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RCAN3 RCAN family member 3 [ Homo sapiens (human) ]

Gene ID: 11123, updated on 1-Jun-2020

Summary

Official Symbol
RCAN3provided by HGNC
Official Full Name
RCAN family member 3provided by HGNC
Primary source
HGNC:HGNC:3042
See related
Ensembl:ENSG00000117602 MIM:605860
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RCN3; MCIP3; hRCN3; DSCR1L2
Expression
Broad expression in prostate (RPKM 18.2), lymph node (RPKM 9.0) and 22 other tissues See more
Orthologs

Genomic context

See RCAN3 in Genome Data Viewer
Location:
1p36.11
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (24502344..24541040)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (24828841..24863510)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 15224 Neighboring gene sperm tail PG-rich repeat containing 1 Neighboring gene NIPA like domain containing 3 Neighboring gene RCAN3 antisense RNA Neighboring gene Sharpr-MPRA regulatory region 2491 Neighboring gene NCMAP divergent transcript Neighboring gene non-compact myelin associated protein Neighboring gene ribosomal protein L26 pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding TAS
Traceable Author Statement
more info
PubMed 
calcium-dependent protein serine/threonine phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
troponin I binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
regulation of calcineurin-NFAT signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
calcipressin-3
Names
Down syndrome candidate region 1-like 2
Down syndrome critical region gene 1-like 2
down syndrome candidate region 1-like protein 2
myocyte-enriched calcineurin-interacting protein 3
regulator of calcineurin 3 isoform 1b,2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001251977.2NP_001238906.1  calcipressin-3 isoform 1

    See identical proteins and their annotated locations for NP_001238906.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform 1.
    Source sequence(s)
    AI697154, AL034582, BC035854, CX752875, HQ317421
    Consensus CDS
    CCDS254.1
    UniProtKB/Swiss-Prot
    Q9UKA8
    UniProtKB/TrEMBL
    A0A024RAH2
    Conserved Domains (1) summary
    pfam04847
    Location:58224
    Calcipressin; Calcipressin
  2. NM_001251978.1NP_001238907.1  calcipressin-3 isoform 1

    See identical proteins and their annotated locations for NP_001238907.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR exon, compared to variant 1. Variants 1-4 encode the same isoform 1.
    Source sequence(s)
    AI697154, AL034582, HQ287726, HQ317423
    Consensus CDS
    CCDS254.1
    UniProtKB/Swiss-Prot
    Q9UKA8
    UniProtKB/TrEMBL
    A0A024RAH2
    Related
    ENSP00000479300.1, ENST00000610732.4
    Conserved Domains (1) summary
    pfam04847
    Location:58224
    Calcipressin; Calcipressin
  3. NM_001251979.2NP_001238908.1  calcipressin-3 isoform 1

    See identical proteins and their annotated locations for NP_001238908.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR exon, compared to variant 1. Variants 1-4 encode the same isoform 1.
    Source sequence(s)
    AI697154, AL034582, BP326714, HQ317421
    Consensus CDS
    CCDS254.1
    UniProtKB/Swiss-Prot
    Q9UKA8
    UniProtKB/TrEMBL
    A0A024RAH2
    Related
    ENSP00000445401.2, ENST00000538532.6
    Conserved Domains (1) summary
    pfam04847
    Location:58224
    Calcipressin; Calcipressin
  4. NM_001251980.1NP_001238909.1  calcipressin-3 isoform 2

    See identical proteins and their annotated locations for NP_001238909.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an in-frame segment in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AF176117, AI697154, AL034582, EF431960, HQ317426
    Consensus CDS
    CCDS57979.1
    UniProtKB/Swiss-Prot
    Q9UKA8
    Related
    ENSP00000409540.2, ENST00000425530.3
    Conserved Domains (1) summary
    pfam04847
    Location:58214
    Calcipressin; Calcipressin
  5. NM_001251981.1NP_001238910.1  calcipressin-3 isoform 3

    See identical proteins and their annotated locations for NP_001238910.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AI697154, AL034582, BC035854, CT001954
    Consensus CDS
    CCDS57981.1
    UniProtKB/Swiss-Prot
    Q9UKA8
    Related
    ENSP00000414447.3, ENST00000436717.6
    Conserved Domains (1) summary
    cl17169
    Location:66166
    RRM_SF; RNA recognition motif (RRM) superfamily
  6. NM_001251982.1NP_001238911.1  calcipressin-3 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an exon in the coding region, which results in a frame-shift, compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI697154, AL034582, EF467309, HQ287726, HQ317426
    Consensus CDS
    CCDS57980.1
    UniProtKB/Swiss-Prot
    Q9UKA8
    Related
    ENSP00000391912.2, ENST00000412742.5
    Conserved Domains (1) summary
    cl17169
    Location:47123
    RRM_SF; RNA recognition motif (RRM) superfamily
  7. NM_001251983.1NP_001238912.1  calcipressin-3 isoform 5

    See identical proteins and their annotated locations for NP_001238912.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks an internal exon, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (5) is shorter at the N-termius, compared to isoform 1.
    Source sequence(s)
    AI697154, AL034582, BC035854, HQ287726
    Consensus CDS
    CCDS72730.1
    UniProtKB/Swiss-Prot
    Q9UKA8
    Related
    ENSP00000478174.1, ENST00000616511.4
    Conserved Domains (1) summary
    cl17169
    Location:299
    RRM_SF; RNA recognition motif (RRM) superfamily
  8. NM_001251984.1NP_001238913.1  calcipressin-3 isoform 5

    See identical proteins and their annotated locations for NP_001238913.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR exon and lacks an internal exon, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (5) is shorter at the N-termius, compared to isoform 1. Variants 8 and 9 encode the same isoform 5.
    Source sequence(s)
    AI697154, AL034582, BP326714, HQ317421, HQ317422
    Consensus CDS
    CCDS72730.1
    UniProtKB/Swiss-Prot
    Q9UKA8
    Related
    ENSP00000484519.1, ENST00000618490.4
    Conserved Domains (1) summary
    cl17169
    Location:299
    RRM_SF; RNA recognition motif (RRM) superfamily
  9. NM_001251985.1NP_001238914.1  calcipressin-3 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) lacks two exons in the coding region, which results in a frame-shift, compared to variant 1. The resulting isoform (6) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI697154, AL034582, AY906854, HQ317426
    Consensus CDS
    CCDS57982.1
    UniProtKB/Swiss-Prot
    Q9UKA8
    Related
    ENSP00000363514.2, ENST00000374393.4
    Conserved Domains (1) summary
    cl17169
    Location:4767
    RRM_SF; RNA recognition motif (RRM) superfamily
  10. NM_013441.4NP_038469.1  calcipressin-3 isoform 1

    See identical proteins and their annotated locations for NP_038469.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1-4 encode the same isoform 1.
    Source sequence(s)
    AI697154, AL034582, BC035854, EF431960
    Consensus CDS
    CCDS254.1
    UniProtKB/Swiss-Prot
    Q9UKA8
    UniProtKB/TrEMBL
    A0A024RAH2
    Related
    ENSP00000363516.3, ENST00000374395.9
    Conserved Domains (1) summary
    pfam04847
    Location:58224
    Calcipressin; Calcipressin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    24502344..24541040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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