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Serinc1 serine incorporator 1 [ Mus musculus (house mouse) ]

Gene ID: 56442, updated on 1-Mar-2024

Summary

Official Symbol
Serinc1provided by MGI
Official Full Name
serine incorporator 1provided by MGI
Primary source
MGI:MGI:1926228
See related
Ensembl:ENSMUSG00000019877 AllianceGenome:MGI:1926228
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tde2; Tms2; TMS-2; Tde1l; AIGP-2; mKIAA1253; 1500011D18Rik
Summary
Predicted to enable enzyme binding activity and protein-macromolecule adaptor activity. Predicted to be involved in several processes, including phosphatidylserine metabolic process; positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity; and positive regulation of serine C-palmitoyltransferase activity. Predicted to act upstream of or within phospholipid biosynthetic process. Located in plasma membrane. Is expressed in ganglia and small intestine. Orthologous to human SERINC1 (serine incorporator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 153.7), frontal lobe adult (RPKM 152.5) and 24 other tissues See more
Orthologs
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Genomic context

See Serinc1 in Genome Data Viewer
Location:
10 B4; 10 29.19 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (57391870..57408573, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (57515774..57532529, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene interleukin 25 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr10:57160658-57160959 Neighboring gene STARR-positive B cell enhancer mm9_chr10:57161280-57161581 Neighboring gene STARR-positive B cell enhancer mm9_chr10:57183198-57183499 Neighboring gene RIKEN cDNA 4930467K11 gene Neighboring gene STARR-positive B cell enhancer ABC_E10607 Neighboring gene heat shock factor 2 Neighboring gene STARR-positive B cell enhancer mm9_chr10:57250127-57250428 Neighboring gene STARR-seq mESC enhancer starr_26749 Neighboring gene STARR-seq mESC enhancer starr_26750 Neighboring gene ribosomal protein L48, pseudogene 1 Neighboring gene protein kinase inhibitor beta, cAMP dependent, testis specific Neighboring gene predicted gene, 18253

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transposon induced (1)  1 citation
  • Gene trapped (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane biogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylserine metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sphingolipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine incorporator 1
Names
axotomy induced glycoprotein 2
axotomy-induced glyco/Golgi protein 2
membrane protein TMS-2
tumor differentially expressed 1, like
tumor differentially expressed 2
tumor differentially expressed protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019760.4NP_062734.1  serine incorporator 1

    See identical proteins and their annotated locations for NP_062734.1

    Status: VALIDATED

    Source sequence(s)
    AC153823
    Consensus CDS
    CCDS23853.1
    UniProtKB/Swiss-Prot
    Q3UZ93, Q9QZI8
    UniProtKB/TrEMBL
    A9CLV6
    Related
    ENSMUSP00000020027.5, ENSMUST00000020027.11
    Conserved Domains (1) summary
    pfam03348
    Location:17451
    Serinc; Serine incorporator (Serinc)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    57391870..57408573 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)