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Tex15 testis expressed gene 15 [ Mus musculus (house mouse) ]

Gene ID: 104271, updated on 26-Sep-2022

Summary

Official Symbol
Tex15provided by MGI
Official Full Name
testis expressed gene 15provided by MGI
Primary source
MGI:MGI:1934816
See related
Ensembl:ENSMUSG00000009628 AllianceGenome:MGI:1934816
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2210014E14Rik
Summary
Involved in DNA methylation and negative regulation of transposition. Acts upstream of or within several processes, including male gamete generation; regulation of double-strand break repair via homologous recombination; and synaptonemal complex assembly. Located in cytoplasm and nucleus. Is expressed in meninges; oocyte; sensory organ; and spinal cord mantle layer. Human ortholog(s) of this gene implicated in spermatogenic failure 25. Orthologous to human TEX15 (testis expressed 15, meiosis and synapsis associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 4.1), testis adult (RPKM 3.8) and 10 other tissues See more
Orthologs
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Genomic context

See Tex15 in Genome Data Viewer
Location:
8; 8 A4
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (34006712..34082531)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (33516689..33592503)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene translocase of outer mitochondrial membrane 40 homolog pseudogene Neighboring gene high mobility group box 1, related sequence 17 Neighboring gene protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform Neighboring gene UBX domain protein 8 Neighboring gene predicted gene, 33433

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within_positive_effect DNA methylation-dependent heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within RNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within fertilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within homeostasis of number of cells within a tissue IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within male genitalia development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in male meiotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within male meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transposition IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in piRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein localization to chromosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptonemal complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within synaptonemal complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
testis-expressed protein 15
Names
testis-expressed sequence 15 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031374.2NP_113551.2  testis-expressed protein 15

    See identical proteins and their annotated locations for NP_113551.2

    Status: VALIDATED

    Source sequence(s)
    AC139025, AF285589, BC063106
    Consensus CDS
    CCDS22232.1
    UniProtKB/Swiss-Prot
    F8VPN2, Q99MV3
    Related
    ENSMUSP00000009772.8, ENSMUST00000009772.8
    Conserved Domains (1) summary
    pfam15326
    Location:15741788
    TEX15; Testis expressed sequence 15

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    34006712..34082531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508976.4XP_006509039.1  testis-expressed protein 15 isoform X1

    See identical proteins and their annotated locations for XP_006509039.1

    Conserved Domains (2) summary
    pfam12509
    Location:104251
    DUF3715; Protein of unknown function (DUF3715)
    pfam15326
    Location:18482062
    TEX15; Testis expressed sequence 15
  2. XM_006508977.4XP_006509040.1  testis-expressed protein 15 isoform X1

    See identical proteins and their annotated locations for XP_006509040.1

    Conserved Domains (2) summary
    pfam12509
    Location:104251
    DUF3715; Protein of unknown function (DUF3715)
    pfam15326
    Location:18482062
    TEX15; Testis expressed sequence 15
  3. XM_006508975.3XP_006509038.1  testis-expressed protein 15 isoform X1

    See identical proteins and their annotated locations for XP_006509038.1

    Conserved Domains (2) summary
    pfam12509
    Location:104251
    DUF3715; Protein of unknown function (DUF3715)
    pfam15326
    Location:18482062
    TEX15; Testis expressed sequence 15
  4. XM_011242106.2XP_011240408.1  testis-expressed protein 15 isoform X1

    See identical proteins and their annotated locations for XP_011240408.1

    Conserved Domains (2) summary
    pfam12509
    Location:104251
    DUF3715; Protein of unknown function (DUF3715)
    pfam15326
    Location:18482062
    TEX15; Testis expressed sequence 15

RNA

  1. XR_378774.2 RNA Sequence

  2. XR_004934745.1 RNA Sequence