Conserved Protein Domain Family
Porin3_Tom40

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cd07305: Porin3_Tom40 
Translocase of outer mitochondrial membrane 40 (Tom40)
Tom40 forms a channel in the mitochondrial outer membrane with a pore about 1.5 to 2.5 nanometers wide. It functions as a transport channel for unfolded protein chains and forms a complex with Tom5, Tom6, Tom7, and Tom22. The primary receptors Tom20 and Tom70 recruit the unfolded precursor protein from the mitochondrial-import stimulating factor (MSF) or cytosolic Hsc70. The precursor passes through the Tom40 channel and through another channel in the inner membrane, formed by Tim23, to be finally translocated into the mitochondrial matrix. The process depends on a proton motive force across the inner membrane and requires a contact site where the outer and inner membranes come close. Tom40 is also involved in inserting outer membrane proteins into the membrane, most likely not via a lateral opening in the pore, but by transfering precursor proteins to an outer membrane sorting and assembly machinery.
Links
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Statistics
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PSSM-Id: 132766
View PSSM: cd07305
Aligned: 53 rows
Threshold Bit Score: 195.12
Threshold Setting Gi: 220067147
Created: 4-Mar-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
Hierarchy
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Display:
PubMed ReferencesClick to see Conserved Features Help

cd07305 is part of a hierarchy of related CD models.
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cd07305 is a member of the superfamily cl03224.
cd07303:Porin3cd07305:Porin3_Tom40cd07306:Porin3_VDAC66818277220067147190742981272183994786221871309618920778350557354124912162312192170088344195610654164657951134107942224009574219123953168063053167998937116056780136320861522296315948918082594999156089779849980182098815406636223621196828015863452216178430514823665347085743818811161675551582210909451563827667203995519599556919842653812643867212512692198461250122303721705907027615486119368352119359206948095577156547679195133528195456948246472181455353556681827722006714719074298127218399478622187130961892077835055735412491216231219217008834419561065416465795113410794222400957421912395316806305316799893711605678013632086152229631594891808259499915608977984998018209881540663622362119682801586345221617843051482366534708574381881116167555158221090945156382766720399551959955691984265381264386721251269219846125012230372170590702761548611936835211935920694809557715654767919513352819545694824647218145535355
cd07305 Sequence Cluster
cd07305 Sequence Cluster
Sub-family Hierarchy
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 cd07305 Branch
 Whole Hierarchy
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161784305  77 LPNPGTFEECHRKCKELFPVQMe--GVKLTVNKGLSNRFQVTHTVALGtig--------------esnYHFGVTYVGTKq 140
gi 158634522  10 RTNPGRTDDFQREAKEILTPDLf-dGLRVEIGQSLSQNLGLTHSFVMGsstv-------------pshYQLGANYLRDK- 74
gi 82594999  100 APNALLFENLNKEYKYITTQDNf-dGFRFEVDKNVNKYLQSTHTLFLGtslrd-----------vgylYQFGANFANSDn 167
gi 156089779 104 PYELLVFENLTREFKNVITQDNy-dGFRLEADRQLTNNLQLSHSLYLGtvmse-----------tgylYQIGTNYASSDg 171
gi 84998018   96 PFDLLVYENLAREYKNVITQDNy-dGFRLEADRQLTKNLQASHSLYLGtllkd-----------vgyiYQIGANYASDDg 163
gi 209881540   8 PEQSIQYEHFSKEVHNVLQQDNf-dGFRAEIAKNVTRNLQSSHTILLGtird------------kgymYQFGPSYQSADg 74
gi 66362236   15 TNKSLQYENFSLESQSIFQRESf-dGFRAEIAKSVTSNLQTSYSLFLGtsni------------kgysYQLGPSYQSSSk 81
gi 211968280 155 APIPVPYEQFSREWMAVAGQDNf-dGFRLEATKQVNKVLTANHTFMLGtqske-----------ggcsYSFGPTLVIGEp 222
gi 66818277   39 LPYPGKAEDMISEVKGLVNDDIy-eGAKVDVTFKISPFFETSHQLNVYtpnen----------srtpkYSNQNVYSKDS- 106
