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    Acpp acid phosphatase, prostate [ Mus musculus (house mouse) ]

    Gene ID: 56318, updated on 31-Jan-2019

    Summary

    Official Symbol
    Acppprovided by MGI
    Official Full Name
    acid phosphatase, prostateprovided by MGI
    Primary source
    MGI:MGI:1928480
    See related
    Ensembl:ENSMUSG00000032561
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lap; PAP; FRAP; Ppal; 5'-NT; A030005E02Rik
    Expression
    Broad expression in genital fat pad adult (RPKM 3.4), adrenal adult (RPKM 2.3) and 17 other tissues See more
    Orthologs

    Genomic context

    See Acpp in Genome Data Viewer
    Location:
    9; 9 F1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (104288240..104337722, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (104190570..104240052, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C13 Neighboring gene high mobility group box 1, related sequence 16 Neighboring gene predicted gene, 46130 Neighboring gene predicted gene 28548 Neighboring gene nuclear encoded tRNA cysteine 47 (anticodon GCA)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    5'-nucleotidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acid phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acid phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    choline binding ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    lysophosphatidic acid phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    thiamine phosphate phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    adenosine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenosine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of adenosine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    purine nucleobase metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    thiamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi cisterna ISO
    Inferred from Sequence Orthology
    more info
     
    apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    multivesicular body ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    prostatic acid phosphatase
    Names
    5'-nucleotidase
    TMPase
    ecto-5'-nucleotidase
    fluoride-resistant acid phosphatase
    lysosomal acid phosphatase
    thiamine monophosphatase
    NP_062781.2
    NP_997551.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019807.2NP_062781.2  prostatic acid phosphatase isoform 2 precursor

      See identical proteins and their annotated locations for NP_062781.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 3' terminal exon compared to variant 1. The encoded isoform (2, also known as PAP) is shorter and has a distinct C-terminus compared to isoform 1. This isoform is a secreted protein.
      Source sequence(s)
      AK029273, AK076383, CD770300
      Consensus CDS
      CCDS40750.1
      UniProtKB/Swiss-Prot
      Q8CE08
      Related
      ENSMUSP00000108209.2, ENSMUST00000112590.2
      Conserved Domains (1) summary
      cd07061
      Location:33331
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
    2. NM_207668.2NP_997551.1  prostatic acid phosphatase isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1, also known as TM-PAP). This isoform is a transmembrane protein.
      Source sequence(s)
      AC127422, AK029273, AK076383
      Consensus CDS
      CCDS23460.1
      UniProtKB/Swiss-Prot
      Q8CE08
      Related
      ENSMUSP00000059889.6, ENSMUST00000062723.13
      Conserved Domains (1) summary
      cd07061
      Location:33331
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      104288240..104337722 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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