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    SPC25 SPC25 component of NDC80 kinetochore complex [ Homo sapiens (human) ]

    Gene ID: 57405, updated on 9-Jun-2024

    Summary

    Official Symbol
    SPC25provided by HGNC
    Official Full Name
    SPC25 component of NDC80 kinetochore complexprovided by HGNC
    Primary source
    HGNC:HGNC:24031
    See related
    Ensembl:ENSG00000152253 MIM:609395; AllianceGenome:HGNC:24031
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AD024; SPBC25; hSpc25
    Summary
    This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in lymph node (RPKM 4.1), bone marrow (RPKM 2.8) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SPC25 in Genome Data Viewer
    Location:
    2q24.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (168861521..168890430, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (169319011..169364874, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (169727401..169746940, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ceramide synthase 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:169471049-169471548 Neighboring gene RNA, U6 small nuclear 766, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16736 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:169592586-169593086 Neighboring gene CERS6 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 4310 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:169658591-169659090 Neighboring gene nitric oxide synthase trafficking Neighboring gene uncharacterized LOC124907904 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:169764453-169765248 Neighboring gene glucose-6-phosphatase catalytic subunit 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC22228

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromosome segregation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in mitotic spindle assembly checkpoint signaling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Ndc80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Ndc80 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Ndc80 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in kinetochore NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    kinetochore protein Spc25
    Names
    2600017H08Rik
    SPC25, NDC80 kinetochore complex component, homolog
    spindle pole body component 25 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020675.4NP_065726.1  kinetochore protein Spc25

      See identical proteins and their annotated locations for NP_065726.1

      Status: REVIEWED

      Source sequence(s)
      AC069137
      Consensus CDS
      CCDS2229.1
      UniProtKB/Swiss-Prot
      A8K4X8, D3DPC0, Q9HBM1
      Related
      ENSP00000282074.2, ENST00000282074.7
      Conserved Domains (2) summary
      pfam10186
      Location:26127
      Atg14; Vacuolar sorting 38 and autophagy-related subunit 14
      pfam08234
      Location:149218
      Spindle_Spc25; Chromosome segregation protein Spc25

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      168861521..168890430 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011511516.3XP_011509818.1  kinetochore protein Spc25 isoform X1

      See identical proteins and their annotated locations for XP_011509818.1

      Conserved Domains (1) summary
      pfam08234
      Location:149183
      Spindle_Spc25; Chromosome segregation protein Spc25

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003315909.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      31163..77057 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329484.1XP_054185459.1  kinetochore protein Spc25 isoform X1

    2. XM_054329483.1XP_054185458.1  kinetochore protein Spc25 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      169319011..169364874 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343128.1XP_054199103.1  kinetochore protein Spc25 isoform X1

    2. XM_054343127.1XP_054199102.1  kinetochore protein Spc25 isoform X3