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    Orc6 origin recognition complex, subunit 6 [ Mus musculus (house mouse) ]

    Gene ID: 56452, updated on 31-Jan-2019

    Summary

    Official Symbol
    Orc6provided by MGI
    Official Full Name
    origin recognition complex, subunit 6provided by MGI
    Primary source
    MGI:MGI:1929285
    See related
    Ensembl:ENSMUSG00000031697
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Orc6l; 6720420I10Rik
    Expression
    Broad expression in liver E14 (RPKM 33.8), CNS E11.5 (RPKM 28.8) and 21 other tissues See more
    Orthologs

    Genomic context

    See Orc6 in Genome Data Viewer
    Location:
    8; 8 C3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (85299632..85308279)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (87823531..87832178)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene olfactory receptor 371 Neighboring gene VPS35 retromer complex component Neighboring gene myosin light chain kinase 3 Neighboring gene RIKEN cDNA 4921524J17 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC91038

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-dependent DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear origin of replication recognition complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    origin recognition complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    origin recognition complex subunit 6

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163791.1NP_001157263.1  origin recognition complex subunit 6 isoform b

      See identical proteins and their annotated locations for NP_001157263.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AC134854, AK078405, AK163256, BF661105, BP771997
      Consensus CDS
      CCDS52623.1
      UniProtKB/TrEMBL
      Q3TQX1
      Related
      ENSMUSP00000126925.1, ENSMUST00000170141.2
      Conserved Domains (2) summary
      cd11583
      Location:18110
      Orc6_mid; Middle domain of the origin recognition complex subunit 6
      cd16075
      Location:135183
      ORC6_CTD; C-terminal domain of the eukaryotic origin recognition complex subunit ORC6
    2. NM_019716.2NP_062690.2  origin recognition complex subunit 6 isoform a

      See identical proteins and their annotated locations for NP_062690.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC134854, AK078405, AK163256, BC080739, BF661105, BP771997
      Consensus CDS
      CCDS22497.1
      UniProtKB/TrEMBL
      Q3TQX1, Q66JV6
      Related
      ENSMUSP00000034132.5, ENSMUST00000034132.12
      Conserved Domains (3) summary
      cd11583
      Location:94186
      Orc6_mid; Middle domain of the origin recognition complex subunit 6
      pfam05460
      Location:694
      ORC6; Origin recognition complex subunit 6 (ORC6)
      cd16075
      Location:211259
      ORC6_CTD; C-terminal domain of the eukaryotic origin recognition complex subunit ORC6

    RNA

    1. NR_028268.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC134854, AK078405, AK163256, BC080739, BF661105, BP771997

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      85299632..85308279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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