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MINDY3 MINDY lysine 48 deubiquitinase 3 [ Homo sapiens (human) ]

Gene ID: 80013, updated on 8-Nov-2022

Summary

Official Symbol
MINDY3provided by HGNC
Official Full Name
MINDY lysine 48 deubiquitinase 3provided by HGNC
Primary source
HGNC:HGNC:23578
See related
Ensembl:ENSG00000148481 MIM:611649; AllianceGenome:HGNC:23578
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CARP; DERP5; my042; MST126; FAM188A; MSTP126; C10orf97
Summary
The protein encoded by this gene contains a caspase-associated recruitment domain and may function in apoptosis. It has been identified as a tumor suppressor in lung and gastric cancers, and a polymorphism in the gene may be associated with gastric cancer risk. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Expression
Ubiquitous expression in bone marrow (RPKM 5.8), adrenal (RPKM 4.8) and 25 other tissues See more
Orthologs
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Genomic context

See MINDY3 in Genome Data Viewer
Location:
10p13
Exon count:
19
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (15778174..15860507, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (15796178..15878518, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (15820173..15902506, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene integrin subunit alpha 8 Neighboring gene Sharpr-MPRA regulatory region 12763 Neighboring gene Sharpr-MPRA regulatory region 7083 Neighboring gene uncharacterized LOC124902383 Neighboring gene Sharpr-MPRA regulatory region 8556 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13397

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables K48-linked deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables K48-linked deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein K48-linked deubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase MINDY-3
Names
CARD-containing protein
MINDY deubiquitinase 3
caspase recruitment domain containing pro-apoptotic protein
dermal papilla-derived protein 5
deubiquitinating enzyme MINDY-3
family with sequence similarity 188 member A
protein FAM188A
ubiquitin carboxyl-terminal hydrolase FAM188A
NP_001305259.1
NP_079224.1
XP_005252657.1
XP_006717571.1
XP_011517992.1
XP_011517993.1
XP_011517996.1
XP_016872160.1
XP_047281728.1
XP_047281729.1
XP_047281730.1
XP_047281731.1
XP_047281732.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318330.2NP_001305259.1  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon, and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform (a).
    Source sequence(s)
    AI573091, AK023459, BC020605, DA063140
    UniProtKB/Swiss-Prot
    Q9H8M7
    Related
    ENST00000477891.1
    Conserved Domains (1) summary
    pfam13898
    Location:6142
    DUF4205; Domain of unknown function (DUF4205)
  2. NM_024948.4NP_079224.1  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform a

    See identical proteins and their annotated locations for NP_079224.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AI573091, AK023459, DA063140
    Consensus CDS
    CCDS7110.1
    UniProtKB/Swiss-Prot
    Q9H3I4, Q9H8M7
    Related
    ENSP00000277632.3, ENST00000277632.8
    Conserved Domains (1) summary
    pfam13898
    Location:29315
    DUF4205; Domain of unknown function (DUF4205)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    15778174..15860507 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252600.3XP_005252657.1  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform X7

    See identical proteins and their annotated locations for XP_005252657.1

    UniProtKB/Swiss-Prot
    Q9H8M7
    Conserved Domains (1) summary
    pfam13898
    Location:6142
    DUF4205; Domain of unknown function (DUF4205)
  2. XM_006717508.3XP_006717571.1  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform X2

    See identical proteins and their annotated locations for XP_006717571.1

    Conserved Domains (1) summary
    pfam13898
    Location:29267
    DUF4205; Domain of unknown function (DUF4205)
  3. XM_011519694.2XP_011517996.1  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform X7

    See identical proteins and their annotated locations for XP_011517996.1

    UniProtKB/Swiss-Prot
    Q9H8M7
    Conserved Domains (1) summary
    pfam13898
    Location:6142
    DUF4205; Domain of unknown function (DUF4205)
  4. XM_047425774.1XP_047281730.1  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform X8

  5. XM_047425773.1XP_047281729.1  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform X6

  6. XM_017016671.2XP_016872160.1  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform X3

  7. XM_011519690.3XP_011517992.1  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform X1

    Conserved Domains (1) summary
    pfam13898
    Location:29315
    DUF4205; Domain of unknown function (DUF4205)
  8. XM_047425772.1XP_047281728.1  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform X5

  9. XM_011519691.3XP_011517993.1  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform X4

    Conserved Domains (1) summary
    pfam13898
    Location:29315
    DUF4205; Domain of unknown function (DUF4205)
  10. XM_047425776.1XP_047281732.1  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform X10

  11. XM_047425775.1XP_047281731.1  ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform X9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    15796178..15878518 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)