.1  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform c precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variant 3, encodes isoform c.
      Source sequence(s)
      AL772342, AL845533
      Conserved Domains (1) summary
      pfam13898
      Location:6142
      DUF4205; Domain of unknown function (DUF4205)
    4. NM_001355538.1NP_001342467.1  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform d precursor

      Status: VALIDATED

      Source sequence(s)
      AK075792, AL772342, AL845533
      Conserved Domains (1) summary
      pfam13898
      Location:6142
      DUF4205; Domain of unknown function (DUF4205)
    5. NM_001355539.1NP_001342468.1  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform e

      Status: VALIDATED

      Source sequence(s)
      AL845533, FO708924
      Conserved Domains (1) summary
      pfam13898
      Location:30103
      DUF4205; Domain of unknown function (DUF4205)
    6. NM_024185.4NP_077147.2  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform a

      See identical proteins and their annotated locations for NP_077147.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK009891, BY297479
      Consensus CDS
      CCDS15690.1
      UniProtKB/Swiss-Prot
      Q9CV28
      Related
      ENSMUSP00000028105.7, ENSMUST00000028105.13
      Conserved Domains (1) summary
      pfam13898
      Location:29314
      DUF4205; Domain of unknown function (DUF4205)

    RNA

    1. NR_149730.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772342, AL845533
      Related
      ENSMUST00000194533.6
    2. NR_149731.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772342, AL845533
    3. NR_149732.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772342, AL845533
      Related
      ENSMUST00000129489.8
    4. NR_149745.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772342, AL845533
      Related
      ENSMUST00000144645.8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      12352074..12424298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162503.1XP_036018396.1  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform X3

      Conserved Domains (1) summary
      pfam13898
      Location:29266
      DUF4205; Domain of unknown function (DUF4205)
    2. XM_006497523.5XP_006497586.1  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform X2

      Conserved Domains (1) summary
      pfam13898
      Location:29266
      DUF4205; Domain of unknown function (DUF4205)
    3. XM_006497522.5XP_006497585.1  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform X1

      Conserved Domains (1) summary
      pfam13898
      Location:29314
      DUF4205; Domain of unknown function (DUF4205)
    4. XM_030251974.2XP_030107834.1  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform X7

      Conserved Domains (1) summary
      pfam13898
      Location:6142
      DUF4205; Domain of unknown function (DUF4205)
    5. XM_036162504.1XP_036018397.1  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform X5

      Conserved Domains (1) summary
      pfam13898
      Location:54190
      DUF4205; Domain of unknown function (DUF4205)
    6. XM_006497524.3XP_006497587.1  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform X4

      Conserved Domains (1) summary
      pfam13898
      Location:29257
      DUF4205; Domain of unknown function (DUF4205)
    7. XM_006497529.3XP_006497592.1  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform X9

      Conserved Domains (1) summary
      pfam13898
      Location:30103
      DUF4205; Domain of unknown function (DUF4205)
    8. XM_006497525.3XP_006497588.1  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform X6

      Related
      ENSMUSP00000117457.3, ENSMUST00000124603.8
      Conserved Domains (1) summary
      pfam13898
      Location:80150
      DUF4205; Domain of unknown function (DUF4205)
    9. XM_036162505.1XP_036018398.1  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform X8

      Conserved Domains (1) summary
      pfam13898
      Location:6142
      DUF4205; Domain of unknown function (DUF4205)
    10. XM_006497526.5XP_006497589.1  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform X7

      See identical proteins and their annotated locations for XP_006497589.1

      Conserved Domains (1) summary
      pfam13898
      Location:6142
      DUF4205; Domain of unknown function (DUF4205)

    RNA

    1. XR_004940709.1 RNA Sequence

    2. XR_001783166.3 RNA Sequence

    3. XR_003953695.2 RNA Sequence

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