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    Cks2 CDC28 protein kinase regulatory subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 66197, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cks2provided by MGI
    Official Full Name
    CDC28 protein kinase regulatory subunit 2provided by MGI
    Primary source
    MGI:MGI:1913447
    See related
    Ensembl:ENSMUSG00000062248
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CKSHS2; 1110038L14Rik
    Expression
    Broad expression in liver E14.5 (RPKM 122.1), liver E14 (RPKM 112.7) and 15 other tissues See more
    Orthologs

    Genomic context

    See Cks2 in Genome Data Viewer
    Location:
    13; 13 A5
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (51645232..51650662)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (51740601..51746031)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32834 Neighboring gene sphingosine-1-phosphate receptor 3 Neighboring gene src homology 2 domain-containing transforming protein C3 Neighboring gene SECIS binding protein 2 Neighboring gene sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Transgenic (1) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from BioSystems

    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cyclin-dependent protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cell cycle phase transition IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    cyclin-dependent kinases regulatory subunit 2
    Names
    CKS-2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025415.3NP_079691.1  cyclin-dependent kinases regulatory subunit 2

      See identical proteins and their annotated locations for NP_079691.1

      Status: VALIDATED

      Source sequence(s)
      AK166688, AU016270, DV661312
      Consensus CDS
      CCDS36664.1
      UniProtKB/Swiss-Prot
      P56390
      UniProtKB/TrEMBL
      Q545R9
      Related
      ENSMUSP00000075250.5, ENSMUST00000075853.5
      Conserved Domains (1) summary
      pfam01111
      Location:873
      CKS; Cyclin-dependent kinase regulatory subunit

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      51645232..51650662
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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