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Cks2 CDC28 protein kinase regulatory subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 66197, updated on 21-Apr-2024

Summary

Official Symbol
Cks2provided by MGI
Official Full Name
CDC28 protein kinase regulatory subunit 2provided by MGI
Primary source
MGI:MGI:1913447
See related
Ensembl:ENSMUSG00000062248 AllianceGenome:MGI:1913447
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CKSHS2; 1110038L14Rik
Summary
Enables chromatin binding activity. Acts upstream of or within several processes, including meiosis I; mitotic cell cycle phase transition; and regulation of transcription by RNA polymerase II. Predicted to be part of SCF ubiquitin ligase complex and cyclin-dependent protein kinase holoenzyme complex. Is expressed in branchial arch; cerebellum; and cerebral cortex. Orthologous to human CKS2 (CDC28 protein kinase regulatory subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14.5 (RPKM 122.1), liver E14 (RPKM 112.7) and 15 other tissues See more
Orthologs
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Genomic context

Location:
13 A5; 13 26.12 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (51799268..51804698)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (51645232..51650662)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene src homology 2 domain-containing transforming protein C3 Neighboring gene STARR-seq mESC enhancer starr_34513 Neighboring gene STARR-seq mESC enhancer starr_34514 Neighboring gene STARR-seq mESC enhancer starr_34516 Neighboring gene STARR-seq mESC enhancer starr_34519 Neighboring gene STARR-positive B cell enhancer ABC_E926 Neighboring gene predicted gene, 52049 Neighboring gene SECIS binding protein 2 Neighboring gene predicted gene, 22806 Neighboring gene sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D Neighboring gene STARR-seq mESC enhancer starr_34521 Neighboring gene STARR-positive B cell enhancer ABC_E11544 Neighboring gene STARR-positive B cell enhancer ABC_E4068 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:51862969-51863152 Neighboring gene predicted gene, 19281

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cyclin-dependent protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
cyclin-dependent kinases regulatory subunit 2
Names
CKS-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025415.3NP_079691.1  cyclin-dependent kinases regulatory subunit 2

    See identical proteins and their annotated locations for NP_079691.1

    Status: VALIDATED

    Source sequence(s)
    AK166688, AU016270, DV661312
    Consensus CDS
    CCDS36664.1
    UniProtKB/Swiss-Prot
    P56390
    UniProtKB/TrEMBL
    Q545R9
    Related
    ENSMUSP00000075250.6, ENSMUST00000075853.6
    Conserved Domains (1) summary
    pfam01111
    Location:873
    CKS; Cyclin-dependent kinase regulatory subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    51799268..51804698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)