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DUS2 dihydrouridine synthase 2 [ Homo sapiens (human) ]

Gene ID: 54920, updated on 13-Feb-2019

Summary

Official Symbol
DUS2provided by HGNC
Official Full Name
dihydrouridine synthase 2provided by HGNC
Primary source
HGNC:HGNC:26014
See related
Ensembl:ENSG00000167264 MIM:609707
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SMM1; DUS2L; URLC8
Summary
This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
Expression
Broad expression in testis (RPKM 12.7), lymph node (RPKM 5.7) and 24 other tissues See more
Orthologs

Genomic context

See DUS2 in Genome Data Viewer
Location:
16q22.1
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (68022944..68079323)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (68056847..68113226)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 359, pseudogene Neighboring gene DPEP2 neighbor Neighboring gene DEAD-box helicase 28 Neighboring gene nuclear factor of activated T cells 3 Neighboring gene ribosomal protein S12 pseudogene 27 Neighboring gene microRNA 6773 Neighboring gene epithelial splicing regulatory protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • tRNA modification in the nucleus and cytosol, organism-specific biosystem (from REACTOME)
    tRNA modification in the nucleus and cytosol, organism-specific biosystemAt least 92 distinct tRNA nucleotide base modifications have been found. The modifications are made post-transcriptionally by a large group of disparate enzymes located in the nucleus, cytosol, and m...
  • tRNA processing, organism-specific biosystem (from REACTOME)
    tRNA processing, organism-specific biosystemGenes encoding transfer RNAs (tRNAs) are transcribed by RNA polymerase III in the nucleus and by mitochondrial RNA polymerase in the mitochondrion.In the nucleus transcription reactions produce precu...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: NFATC3

Homology

Clone Names

  • FLJ20399

Gene Ontology Provided by GOA

Function Evidence Code Pubs
double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
tRNA dihydrouridine synthase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of cell death IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
tRNA dihydrouridine synthesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
Names
SMM1 homolog
dihydrouridine synthase 2-like, SMM1 homolog
tRNA-dihydrouridine(20) synthase (NAD(P)(+))
up-regulated in lung cancer protein 8
NP_001258691.1
NP_001258692.1
NP_060273.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271762.1NP_001258691.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 1

    See identical proteins and their annotated locations for NP_001258691.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC130462, AK000406, BC006527, DC397403
    Consensus CDS
    CCDS10859.1
    UniProtKB/Swiss-Prot
    Q9NX74
    UniProtKB/TrEMBL
    A0A024R6Z7
    Related
    ENSP00000351769.6, ENST00000358896.10
    Conserved Domains (2) summary
    cd00048
    Location:369433
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    cd02801
    Location:13252
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
  2. NM_001271763.1NP_001258692.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons, resulting in the loss of an in-frame segment in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC130462, AK000406, AK296663, BC006527, DC397403
    Consensus CDS
    CCDS61970.1
    UniProtKB/Swiss-Prot
    Q9NX74
    UniProtKB/TrEMBL
    B4DKP8, E7EUN9
    Related
    ENSP00000409498.1, ENST00000432752.5
    Conserved Domains (3) summary
    COG0042
    Location:10279
    DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
    cd00048
    Location:334398
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    cd02801
    Location:13217
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
  3. NM_017803.5NP_060273.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 1

    See identical proteins and their annotated locations for NP_060273.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC130462, AK000406, BC006527
    Consensus CDS
    CCDS10859.1
    UniProtKB/Swiss-Prot
    Q9NX74
    UniProtKB/TrEMBL
    A0A024R6Z7
    Related
    ENSP00000455229.1, ENST00000565263.5
    Conserved Domains (2) summary
    cd00048
    Location:369433
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    cd02801
    Location:13252
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    68022944..68079323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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