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    COX7A Cytochrome c oxidase subunit 7A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 50002, updated on 18-Sep-2024

    Summary

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    Official Symbol
    COX7Aprovided by FlyBase
    Official Full Name
    Cytochrome c oxidase subunit 7Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040529
    Locus tag
    Dmel_CG9603
    See related
    AllianceGenome:FB:FBgn0040529
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9603; COX-7A; cox7a; Cox7a; COX7a; COX7A1; COXJ; COXK; Dmel\CG9603; Q9VHS2; VIIa
    Summary
    Predicted to enable cytochrome-c oxidase activity. Predicted to be involved in mitochondrial respirasome assembly and regulation of oxidative phosphorylation. Located in mitochondrion. Is expressed in adult head and adult heart. Used to study cytochrome-c oxidase deficiency disease. Orthologous to several human genes including COX7A1 (cytochrome c oxidase subunit 7A1) and COX7A2 (cytochrome c oxidase subunit 7A2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    Location:
    84F13-84F13; 3-48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8339944..8341043, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4165666..4166765, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Pox meso Neighboring gene Odorant receptor 85a Neighboring gene uncharacterized protein Neighboring gene ADP ribosylation factor-like 2 Neighboring gene Polynucleotide kinase 3'-phosphatase Neighboring gene Cytochrome c oxidase subunit 7A-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Diiron centre mutations in Ciona intestinalis alternative oxidase abolish enzymatic activity and prevent rescue of cytochrome oxidase deficiency in flies. Andjelković A, et al. Sci Rep, 2015 Dec 17. PMID 26672986, Free PMC Article
    2. Effects on Dopaminergic Neurons Are Secondary in COX-Deficient Locomotor Dysfunction in Drosophila. Yalgin C, et al. iScience, 2020 Aug 21. PMID 32738610, Free PMC Article
    3. Mitochondrial electron transport chain defects modify Parkinson's disease phenotypes in a Drosophila model. O'Hanlon ME, et al. Neurobiol Dis, 2022 Sep. PMID 35764292
    4. Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency. Kemppainen KK, et al. Hum Mol Genet, 2014 Apr 15. PMID 24293544, Free PMC Article
    5. Genetic Reduction of Mitochondria Complex I Subunits is Protective against Cisplatin-Induced Neurotoxicity in Drosophila. Groen CM, et al. J Neurosci, 2022 Feb 2. PMID 34893548, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respirasome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of oxidative phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    part_of respiratory chain complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 7A
    Names
    CG9603-PA
    CG9603-PB
    COX7A-PA
    COX7A-PB
    cytochrome c oxidase VIIa
    cytochrome c oxidase polypeptide VIIa

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8339944..8341043 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143927.4 → NP_652184.2  cytochrome c oxidase subunit 7A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652184.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9EQX3, Q9VHS2
      Related
      FBpp0081344
      Conserved Domains (1) summary
      cd00928
      Location:31 → 85
      Cyt_c_Oxidase_VIIa; Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    2. NM_001260057.1 → NP_001246986.1  cytochrome c oxidase subunit 7A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246986.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6C3, D1Z3A3
      Conserved Domains (1) summary
      cd00928
      Location:40 → 94
      Cyt_c_Oxidase_VIIa; Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6C3 A0A0B4K6C3
    Q8SYW9 Q8SYW9
    Q9VHS2.1 Q9VHS2

    Gene LinkOut

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