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    TEX15 testis expressed 15, meiosis and synapsis associated [ Homo sapiens (human) ]

    Gene ID: 56154, updated on 5-May-2024

    Summary

    Official Symbol
    TEX15provided by HGNC
    Official Full Name
    testis expressed 15, meiosis and synapsis associatedprovided by HGNC
    Primary source
    HGNC:HGNC:11738
    See related
    Ensembl:ENSG00000133863 MIM:605795; AllianceGenome:HGNC:11738
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT42; SPGF25
    Summary
    This gene encodes a protein that is required for DNA double-strand break repair, chromosome synapsis, and meiotic recombination in spermatocytes. Male mice with a knockout of the orthologous gene are viable but sterile. Loss-of-function mutations in the orthologous mouse gene cause early meiotic arrest in spermatocytes, before the mid-pachytene stage. Naturally occurring mutations in this gene are associated with nonobstructive azoospermia. [provided by RefSeq, Apr 2017]
    Expression
    Biased expression in testis (RPKM 7.9) and endometrium (RPKM 3.5) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TEX15 in Genome Data Viewer
    Location:
    8p12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (30831544..30913008, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (31112556..31194025, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (30689060..30770524, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene UBX domain protein 8 Neighboring gene HIKESHI pseudogene 3 Neighboring gene protein phosphatase 2 catalytic subunit beta Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19085 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19087 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19088 Neighboring gene uncharacterized LOC105379357 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:30763109-30763340 Neighboring gene CRISPRi-validated cis-regulatory element chr8.1136 Neighboring gene NANOG hESC enhancer GRCh37_chr8:30776396-30776897 Neighboring gene lysophosphatidylglycerol acyltransferase 1 pseudogene 1 Neighboring gene MPRA-validated peak6979 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19091 Neighboring gene purine rich element binding protein G

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp434M2415

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    acts_upstream_of_or_within_positive_effect DNA methylation-dependent heterochromatin formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in male meiotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT involved_in piRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retrotransposon silencing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptonemal complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    testis-expressed protein 15
    Names
    cancer/testis antigen 42
    testis-expressed sequence 15 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053141.1 RefSeqGene

      Range
      5005..86469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001350162.2NP_001337091.1  testis-expressed protein 15

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      AC090281, AF285605, AL133653, BC141841
      Consensus CDS
      CCDS87593.1
      UniProtKB/TrEMBL
      A0A1W2PS94, A0A2R8Y358
      Related
      ENSP00000493555.1, ENST00000643185.2
      Conserved Domains (2) summary
      pfam12509
      Location:103250
      DUF3715; Protein of unknown function (DUF3715)
      pfam15326
      Location:19212153
      TEX15; Testis expressed sequence 15

    RNA

    1. NR_146525.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the polyadenylated site occurs disrupts the open reading frame, suggesting that the transcript may be a candidate for non-stop decay.
      Source sequence(s)
      AC090281, BC141841

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      30831544..30913008 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      31112556..31194025 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)