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    Rcan3 regulator of calcineurin 3 [ Mus musculus (house mouse) ]

    Gene ID: 53902, updated on 8-Feb-2024

    Summary

    Official Symbol
    Rcan3provided by MGI
    Official Full Name
    regulator of calcineurin 3provided by MGI
    Primary source
    MGI:MGI:1858220
    See related
    Ensembl:ENSMUSG00000059713 AllianceGenome:MGI:1858220
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Csp3; Dscr1l2
    Summary
    Predicted to enable calcium-dependent protein serine/threonine phosphatase regulator activity; phosphatase binding activity; and troponin I binding activity. Predicted to be involved in calcium-mediated signaling. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human RCAN3 (RCAN family member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 17.8), CNS E18 (RPKM 16.6) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Rcan3 in Genome Data Viewer
    Location:
    4 D3; 4 67.59 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135139619..135161154, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (135412308..135433871, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene serine/arginine repetitive matrix 1 Neighboring gene STARR-positive B cell enhancer ABC_E6233 Neighboring gene noncompact myelin associated protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:134982608-134982761 Neighboring gene microRNA 700 Neighboring gene STARR-positive B cell enhancer ABC_E9603 Neighboring gene STARR-positive B cell enhancer ABC_E1286 Neighboring gene NIPA-like domain containing 3 Neighboring gene STARR-positive B cell enhancer mm9_chr4:135050361-135050662 Neighboring gene STARR-seq mESC enhancer starr_11721 Neighboring gene sperm tail PG rich repeat containing 1 Neighboring gene STARR-seq mESC enhancer starr_11724 Neighboring gene grainyhead like transcription factor 3 Neighboring gene STARR-positive B cell enhancer ABC_E6235 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135126769-135126952 Neighboring gene predicted gene, 30888

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium-dependent protein serine/threonine phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables troponin I binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    calcipressin-3
    Names
    Down syndrome critical region gene 1-like 2
    MCIP3
    down syndrome candidate region 1-like protein 2
    myocyte-enriched calcineurin-interacting protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419054.1NP_001405983.1  calcipressin-3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL627185
      UniProtKB/Swiss-Prot
      Q3U2I5, Q9CX87, Q9JKK0
    2. NM_001419055.1NP_001405984.1  calcipressin-3 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL627185
      UniProtKB/TrEMBL
      A2A994
      Related
      ENSMUSP00000118447.2, ENSMUST00000156635.2
    3. NM_001419056.1NP_001405985.1  calcipressin-3 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL627185
      UniProtKB/TrEMBL
      A2A994
    4. NM_022980.5NP_075356.1  calcipressin-3 isoform a

      See identical proteins and their annotated locations for NP_075356.1

      Status: VALIDATED

      Source sequence(s)
      AL627185
      Consensus CDS
      CCDS18785.1
      UniProtKB/Swiss-Prot
      Q3U2I5, Q9CX87, Q9JKK0
      Related
      ENSMUSP00000030606.8, ENSMUST00000030606.14
      Conserved Domains (1) summary
      pfam04847
      Location:58225
      Calcipressin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      135139619..135161154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)