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    Tomm40 translocase of outer mitochondrial membrane 40 [ Mus musculus (house mouse) ]

    Gene ID: 53333, updated on 23-Jun-2021

    Summary

    Official Symbol
    Tomm40provided by MGI
    Official Full Name
    translocase of outer mitochondrial membrane 40provided by MGI
    Primary source
    MGI:MGI:1858259
    See related
    Ensembl:ENSMUSG00000002984
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tom4; Mom35; Tom40; AW539759
    Expression
    Ubiquitous expression in adrenal adult (RPKM 63.6), ovary adult (RPKM 47.8) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tomm40 in Genome Data Viewer
    Location:
    7; 7 A3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19435238..19449370, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19701313..19715442, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (20286662..20300778, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene apolipoprotein C-I Neighboring gene apolipoprotein E Neighboring gene predicted gene, 38955 Neighboring gene nectin cell adhesion molecule 2 Neighboring gene predicted gene, 34744 Neighboring gene basal cell adhesion molecule

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC118268

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cation channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables porin activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables preprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein import into mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein insertion into mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondria-associated endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of mitochondrial outer membrane translocase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of mitochondrial outer membrane translocase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    part_of pore complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mitochondrial import receptor subunit TOM40 homolog
    Names
    haymaker protein
    mitochondrial outer membrane protein 35
    mitochondrial outer membrane protein of 35 kDa
    translocase of outer membrane 40 kDa subunit homolog
    translocase of outer mitochondrial membrane 40 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109748.1NP_001103218.1  mitochondrial import receptor subunit TOM40 homolog

      See identical proteins and their annotated locations for NP_001103218.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK150019, AK165173, AW493492, BY231811
      Consensus CDS
      CCDS52062.1
      UniProtKB/Swiss-Prot
      Q9QYA2
      Related
      ENSMUSP00000032555.10, ENSMUST00000032555.10
      Conserved Domains (1) summary
      cd07305
      Location:77361
      Porin3_Tom40; Translocase of outer mitochondrial membrane 40 (Tom40)
    2. NM_016871.2NP_058567.2  mitochondrial import receptor subunit TOM40 homolog

      See identical proteins and their annotated locations for NP_058567.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK165173, AW493492, BY231811
      Consensus CDS
      CCDS52062.1
      UniProtKB/Swiss-Prot
      Q9QYA2
      Related
      ENSMUSP00000104090.5, ENSMUST00000093552.12
      Conserved Domains (1) summary
      cd07305
      Location:77361
      Porin3_Tom40; Translocase of outer mitochondrial membrane 40 (Tom40)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      19435238..19449370 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242769.2XP_030098629.1  mitochondrial import receptor subunit TOM40 homolog isoform X1

      Conserved Domains (1) summary
      cd07305
      Location:1208
      Porin3_Tom40; Translocase of outer mitochondrial membrane 40 (Tom40)
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