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CKS2 CDC28 protein kinase regulatory subunit 2 [ Homo sapiens (human) ]

Gene ID: 1164, updated on 9-Jan-2019

Summary

Official Symbol
CKS2provided by HGNC
Official Full Name
CDC28 protein kinase regulatory subunit 2provided by HGNC
Primary source
HGNC:HGNC:2000
See related
Ensembl:ENSG00000123975 MIM:116901
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CKSHS2
Summary
CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 88.8), bone marrow (RPKM 46.4) and 21 other tissues See more
Orthologs

Genomic context

See CKS2 in Genome Data Viewer
Location:
9q22.2
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (89311195..89316703)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (91926113..91931618)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene SHC adaptor protein 3 Neighboring gene uncharacterized LOC105376136 Neighboring gene microRNA 3153 Neighboring gene SECIS binding protein 2 Neighboring gene semaphorin 4D Neighboring gene proliferation-associated 2G4 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Small cell lung cancer, organism-specific biosystem (from KEGG)
    Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
  • Small cell lung cancer, conserved biosystem (from KEGG)
    Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
cyclin-dependent protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
meiosis I IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle phase transition IEA
Inferred from Electronic Annotation
more info
 
regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cyclin-dependent kinases regulatory subunit 2
Names
CDC28 protein kinase 2
CKS-2
CKS1(S. cerevisiae Cdc28/Cdc2 kinase subunit) homolog-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001827.3NP_001818.1  cyclin-dependent kinases regulatory subunit 2

    See identical proteins and their annotated locations for NP_001818.1

    Status: REVIEWED

    Source sequence(s)
    BM838320, BM841681, X54942
    Consensus CDS
    CCDS6682.1
    UniProtKB/Swiss-Prot
    P33552
    Related
    ENSP00000364976.3, ENST00000314355.6
    Conserved Domains (1) summary
    pfam01111
    Location:873
    CKS; Cyclin-dependent kinase regulatory subunit

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    89311195..89316703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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