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    TMED9 transmembrane p24 trafficking protein 9 [ Homo sapiens (human) ]

    Gene ID: 54732, updated on 9-Jun-2024

    Summary

    Official Symbol
    TMED9provided by HGNC
    Official Full Name
    transmembrane p24 trafficking protein 9provided by HGNC
    Primary source
    HGNC:HGNC:24878
    See related
    Ensembl:ENSG00000184840 MIM:620436; AllianceGenome:HGNC:24878
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p25; GMP25; p24a2; HSGP25L2G; p24alpha2
    Summary
    This gene is a member of a family of genes encoding transport proteins located in the endoplasmic reticulum and the Golgi. A similar gene in mouse is the target of microRNA miR-296, which is part of an imprinted cluster. [provided by RefSeq, Jul 2016]
    Expression
    Ubiquitous expression in placenta (RPKM 102.0), colon (RPKM 69.9) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TMED9 in Genome Data Viewer
    Location:
    5q35.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (177592203..177597242)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (178134482..178139521)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (177019204..177024243)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 193 member B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16702 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:176981263-176981766 Neighboring gene CRISPRi-validated cis-regulatory element chr5.4836 Neighboring gene FAM193B divergent transcript Neighboring gene CRISPRi-validated cis-regulatory element chr5.4837 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:177020409-177021608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23732 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:177033623-177034226 Neighboring gene beta-1,4-galactosyltransferase 7 Neighboring gene SIMC1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16705 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16706

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev is identified to have a physical interaction with transmembrane emp24 protein transport domain containing 9 (TMED9) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cargo receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables syntaxin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in COPI coating of Golgi vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in COPI coating of Golgi vesicle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in early endosome to Golgi transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of organelle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in protein exit from endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    transmembrane emp24 domain-containing protein 9
    Names
    glycoprotein 25L2
    p24 family protein alpha-2
    transmembrane emp24 protein transport domain containing 9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051237.1 RefSeqGene

      Range
      5056..10095
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_017510.6NP_059980.2  transmembrane emp24 domain-containing protein 9 precursor

      See identical proteins and their annotated locations for NP_059980.2

      Status: REVIEWED

      Source sequence(s)
      AC139795, BC001123, BP290332
      Consensus CDS
      CCDS4428.1
      UniProtKB/Swiss-Prot
      Q14437, Q8WZ61, Q9BVK6
      UniProtKB/TrEMBL
      B2R8A2
      Related
      ENSP00000330945.6, ENST00000332598.7
      Conserved Domains (1) summary
      pfam01105
      Location:37230
      EMP24_GP25L; emp24/gp25L/p24 family/GOLD

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      177592203..177597242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      178134482..178139521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)