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    Kctd18 potassium channel tetramerisation domain containing 18 [ Mus musculus (house mouse) ]

    Gene ID: 51960, updated on 25-Sep-2017

    Summary

    Official Symbol
    Kctd18provided by MGI
    Official Full Name
    potassium channel tetramerisation domain containing 18provided by MGI
    Primary source
    MGI:MGI:3603813
    See related
    Ensembl:ENSMUSG00000054770 Vega:OTTMUSG00000035129
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4932411A20Rik; 6530404F10Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 4.0), CNS E14 (RPKM 3.8) and 27 other tissues See more
    Orthologs

    Genomic context

    See Kctd18 in Genome Data Viewer
    Location:
    1; 1 C1.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (57955101..57970084, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (58011945..58026928, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene spermine synthase pseudogene Neighboring gene spermatogenesis associated, serine-rich 2-like Neighboring gene shugoshin 2A Neighboring gene aldehyde oxidase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    BTB/POZ domain-containing protein KCTD18

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159864.1NP_001153336.1  BTB/POZ domain-containing protein KCTD18 isoform 1

      See identical proteins and their annotated locations for NP_001153336.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC110735, AK132699, BB678909, BY080515, BY736102
      Consensus CDS
      CCDS48269.1
      UniProtKB/TrEMBL
      E0CZ26
      Related
      ENSMUSP00000110052.3, OTTMUSP00000048864, ENSMUST00000114410.9, OTTMUST00000089405
      Conserved Domains (3) summary
      smart00225
      Location:27109
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam15323
      Location:286394
      Ashwin; Developmental protein
      cl02518
      Location:25109
      BTB; BTB/POZ domain
    2. NM_001159865.1NP_001153337.1  BTB/POZ domain-containing protein KCTD18 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BB678909, BC075692, BY080515, CA530605
      Consensus CDS
      CCDS48268.1
      UniProtKB/TrEMBL
      E9Q945, Q6DI85
      Related
      ENSMUSP00000130952.1, ENSMUST00000164963.7
      Conserved Domains (2) summary
      pfam15323
      Location:119227
      Ashwin; Developmental protein
      cl02518
      Location:2565
      BTB; BTB/POZ domain

    RNA

    1. NR_027630.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' end and at the 3' end of an internal exon compared to variant 1. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD) and is therefore thought to be a noncoding transcript.
      Source sequence(s)
      BB678909, BC075692
      Related
      ENSMUST00000161608.7, OTTMUST00000089406

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      57955101..57970084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496136.3XP_006496199.1  BTB/POZ domain-containing protein KCTD18 isoform X1

      See identical proteins and their annotated locations for XP_006496199.1

      UniProtKB/TrEMBL
      E0CZ26
      Conserved Domains (3) summary
      smart00225
      Location:27109
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam15323
      Location:286394
      Ashwin; Developmental protein
      cl02518
      Location:25109
      BTB; BTB/POZ domain
    2. XM_006496135.2XP_006496198.1  BTB/POZ domain-containing protein KCTD18 isoform X1

      See identical proteins and their annotated locations for XP_006496198.1

      UniProtKB/TrEMBL
      E0CZ26
      Conserved Domains (3) summary
      smart00225
      Location:27109
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam15323
      Location:286394
      Ashwin; Developmental protein
      cl02518
      Location:25109
      BTB; BTB/POZ domain
    3. XM_017321676.1XP_017177165.1  BTB/POZ domain-containing protein KCTD18 isoform X2

    4. XM_017321677.1XP_017177166.1  BTB/POZ domain-containing protein KCTD18 isoform X3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_030211.3: Suppressed sequence

      Description
      NM_030211.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript appears to retain intronic sequence at its 3' end.
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