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MORF4L2 mortality factor 4 like 2 [ Homo sapiens (human) ]

Gene ID: 9643, updated on 22-May-2022

Summary

Official Symbol
MORF4L2provided by HGNC
Official Full Name
mortality factor 4 like 2provided by HGNC
Primary source
HGNC:HGNC:16849
See related
Ensembl:ENSG00000123562 MIM:300409; AllianceGenome:HGNC:16849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRGX; MORFL2
Summary
Predicted to be involved in heterochromatin assembly and histone modification. Predicted to act upstream of or within positive regulation of striated muscle cell differentiation and positive regulation of transcription by RNA polymerase II. Located in nucleolus; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 110.4), endometrium (RPKM 100.8) and 25 other tissues See more
Orthologs
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Genomic context

See MORF4L2 in Genome Data Viewer
Location:
Xq22.2
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (103675498..103688047, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (102122473..102135021, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (102930426..102942975, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 5968 Neighboring gene transcription elongation factor A like 1 Neighboring gene CNEP1R1 pseudogene 1 Neighboring gene MORF4L2 antisense RNA 1 Neighboring gene glycine receptor alpha 4 (pseudogene) Neighboring gene transmembrane protein 31 Neighboring gene RAB9B, member RAS oncogene family Neighboring gene proteolipid protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0026

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in histone H2A acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone H2A acetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone H4 acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone H4 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone acetylation IC
Inferred by Curator
more info
PubMed 
involved_in histone deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of striated muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription, DNA-templated IC
Inferred by Curator
more info
PubMed 
involved_in regulation of apoptotic process IC
Inferred by Curator
more info
PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of double-strand break repair IC
Inferred by Curator
more info
PubMed 
involved_in regulation of growth IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of NuA4 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of nucleosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
mortality factor 4-like protein 2
Names
MORF-related gene X protein
MSL3-2 protein
protein MSL3-2
transcription factor-like protein MRGX

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142418.2NP_001135890.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135890.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    BC093013, DC419967
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    Q15014
    Conserved Domains (1) summary
    pfam05712
    Location:110276
    MRG
  2. NM_001142419.2NP_001135891.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135891.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AL049610, BC093013, DA268606
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    Q15014
    Related
    ENSP00000415476.2, ENST00000433176.6
    Conserved Domains (1) summary
    pfam05712
    Location:110276
    MRG
  3. NM_001142420.2NP_001135892.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135892.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AL049610, BC093013
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    Q15014
    Conserved Domains (1) summary
    pfam05712
    Location:110276
    MRG
  4. NM_001142421.2NP_001135893.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135893.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AL049610, BC093013, DA268606
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    Q15014
    Related
    ENSP00000353643.1, ENST00000360458.5
    Conserved Domains (1) summary
    pfam05712
    Location:110276
    MRG
  5. NM_001142422.2NP_001135894.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135894.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AL049610, BC093013, DA268606
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    Q15014
    Conserved Domains (1) summary
    pfam05712
    Location:110276
    MRG
  6. NM_001142423.2NP_001135895.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135895.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AL049610, BC093013
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    Q15014
    Conserved Domains (1) summary
    pfam05712
    Location:110276
    MRG
  7. NM_001142424.2NP_001135896.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135896.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    BC093013
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    Q15014
    Conserved Domains (1) summary
    pfam05712
    Location:110276
    MRG
  8. NM_001142425.2NP_001135897.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135897.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AL049610, BC093013, DA987770
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    Q15014
    Conserved Domains (1) summary
    pfam05712
    Location:110276
    MRG
  9. NM_001142426.2NP_001135898.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135898.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AL049610, BC093013, DA987770
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    Q15014
    Related
    ENSP00000410532.1, ENST00000451301.5
    Conserved Domains (1) summary
    pfam05712
    Location:110276
    MRG
  10. NM_001142427.2NP_001135899.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135899.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    BC093013, BM835303
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    Q15014
    Conserved Domains (1) summary
    pfam05712
    Location:110276
    MRG
  11. NM_001142428.2NP_001135900.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135900.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    BC093013, DA068448
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    Q15014
    Conserved Domains (1) summary
    pfam05712
    Location:110276
    MRG
  12. NM_001142429.2NP_001135901.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135901.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    BC093013, DC301727
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    Q15014
    Conserved Domains (1) summary
    pfam05712
    Location:110276
    MRG
  13. NM_001142430.2NP_001135902.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135902.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    BC093013, BM471743, DA987770
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    Q15014
    Conserved Domains (1) summary
    pfam05712
    Location:110276
    MRG
  14. NM_001142431.2NP_001135903.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135903.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    BC093013, DA268606, DC366195
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    Q15014
    Conserved Domains (1) summary
    pfam05712
    Location:110276
    MRG
  15. NM_001142432.2NP_001135904.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001135904.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    BC093013, DC424668
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    Q15014
    Conserved Domains (1) summary
    pfam05712
    Location:110276
    MRG
  16. NM_012286.3NP_036418.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_036418.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AL049610, BC093013, DA987770
    Consensus CDS
    CCDS14512.1
    UniProtKB/Swiss-Prot
    Q15014
    Related
    ENSP00000391969.2, ENST00000441076.7
    Conserved Domains (1) summary
    pfam05712
    Location:110276
    MRG

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    103675498..103688047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    102122473..102135021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)