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ORC6 origin recognition complex subunit 6 [ Homo sapiens (human) ]

Gene ID: 23594, updated on 20-Dec-2019

Summary

Official Symbol
ORC6provided by HGNC
Official Full Name
origin recognition complex subunit 6provided by HGNC
Primary source
HGNC:HGNC:17151
See related
Ensembl:ENSG00000091651 MIM:607213
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ORC6L
Summary
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]
Expression
Broad expression in testis (RPKM 6.8), bone marrow (RPKM 5.0) and 16 other tissues See more
Orthologs

Genomic context

See ORC6 in Genome Data Viewer
Location:
16q11.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (46689656..46698394)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (46723558..46732306)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RAB43 pseudogene 1 Neighboring gene VPS35 retromer complex component Neighboring gene myosin light chain kinase 3 Neighboring gene nuclear factor, erythroid 2 like 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA replication TAS
Traceable Author Statement
more info
 
DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
negative regulation of cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
fibrillar center IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nuclear origin of replication recognition complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
origin recognition complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
origin recognition complex subunit 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028241.1 RefSeqGene

    Range
    5014..13749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014321.4NP_055136.1  origin recognition complex subunit 6

    See identical proteins and their annotated locations for NP_055136.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    BC050725, BC063565
    Consensus CDS
    CCDS10722.1
    UniProtKB/Swiss-Prot
    Q9Y5N6
    UniProtKB/TrEMBL
    A0A024R6R3
    Related
    ENSP00000219097.2, ENST00000219097.7
    Conserved Domains (3) summary
    cd11583
    Location:94186
    Orc6_mid; Middle domain of the origin recognition complex subunit 6
    cd16075
    Location:199249
    ORC6_CTD; C-terminal domain of the eukaryotic origin recognition complex subunit ORC6
    pfam05460
    Location:694
    ORC6; Origin recognition complex subunit 6 (ORC6)

RNA

  1. NR_037620.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most [supported/expected] translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC007225, BC050725, BC063565, BG822640

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    46689656..46698394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522978.3XP_011521280.1  origin recognition complex subunit 6 isoform X1

    Conserved Domains (2) summary
    pfam05460
    Location:694
    ORC6; Origin recognition complex subunit 6 (ORC6)
    cl21687
    Location:94150
    Orc6_mid; Middle domain of the origin recognition complex subunit 6
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