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    Kctd18 potassium channel tetramerisation domain containing 18 [ Mus musculus (house mouse) ]

    Gene ID: 51960, updated on 8-Feb-2024

    Summary

    Official Symbol
    Kctd18provided by MGI
    Official Full Name
    potassium channel tetramerisation domain containing 18provided by MGI
    Primary source
    MGI:MGI:3603813
    See related
    Ensembl:ENSMUSG00000054770 AllianceGenome:MGI:3603813
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4932411A20Rik; 6530404F10Rik
    Summary
    Is expressed in central nervous system and retina. Orthologous to human KCTD18 (potassium channel tetramerization domain containing 18). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 4.0), CNS E14 (RPKM 3.8) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Kctd18 in Genome Data Viewer
    Location:
    1 C1.3; 1 28.86 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (57994260..58009298, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (57955101..57970141, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00995 Neighboring gene STARR-seq mESC enhancer starr_00996 Neighboring gene predicted gene, 57573 Neighboring gene spermatogenesis associated, serine-rich 2-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:57896765-57896993 Neighboring gene STARR-seq mESC enhancer starr_00998 Neighboring gene predicted gene, 57576 Neighboring gene STARR-positive B cell enhancer ABC_E7730 Neighboring gene STARR-seq mESC enhancer starr_01001 Neighboring gene shugoshin 2A Neighboring gene STARR-seq mESC enhancer starr_01003 Neighboring gene aldehyde oxidase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General protein information

    Preferred Names
    BTB/POZ domain-containing protein KCTD18

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159864.1NP_001153336.1  BTB/POZ domain-containing protein KCTD18 isoform 1

      See identical proteins and their annotated locations for NP_001153336.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC110735, AK132699, BB678909, BY080515, BY736102
      Consensus CDS
      CCDS48269.1
      UniProtKB/TrEMBL
      E0CZ26
      Related
      ENSMUSP00000110052.4, ENSMUST00000114410.10
      Conserved Domains (2) summary
      cd18372
      Location:23123
      BTB_POZ_KCTD18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 18 (KCTD18)
      pfam17669
      Location:339414
      DUF5529; Family of unknown function (DUF5529)
    2. NM_001159865.1NP_001153337.1  BTB/POZ domain-containing protein KCTD18 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BB678909, BC075692, BY080515, CA530605
      Consensus CDS
      CCDS48268.1
      UniProtKB/TrEMBL
      E9Q945
      Related
      ENSMUSP00000130952.2, ENSMUST00000164963.8
      Conserved Domains (1) summary
      cl38908
      Location:23107
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    RNA

    1. NR_027630.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' end and at the 3' end of an internal exon compared to variant 1. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD) and is therefore thought to be a noncoding transcript.
      Source sequence(s)
      BB678909, BC075692
      Related
      ENSMUST00000161608.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      57994260..58009298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496136.5XP_006496199.1  BTB/POZ domain-containing protein KCTD18 isoform X1

      See identical proteins and their annotated locations for XP_006496199.1

      UniProtKB/TrEMBL
      E0CZ26
      Conserved Domains (2) summary
      cd18372
      Location:23123
      BTB_POZ_KCTD18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 18 (KCTD18)
      pfam17669
      Location:339414
      DUF5529; Family of unknown function (DUF5529)
    2. XM_036152324.1XP_036008217.1  BTB/POZ domain-containing protein KCTD18 isoform X3

      UniProtKB/TrEMBL
      E9Q945
      Conserved Domains (1) summary
      cl38908
      Location:23107
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    3. XM_006496135.4XP_006496198.1  BTB/POZ domain-containing protein KCTD18 isoform X1

      See identical proteins and their annotated locations for XP_006496198.1

      UniProtKB/TrEMBL
      E0CZ26
      Conserved Domains (2) summary
      cd18372
      Location:23123
      BTB_POZ_KCTD18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 18 (KCTD18)
      pfam17669
      Location:339414
      DUF5529; Family of unknown function (DUF5529)
    4. XM_017321677.3XP_017177166.1  BTB/POZ domain-containing protein KCTD18 isoform X4

    5. XM_017321676.3XP_017177165.1  BTB/POZ domain-containing protein KCTD18 isoform X2

      Conserved Domains (1) summary
      pfam17669
      Location:218293
      DUF5529; Family of unknown function (DUF5529)
    6. XM_036152329.1XP_036008222.1  BTB/POZ domain-containing protein KCTD18 isoform X4

      Conserved Domains (1) summary
      pfam15323
      Location:66174
      Ashwin; Developmental protein

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_030211.3: Suppressed sequence

      Description
      NM_030211.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript appears to retain intronic sequence at its 3' end.