gi 145535355  42 PRRPPLFDGLLNNVRAVTKKVEhikGFKFEVAGGLSNNFHLAHSWMIPpsskgkapnpnpmkqppvpsYTLAAQYLGGEl 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161784305 141 lsp---teafPVLVGD--MDNSGSLNAQVIHQLSp--GLRSKMAIQTQQs--KFVNWQVDGEYRG-SDFTAAVTLGNPdv 210
gi 158634522  75 ----------IFVTGR--FDHAGRLSGAVRVQPLk--ELASKFEFLLGRs-kAECGCLAEVELRG-RDFTGELQASSA-- 136
gi 82594999  168 ---------tLLMISR--INLDGSVNGRFCKKINn--FVDCKFNFNTYNksdPRNMYEMSLEVNN-PQNTYNIKTIWQg- 232
gi 156089779 172 ---------nCLAMGK--IGLDGMLTGRVFAKYAd-cEFKVSGNSFLRYd--TRNAYEAGVDYFG-KGWTASLKGAWQg- 235
gi 84998018  164 ---------kKFLMFK--VGLDGNIALKAFAKLGd--RLELKAVTNSRLkidNQSTFEVGADYLS-DYWTATLKCCWQg- 228
gi 209881540  75 ---------kTMVLSR--IGTDGMVNTRLSRRFGn--NIDCKFSSSSSInheERNMSELSLEYNG-FDWSACIKAAYNg- 139
gi 66362236   82 ---------nTLILAR--VNDEGTVSGRFSRCFGnniEGRISINSSLSDe--NKNMSEVSIDYNG-EESSYSLKVAYQg- 146
gi 211968280 223 deaaqqegqmPNFFGMarMNSDGFLQARFIKAISktfDIKFNSNSSISEdakDKSMYEVSFDKMG-SDWAANLKLAWQg- 300
gi 66818277  107 ----------TLLYGK--IDSERRLFGRFDQGFFn-nSIRVSLTNMMDKs--FKNNLAGELEFKL-PFMNFCLKADTE-- 168
gi 145535355 122 rtpf--dqpsYIMTGR--WDSTGKLEAAIIKKLNe--TFNFRFSAFYLDs--SPNNAQVHLDCDIsGEDYVHSIKLGT-- 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161784305 211 lvgsGILVAHYLQSITPCLALGGELVYHrrPGEEGTVMSLAGKYtl--nnWLATVTLGQ--------------AGMHATY 274
gi 158634522 137 ----GATTARWHQAVTDRVSVVGEGVYH--RAKKVSLLQGGLRFat--pdSVTTLSGSSm-------------GQLITSY 195
gi 82594999  233 ---aWIFNASYTQLLTKKLQAGVDLTYI--GSNCASIGSFGLRYnh--knHVLTMQCIRqpnfkspefmlnqaHSYKMQY 305
gi 156089779 236 ---tWILNAAYTHQLLPCLTLGSELTYI--VANGTSIGAIAARYvr--gdHVFTGQWSKqpnfkgmdynlqdtDTCRLQY 308
gi 84998018  229 ---tFIWNICYTHQILPCFTVGSEVTYI--DANGASIGSLSARYvr--gdNIFTCQLTRqpdfkrmdfskkeiNCARVQY 301
gi 209881540 140 ---tGLLNGSYSQVITPKLQLGGELTWI--SANCTSIMAIGSRYri--gkNTIFTQISRqpdfstlqgmlsnsHSIKSSF 212
gi 66362236  147 ---iFLLNGLFSQLITNKLQLGGELTWI--AANNTSIMSLGSRYch--gkNIFFNQITRqpdftspgrifaniHSLRSSF 219
gi 211968280 301 ---tWILNGLFSQVITPKLQLGGELTWV--AATGISMGSVGARYgfn-enNTVTCQIGVgpdfsspmgfandvYSTKAQY 374
gi 66818277  169 ----NQRGFSFLTSISKKLAIGYENSYLfnHSQSIKQIQFFVNNp----lSTWSLVVGNt-------------AQIGSSY 227
gi 145535355 192 ----GLYSFNMMQTIGKRLVLGYEMMTL--TERNMSLMSYAFKFginpkqNLYAQYVGAa-------------DQLILAY 252
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161784305 275 YHKASDqLQVGVEFEASt---rMQDTSASFGYQLDLPkaNFLFKGSVNSNWIVGATLEKKLpPLPLTLSLCAFLNhrknK 351
gi 158634522 196 THSLTDrLSLATELFMQp---rTHDAIFSVGYQVKLR--KAIVRGMVVSNGRVMASVKDEI-APNTALLLSGDLNylanE 269
gi 82594999  306 ARKISDrLSVGTELEVTp---eTKESAMRLGWDYSFR--HAKVQGSIDSSGKIAVFTQDYS-GFGVSGYIDYLNN----E 375
gi 156089779 309 VRRVNErLSLCTELEVTp---aTKESALRVGWDYLFR--HARVQGNIDTAGRISMQAQDYS-GFGISGCIDYWSN----I 378
gi 84998018  302 TRKVNDrLSLATELELSp---sIKESALRVGWEYLFR--HARVQGNIDSCGRIAMQTQDYN-GFGVSGCIDYWNN----I 371
gi 209881540 213 CRKVSDrLSLATELECTw---pNYESSLKLGYEYLFK--TARIQGMIDTGGRLSMQCQDVQ-GFGISGMIDYLKS----D 282
gi 66362236  220 YRKLSDrLSLASELEVSi---pNFESTLRFGYEYLFK--TARIQGMIDTCGKISLQCLDNK-GFGISAAIDYLRN----D 289
gi 211968280 375 VRKVTDrLSMGTELEFTh---pDMSSAMRVGWQYLFR--QARVQGLVDTAGRVSMFAQDYN-GFGLSGMIDYWHG----D 444
gi 66818277  228 VYRQKN-LHIGTDLVMGisqegKFMSEYSFGVRYAFQ--QSLVKFRADSHGSIFGSYDQMI-NSFTKLNLSGSLNyfaqD 303
gi 145535355 253 NHRILDkAYFMSELEYSn---qTGESRTILGYRQKFA--TSEVIITINSKMKFSSNLTLQGfAYQLKLCAIADYNk--dS 325
                        330
                 ....*....|
gi 161784305 352 FLCGFGLTIG 361
gi 158634522 270 YKFGLGLILG 279
gi 82594999  376 YKFGFMMHIA 385
gi 156089779 379 YRFGFMMHLL 388
gi 84998018  372 YRFGFMMHLL 381
gi 209881540 283 YRFGFMMQFM 292
gi 66362236  290 YKFGFMMQFF 299
gi 211968280 445 YKFGFQMNVV 454
gi 66818277  304 YKFGLGLTFQ 313
gi 145535355 326 YKFGYGIAMG 335
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