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    Ncoa6 nuclear receptor coactivator 6 [ Mus musculus (house mouse) ]

    Gene ID: 56406, updated on 27-Feb-2024

    Summary

    Official Symbol
    Ncoa6provided by MGI
    Official Full Name
    nuclear receptor coactivator 6provided by MGI
    Primary source
    MGI:MGI:1929915
    See related
    Ensembl:ENSMUSG00000038369 AllianceGenome:MGI:1929915
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NRC; AIB3; ASC2; PRIP; ASC-2; Ncoa7; RAP250; mKIAA0181
    Summary
    Enables chromatin binding activity and transcription coactivator activity. Acts upstream of or within animal organ development; histone H3-K4 trimethylation; and positive regulation of transcription, DNA-templated. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in breast cancer; colon cancer; and lung cancer. Orthologous to human NCOA6 (nuclear receptor coactivator 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 15.8), whole brain E14.5 (RPKM 15.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ncoa6 in Genome Data Viewer
    Location:
    2 H1; 2 77.26 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155232585..155315741, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (155390656..155473911, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class U Neighboring gene STARR-positive B cell enhancer ABC_E6004 Neighboring gene microRNA 695 Neighboring gene STARR-positive B cell enhancer ABC_E11173 Neighboring gene STARR-positive B cell enhancer ABC_E4511 Neighboring gene transformation related protein 53 inducible nuclear protein 2 Neighboring gene ribosomal protein L8 pseudogene Neighboring gene carnitine deficiency-associated gene expressed in ventricle 3 pseudogene Neighboring gene cytochrome c, somatic pseudogene Neighboring gene gamma-glutamyltransferase 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (10)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC90663

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin-protein adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone methyltransferase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear glucocorticoid receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear retinoic acid receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear retinoid X receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear vitamin D receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peroxisome proliferator activated receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of MLL3/4 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of histone methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear receptor coactivator 6
    Names
    PPAR interacting protein PRIP
    PPAR-interacting protein
    activating signal cointegrator 2
    amplified in breast cancer protein 3
    cancer-amplified transcriptional coactivator ASC-2
    nuclear receptor coactivator RAP250
    nuclear receptor-activating protein 250
    nuclear receptor-activating protein, 250 kDa
    peroxisome proliferator-activated receptor interacting protein,PRIP
    peroxisome proliferator-activated receptor-interacting protein
    thyroid hormone receptor binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242558.2NP_001229487.1  nuclear receptor coactivator 6 isoform 2

      See identical proteins and their annotated locations for NP_001229487.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2, also known as Ncoa6-beta) missing an internal protein segment compared to isoform 1.
      Source sequence(s)
      AL844852, AL845325
      UniProtKB/TrEMBL
      F6M2J9, F6M2K1
      Conserved Domains (3) summary
      PHA03247
      Location:145550
      PHA03247; large tegument protein UL36; Provisional
      pfam09606
      Location:471864
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam13820
      Location:48189
      Nucleic_acid_bd; Putative nucleic acid-binding region
    2. NM_001406325.1NP_001393254.1  nuclear receptor coactivator 6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL844852, AL845325
      UniProtKB/Swiss-Prot
      Q9JL19, Q9JLT9
      UniProtKB/TrEMBL
      Q5XJV5
      Related
      ENSMUSP00000045386.6, ENSMUST00000043126.12
    3. NM_001406326.1NP_001393255.1  nuclear receptor coactivator 6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL844852, AL845325
      UniProtKB/Swiss-Prot
      Q9JL19, Q9JLT9
      UniProtKB/TrEMBL
      Q5XJV5
    4. NM_019825.4NP_062799.2  nuclear receptor coactivator 6 isoform 1

      See identical proteins and their annotated locations for NP_062799.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1, also known as Ncoa6-alpha)
      Source sequence(s)
      AL844852, AL845325
      Consensus CDS
      CCDS38295.1
      UniProtKB/Swiss-Prot
      Q9JL19, Q9JLT9
      UniProtKB/TrEMBL
      Q5XJV5
      Related
      ENSMUSP00000105295.2, ENSMUST00000109670.8
      Conserved Domains (4) summary
      PHA03247
      Location:11731810
      PHA03247; large tegument protein UL36; Provisional
      pfam09606
      Location:471864
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam08580
      Location:10821326
      KAR9; Yeast cortical protein KAR9
      pfam13820
      Location:48189
      Nucleic_acid_bd; Putative nucleic acid-binding region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      155232585..155315741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)