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    Morf4l2 mortality factor 4 like 2 [ Mus musculus (house mouse) ]

    Gene ID: 56397, updated on 5-Mar-2024

    Summary

    Official Symbol
    Morf4l2provided by MGI
    Official Full Name
    mortality factor 4 like 2provided by MGI
    Primary source
    MGI:MGI:1927167
    See related
    Ensembl:ENSMUSG00000031422 AllianceGenome:MGI:1927167
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mrgx; Sid393p; mKIAA0026; 2410017O14Rik
    Summary
    Predicted to be involved in heterochromatin assembly and histone modification. Predicted to act upstream of or within DNA repair and regulation of growth. Predicted to be located in nucleolus; nucleoplasm; and plasma membrane. Predicted to be part of NuA4 histone acetyltransferase complex. Is expressed in genitourinary system and retina. Orthologous to human MORF4L2 (mortality factor 4 like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in placenta adult (RPKM 441.2), CNS E11.5 (RPKM 149.5) and 12 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    X F1; X 59.1 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (135633691..135644435, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (136732942..136743686, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene acyl-protein thioesterase 1 pseudogene Neighboring gene predicted gene, 39536 Neighboring gene transcription elongation factor A (SII)-like 1 Neighboring gene STARR-seq mESC enhancer starr_47978 Neighboring gene STARR-positive B cell enhancer ABC_E3262 Neighboring gene STARR-positive B cell enhancer ABC_E11056 Neighboring gene cDNA sequence BC065397 Neighboring gene glycine receptor, alpha 4 subunit Neighboring gene predicted gene, 54085 Neighboring gene STARR-seq mESC enhancer starr_47979 Neighboring gene proteolipid protein (myelin) 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mortality factor 4-like protein 2
    Names
    MORF-related gene X protein
    sid 393
    transcription factor-like protein Mrgx

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168225.1NP_001161697.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001161697.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein.
      Source sequence(s)
      AK160012, AL671887, BC075653
      Consensus CDS
      CCDS30422.1
      UniProtKB/Swiss-Prot
      A2AEB2, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2, Q9R0Q4
      UniProtKB/TrEMBL
      Q3TME1, Q3U6G8
      Related
      ENSMUSP00000126363.2, ENSMUST00000166930.8
      Conserved Domains (2) summary
      PLN02967
      Location:1150
      PLN02967; kinase
      pfam05712
      Location:110276
      MRG
    2. NM_001168226.1NP_001161698.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001161698.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein.
      Source sequence(s)
      AK160012, AL671887, BC075653, BY141735
      Consensus CDS
      CCDS30422.1
      UniProtKB/Swiss-Prot
      A2AEB2, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2, Q9R0Q4
      UniProtKB/TrEMBL
      Q3TME1, Q3U6G8
      Related
      ENSMUSP00000108722.4, ENSMUST00000080411.13
      Conserved Domains (2) summary
      PLN02967
      Location:1150
      PLN02967; kinase
      pfam05712
      Location:110276
      MRG
    3. NM_001168227.1NP_001161699.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001161699.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein.
      Source sequence(s)
      AK160012, AL671887, BC075653
      Consensus CDS
      CCDS30422.1
      UniProtKB/Swiss-Prot
      A2AEB2, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2, Q9R0Q4
      UniProtKB/TrEMBL
      Q3TME1, Q3U6G8
      Related
      ENSMUSP00000129774.2, ENSMUST00000164609.8
      Conserved Domains (2) summary
      PLN02967
      Location:1150
      PLN02967; kinase
      pfam05712
      Location:110276
      MRG
    4. NM_001168228.1NP_001161700.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001161700.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein.
      Source sequence(s)
      AK161610, AL671887, BC075653
      Consensus CDS
      CCDS30422.1
      UniProtKB/Swiss-Prot
      A2AEB2, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2, Q9R0Q4
      UniProtKB/TrEMBL
      Q3TME1, Q3U6G8
      Related
      ENSMUSP00000108720.2, ENSMUST00000113097.8
      Conserved Domains (2) summary
      PLN02967
      Location:1150
      PLN02967; kinase
      pfam05712
      Location:110276
      MRG
    5. NM_001168229.1NP_001161701.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001161701.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein.
      Source sequence(s)
      AK160012, AL671887, BC075653, BY141735
      Consensus CDS
      CCDS30422.1
      UniProtKB/Swiss-Prot
      A2AEB2, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2, Q9R0Q4
      UniProtKB/TrEMBL
      Q3TME1, Q3U6G8
      Related
      ENSMUSP00000132643.2, ENSMUST00000169418.8
      Conserved Domains (2) summary
      PLN02967
      Location:1150
      PLN02967; kinase
      pfam05712
      Location:110276
      MRG
    6. NM_001168230.1NP_001161702.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001161702.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein.
      Source sequence(s)
      AK161610, AL671887, BC075653
      Consensus CDS
      CCDS30422.1
      UniProtKB/Swiss-Prot
      A2AEB2, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2, Q9R0Q4
      UniProtKB/TrEMBL
      Q3TME1, Q3U6G8
      Related
      ENSMUSP00000131909.2, ENSMUST00000166478.8
      Conserved Domains (2) summary
      PLN02967
      Location:1150
      PLN02967; kinase
      pfam05712
      Location:110276
      MRG
    7. NM_019768.4NP_062742.4  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_062742.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 through 7 encode the same protein.
      Source sequence(s)
      AK161610, BC075653
      Consensus CDS
      CCDS30422.1
      UniProtKB/Swiss-Prot
      A2AEB2, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2, Q9R0Q4
      UniProtKB/TrEMBL
      Q3TME1, Q3U6G8
      Related
      ENSMUSP00000033797.7, ENSMUST00000033797.13
      Conserved Domains (2) summary
      PLN02967
      Location:1150
      PLN02967; kinase
      pfam05712
      Location:110276
      MRG

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      135633691..135644435 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528584.3XP_006528647.1  mortality factor 4-like protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006528647.1

      UniProtKB/Swiss-Prot
      A2AEB2, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2, Q9R0Q4
      UniProtKB/TrEMBL
      Q3TME1, Q3U6G8
      Conserved Domains (2) summary
      PLN02967
      Location:1150
      PLN02967; kinase
      pfam05712
      Location:110276
      MRG