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ACPP acid phosphatase, prostate [ Homo sapiens (human) ]

Gene ID: 55, updated on 6-Jan-2019

Summary

Official Symbol
ACPPprovided by HGNC
Official Full Name
acid phosphatase, prostateprovided by HGNC
Primary source
HGNC:HGNC:125
See related
Ensembl:ENSG00000014257 MIM:171790
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACP3; 5'-NT; ACP-3
Summary
This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]
Expression
Restricted expression toward prostate (RPKM 1149.8) See more
Orthologs

Genomic context

See ACPP in Genome Data Viewer
Location:
3q22.1
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (132317367..132368765)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (132036211..132087146)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene copine 4 Neighboring gene tRNA-Cys (GCA) 9-1 Neighboring gene ribosomal protein L7 pseudogene 16 Neighboring gene g2/M phase-specific E3 ubiquitin-protein ligase-like Neighboring gene NIP7 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
PubMed 
acid phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
lysophosphatidic acid phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
thiamine phosphate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
adenosine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of adenosine receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein homotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
purine nucleobase metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
thiamine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
azurophil granule membrane TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IMP
Inferred from Mutant Phenotype
more info
PubMed 
filopodium IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane HDA PubMed 
nucleus HDA PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
prostatic acid phosphatase
Names
TMPase
ecto-5'-nucleotidase
prostatic acid phosphotase
thiamine monophosphatase
NP_001090.2
NP_001127666.1
NP_001278966.1
XP_011511248.1
XP_011511249.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047032.1 RefSeqGene

    Range
    5001..55936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001099.5NP_001090.2  prostatic acid phosphatase isoform PAP precursor

    See identical proteins and their annotated locations for NP_001090.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the shorter, secreted isoform (PAP).
    Source sequence(s)
    AA578274, AC020633, BC008493, BC016344
    Consensus CDS
    CCDS3073.1
    UniProtKB/Swiss-Prot
    P15309
    Related
    ENSP00000337471.5, ENST00000336375.9
    Conserved Domains (1) summary
    cd07061
    Location:34332
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
  2. NM_001134194.1NP_001127666.1  prostatic acid phosphatase isoform TM-PAP precursor

    See identical proteins and their annotated locations for NP_001127666.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs at the 3' end compared to variant 1 and encodes a longer isoform (TM-PAP) with a distinct C-terminus compared to isoform PAP. TM-PAP is a type 1 transmembrane protein.
    Source sequence(s)
    AW136372, BC007460, BC008493, BQ100881, DC383453
    Consensus CDS
    CCDS46916.1
    UniProtKB/Swiss-Prot
    P15309
    Related
    ENSP00000323036.8, ENST00000351273.11
    Conserved Domains (1) summary
    cd07061
    Location:34332
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
  3. NM_001292037.1NP_001278966.1  prostatic acid phosphatase isoform 3

    See identical proteins and their annotated locations for NP_001278966.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform PAP.
    Source sequence(s)
    AC020633, AK300540, DC383453
    Consensus CDS
    CCDS77818.1
    UniProtKB/Swiss-Prot
    P15309
    Related
    ENSP00000417744.1, ENST00000475741.5
    Conserved Domains (1) summary
    cd07061
    Location:34299
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    132317367..132368765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512947.2XP_011511249.1  prostatic acid phosphatase isoform X2

    Conserved Domains (1) summary
    cd07061
    Location:34299
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
  2. XM_011512946.1XP_011511248.1  prostatic acid phosphatase isoform X1

    Conserved Domains (1) summary
    cd07061
    Location:34332
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
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