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    UBE2Z ubiquitin conjugating enzyme E2 Z [ Homo sapiens (human) ]

    Gene ID: 65264, updated on 17-Jun-2024

    Summary

    Official Symbol
    UBE2Zprovided by HGNC
    Official Full Name
    ubiquitin conjugating enzyme E2 Zprovided by HGNC
    Primary source
    HGNC:HGNC:25847
    See related
    Ensembl:ENSG00000159202 MIM:611362; AllianceGenome:HGNC:25847
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    USE1; HOYS7
    Summary
    This gene encodes an enzyme which ubiquitinates proteins which participate in signaling pathways and apoptosis. [provided by RefSeq, Feb 2012]
    Expression
    Ubiquitous expression in thyroid (RPKM 33.3), brain (RPKM 25.6) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See UBE2Z in Genome Data Viewer
    Location:
    17q21.32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (48908407..48929056)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (49772123..49792776)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (46985769..47006418)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371814 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12343 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12345 Neighboring gene ATP synthase membrane subunit c locus 1 Neighboring gene ribosomal protein L37 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8662 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8663 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12347 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12348 Neighboring gene SNF8 subunit of ESCRT-II Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8664 Neighboring gene RNA, U1 small nuclear 42, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of ubiquitin-conjugating enzyme E2Z (UBE2Z) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ13855

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cysteine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables molecular adaptor activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 Z
    Names
    E2 ubiquitin-conjugating enzyme Z
    UBA6-specific enzyme E2
    uba6-specific E2 conjugating enzyme 1
    ubiquitin carrier protein Z
    ubiquitin conjugating enzyme E2Z
    ubiquitin-protein ligase Z
    NP_075567.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023079.5NP_075567.2  ubiquitin-conjugating enzyme E2 Z

      See identical proteins and their annotated locations for NP_075567.2

      Status: VALIDATED

      Source sequence(s)
      AC091133, AK122770, AL713782, BC015890
      Consensus CDS
      CCDS11540.2
      UniProtKB/Swiss-Prot
      A6N8M6, A6NC60, Q7L354, Q8TCM4, Q9H832, Q9H893
      Related
      ENSP00000354201.5, ENST00000360943.10
      Conserved Domains (1) summary
      cd00195
      Location:103221
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      48908407..48929056
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      49772123..49792776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)