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    CHRNA10 cholinergic receptor nicotinic alpha 10 subunit [ Homo sapiens (human) ]

    Gene ID: 57053, updated on 11-Apr-2024

    Summary

    Official Symbol
    CHRNA10provided by HGNC
    Official Full Name
    cholinergic receptor nicotinic alpha 10 subunitprovided by HGNC
    Primary source
    HGNC:HGNC:13800
    See related
    Ensembl:ENSG00000129749 MIM:606372; AllianceGenome:HGNC:13800
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable acetylcholine-gated cation-selective channel activity. Acts upstream of or within positive regulation of cytosolic calcium ion concentration. Predicted to be located in membrane. Predicted to be active in cholinergic synapse and neuron projection. Predicted to be integral component of postsynaptic specialization membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See CHRNA10 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (3665587..3671384, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (3730960..3736757, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (3686817..3692614, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:3662929-3663642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3081 Neighboring gene ADP-ribosyltransferase 5 Neighboring gene ADP-ribosyltransferase 1 Neighboring gene nucleoporin 98 and 96 precursor Neighboring gene small nucleolar RNA U13 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:3717665-3717885 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:3723311-3723810 Neighboring gene RNA, U6 small nuclear 1143, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables acetylcholine-gated monoatomic cation-selective channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cholinergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic specialization membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transmembrane transporter complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    neuronal acetylcholine receptor subunit alpha-10
    Names
    NACHR alpha-10
    acetylcholine receptor, nicotinic, alpha 10 (neuronal)
    cholinergic receptor, nicotinic alpha 10
    cholinergic receptor, nicotinic, alpha 10 (neuronal)
    cholinergic receptor, nicotinic, alpha polypeptide 10
    nicotinic acetylcholine receptor subunit alpha-10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303034.2NP_001289963.1  neuronal acetylcholine receptor subunit alpha-10 isoform b

      See identical proteins and their annotated locations for NP_001289963.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site at an internal exon compared to variant 1. This difference results in translation initiation at a downstream in-frame start site through ribosomal re-initiation or leaky scanning. The encoded isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC060812, AF199235, BC143303
      UniProtKB/Swiss-Prot
      Q9GZZ6
      Conserved Domains (2) summary
      pfam02931
      Location:129
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:37228
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    2. NM_001303035.2NP_001289964.1  neuronal acetylcholine receptor subunit alpha-10 isoform b

      See identical proteins and their annotated locations for NP_001289964.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses two alternate splice sites at an internal exon compared to variant 1. These differences result in translation initiation at a downstream in-frame start site through ribosomal re-initiation or leaky scanning. The encoded isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC060812, AF199235, BC136250
      UniProtKB/Swiss-Prot
      Q9GZZ6
      UniProtKB/TrEMBL
      C4IXS7
      Conserved Domains (2) summary
      pfam02931
      Location:129
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:37228
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    3. NM_020402.4NP_065135.2  neuronal acetylcholine receptor subunit alpha-10 isoform a precursor

      See identical proteins and their annotated locations for NP_065135.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC060812, AF199235
      Consensus CDS
      CCDS7745.1
      UniProtKB/Swiss-Prot
      Q9GZZ6
      UniProtKB/TrEMBL
      C4IXS7
      Related
      ENSP00000250699.2, ENST00000250699.2
      Conserved Domains (3) summary
      TIGR00860
      Location:31442
      LIC; Cation transporter family protein
      pfam02931
      Location:32235
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:243434
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      3665587..3671384 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      3730960..3736757 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)