U.S. flag

An official website of the United States government


Send to:

Choose Destination
    • Showing Current items.

    ARGLU1 arginine and glutamate rich 1 [ Homo sapiens (human) ]

    Gene ID: 55082, updated on 7-Apr-2024


    Official Symbol
    ARGLU1provided by HGNC
    Official Full Name
    arginine and glutamate rich 1provided by HGNC
    Primary source
    See related
    Ensembl:ENSG00000134884 MIM:614046; AllianceGenome:HGNC:25482
    Gene type
    protein coding
    RefSeq status
    Homo sapiens
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Enables cadherin binding activity. Located in cytosol; mitochondrion; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Ubiquitous expression in lung (RPKM 83.2), spleen (RPKM 81.9) and 25 other tissues See more
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ARGLU1 in Genome Data Viewer
    Exon count:
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (106541673..106568137, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (105762093..105788553, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (107194021..107220485, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:107124121-107125320 Neighboring gene uncharacterized LOC105370346 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:107125598-107126285 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr13:107131600-107132799 Neighboring gene uncharacterized LOC124903247 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:107144828-107145328 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:107145476-107146675 Neighboring gene ephrin B2 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:107178953-107179606 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5489 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5490 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7982 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:107219841-107220751 Neighboring gene ARGLU1 divergent transcript Neighboring gene long intergenic non-protein coding RNA 443 Neighboring gene ATP synthase membrane subunit c locus 1 pseudogene 5

    Genomic regions, transcripts, and products


    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018


    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of arginine and glutamate rich 1 (ARGLU1; FLJ 10154) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database


    Products Interactant Other Gene Complex Source Pubs Description

    General gene information


    Clone Names

    • FLJ10154, DKFZp686O08106

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cadherin binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info

    General protein information

    Preferred Names
    arginine and glutamate-rich protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018011.4NP_060481.3  arginine and glutamate-rich protein 1

      See identical proteins and their annotated locations for NP_060481.3

      Status: VALIDATED

      Source sequence(s)
      AA445997, AI623424, AL442127, BC050434, DB482545
      Consensus CDS
      B4E0Y3, Q5T257, Q6IQ34, Q9NWB6
      ENSP00000383059.3, ENST00000400198.8
      Conserved Domains (1) summary
      ARGLU; Arginine and glutamate-rich 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly


    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      106541673..106568137 complement
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0


    1. NC_060937.1 Alternate T2T-CHM13v2.0

      105762093..105788553 complement
      GenBank, FASTA, Sequence Viewer (Graphics)