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    Dus2 dihydrouridine synthase 2 [ Mus musculus (house mouse) ]

    Gene ID: 66369, updated on 9-Sep-2018

    Summary

    Official Symbol
    Dus2provided by MGI
    Official Full Name
    dihydrouridine synthase 2provided by MGI
    Primary source
    MGI:MGI:1913619
    See related
    Ensembl:ENSMUSG00000031901 Vega:OTTMUSG00000031188
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dus2l; 2310016K04Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 5.7), cerebellum adult (RPKM 5.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dus2 in Genome Data Viewer
    Location:
    8; 8 D3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (106011478..106053840)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (108535407..108577719)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene dipeptidase 3 Neighboring gene dipeptidase 2 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 Neighboring gene nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 Neighboring gene RIKEN cDNA 1810019D21 gene Neighboring gene epithelial splicing regulatory protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    tRNA dihydrouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    tRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion HDA PubMed 

    General protein information

    Preferred Names
    tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
    NP_001288105.1
    NP_079794.1
    XP_006531341.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301176.1NP_001288105.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 2

      See identical proteins and their annotated locations for NP_001288105.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon and uses a downstream translation start codon compared to isoform 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AK009391, AK077451, BB596733
      UniProtKB/Swiss-Prot
      Q9D7B1
      Conserved Domains (2) summary
      cd00048
      Location:256320
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      cd02801
      Location:1139
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    2. NM_025518.4NP_079794.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 1

      See identical proteins and their annotated locations for NP_079794.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK009391, AK077451, BB596733
      Consensus CDS
      CCDS22627.1
      UniProtKB/Swiss-Prot
      Q9D7B1
      UniProtKB/TrEMBL
      Q14A90
      Related
      ENSMUSP00000034375.4, OTTMUSP00000040831, ENSMUST00000034375.10, OTTMUST00000077278
      Conserved Domains (3) summary
      COG0042
      Location:10314
      DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
      cd00048
      Location:369433
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      cd02801
      Location:13252
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      106011478..106053840
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531278.3XP_006531341.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X1

      See identical proteins and their annotated locations for XP_006531341.1

      UniProtKB/Swiss-Prot
      Q9D7B1
      UniProtKB/TrEMBL
      Q14A90
      Conserved Domains (3) summary
      COG0042
      Location:10314
      DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
      cd00048
      Location:369433
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      cd02801
      Location:13252
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
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