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CKS2 CDC28 protein kinase regulatory subunit 2 [ Homo sapiens (human) ]

Gene ID: 1164, updated on 29-Mar-2023

Summary

Official Symbol
CKS2provided by HGNC
Official Full Name
CDC28 protein kinase regulatory subunit 2provided by HGNC
Primary source
HGNC:HGNC:2000
See related
Ensembl:ENSG00000123975 MIM:116901; AllianceGenome:HGNC:2000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CKSHS2
Summary
CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 88.8), bone marrow (RPKM 46.4) and 21 other tissues See more
Orthologs
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Genomic context

See CKS2 in Genome Data Viewer
Location:
9q22.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (89311195..89316703)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (101474973..101480477)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (91926110..91931618)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4063 Neighboring gene uncharacterized LOC105376136 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:91896966-91897484 Neighboring gene microRNA 3153 Neighboring gene SECIS binding protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:91978812-91979312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:91979313-91979813 Neighboring gene semaphorin 4D

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables cyclin-dependent protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in meiosis I IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic cell cycle phase transition IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cyclin-dependent kinases regulatory subunit 2
Names
CDC28 protein kinase 2
CKS-2
CKS1(S. cerevisiae Cdc28/Cdc2 kinase subunit) homolog-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001827.3NP_001818.1  cyclin-dependent kinases regulatory subunit 2

    See identical proteins and their annotated locations for NP_001818.1

    Status: REVIEWED

    Source sequence(s)
    BM838320, BM841681, X54942
    Consensus CDS
    CCDS6682.1
    UniProtKB/Swiss-Prot
    P33552, Q6LET5
    Related
    ENSP00000364976.3, ENST00000314355.7
    Conserved Domains (1) summary
    pfam01111
    Location:873
    CKS; Cyclin-dependent kinase regulatory subunit

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    89311195..89316703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    101474973..101480477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)