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    SERINC1 serine incorporator 1 [ Homo sapiens (human) ]

    Gene ID: 57515, updated on 17-Jun-2024

    Summary

    Official Symbol
    SERINC1provided by HGNC
    Official Full Name
    serine incorporator 1provided by HGNC
    Primary source
    HGNC:HGNC:13464
    See related
    Ensembl:ENSG00000111897 MIM:614548; AllianceGenome:HGNC:13464
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TDE2; TMS2; TDE1L; TMS-2
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in several processes, including phosphatidylserine metabolic process; positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity; and positive regulation of serine C-palmitoyltransferase activity. Predicted to be located in endoplasmic reticulum membrane and plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in brain (RPKM 241.4), adrenal (RPKM 145.5) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SERINC1 in Genome Data Viewer
    Location:
    6q22.31
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (122443351..122471807, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (123631640..123660124, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (122764496..122792952, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RNA, U1 small nuclear 18, pseudogene Neighboring gene Sharpr-MPRA regulatory region 11815 Neighboring gene NANOG hESC enhancer GRCh37_chr6:122714378-122714996 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17514 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:122721093-122721592 Neighboring gene heat shock transcription factor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25021 Neighboring gene cAMP-dependent protein kinase inhibitor beta Neighboring gene uncharacterized LOC124901391 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:122884400-122884937 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:122884938-122885474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:122932197-122932842 Neighboring gene MPRA-validated peak6076 silencer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:123017072-123018271 Neighboring gene MPRA-validated peak6077 silencer Neighboring gene RNA, 7SL, cytoplasmic 564, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1253

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in membrane biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phosphatidylserine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of serine C-palmitoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sphingolipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    serine incorporator 1
    Names
    tumor differentially expressed protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020755.4NP_065806.1  serine incorporator 1

      See identical proteins and their annotated locations for NP_065806.1

      Status: VALIDATED

      Source sequence(s)
      AF087902, AY358429, BC033029
      Consensus CDS
      CCDS5125.1
      UniProtKB/Swiss-Prot
      B3KY69, E1P565, O75655, Q7Z2F5, Q8TAG1, Q9NRX5, Q9NTH8, Q9ULG7
      Related
      ENSP00000342962.3, ENST00000339697.5
      Conserved Domains (1) summary
      pfam03348
      Location:17451
      Serinc; Serine incorporator (Serinc)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      122443351..122471807 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      123631640..123660124 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)